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Cytocompatibility of surface ground PE doped with calcium salt of 6-carboxycellulose

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Abstract

We studied the physical–chemical properties of polyethylene (PE) films doped with calcium salt of 6-carboxycellulose (Ca-oxy) in concentrations 0–20 wt.% and their interactions with cells. The interaction between the PE/Ca-oxy composite film and 3T3 cells has not been described so far. Modification by surface grinding to enhance material cytocompatibility was studied. The surface wettability of doped films was tested by contact angle measurements and the surface morphology by SEM microscopy and profilometry. Adhesion and proliferation of tissue cells (3T3 mouse fibroblasts) were studied in vitro on pristine and ground doped PE films. The ground samples have a higher contact angle values and the number of proliferated cells is greater on the ground samples than on pristine ones. The presence of Ca-oxy in PE film increases the adhesion of 3T3 cells on the doped substrate and on ground samples adhere more cells than on pristine ones.

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Notes

  1. Data provided by Synthesia Pardubice (2007).

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Acknowledgments

The work was supported by the Grant Agency of the Ministry of Industry of the Czech Republic under the projects Nos FT-TA2/013, FT-TA2/011 and 2A-1TP1/041 and Ministry of Education of the CR under Research program No. MSM 6046137302.

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Authors and Affiliations

  1. Department of Solid State Engineering, Institute of Chemical Technology, 166 28, Prague, Czech Republic

    Regina Mikulíková, Václav Švorčík & Josef Náhlík

  2. Aliachem, Synthesia, 532 17, Pardubice, Semtin, Czech Republic

    Tomáš Sopuch

  3. VUOS a.s, 532 18, Pardubice, Rybitvi, Czech Republic

    Pavel Havelka

Authors
  1. Regina Mikulíková
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  2. Václav Švorčík
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  3. Josef Náhlík
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  4. Tomáš Sopuch
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  5. Pavel Havelka
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Correspondence to Václav Švorčík.

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Mikulíková, R., Švorčík, V., Náhlík, J. et al. Cytocompatibility of surface ground PE doped with calcium salt of 6-carboxycellulose. Cellulose 15, 473–479 (2008). https://doi.org/10.1007/s10570-007-9196-y

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  • DOI: https://doi.org/10.1007/s10570-007-9196-y

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