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Pharmacological and Biochemical Aspects of GABAergic Neurotransmission: Pathological and Neuropsychobiological Relationships

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Abstract

1. The GABAergic neurotransmission has been implicated in the modulation of many neural networks in forebrain, midbrain and hindbrain, as well as, in several neurological disorders.

2. The complete comprehension of GABA system neurochemical properties and the search for approaches in identifying new targets for the treatment of neural diseases related to GABAergic pathway are of the extreme relevance.

3. The present review will be focused on the pharmacology and biochemistry of the GABA metabolism, GABA receptors and transporters. In addition, the pathological and psychobiological implications related to GABAergic neurotransmission will be considered.

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Authors and Affiliations

  1. Departament of Biochemistry and Immunology, School of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil

    Renê Oliveira Beleboni, Ruither Oliveira Gomes Carolino & Joaquim Coutinho-Netto

  2. Departament of Biology, Ribeirão Preto Faculty of Philosophy, Sciences and Literature, University of São Paulo, São Paulo, Brazil

    Andrea Baldocchi Pizzo & Wagner Ferreira dos Santos

  3. Laboratory of Neuroanatomy and Neuropsychobiology, Departament of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil

    Lissandra Castellan-Baldan & Norberto Cysne Coimbra

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  1. Renê Oliveira Beleboni
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  2. Ruither Oliveira Gomes Carolino
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  3. Andrea Baldocchi Pizzo
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  4. Lissandra Castellan-Baldan
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  5. Joaquim Coutinho-Netto
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  6. Wagner Ferreira dos Santos
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  7. Norberto Cysne Coimbra
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Correspondence to Norberto Cysne Coimbra.

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Beleboni, R.O., Carolino, R.O.G., Pizzo, A.B. et al. Pharmacological and Biochemical Aspects of GABAergic Neurotransmission: Pathological and Neuropsychobiological Relationships. Cell Mol Neurobiol 24, 707–728 (2004). https://doi.org/10.1007/s10571-004-6913-z

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