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Gender differential in inclination to donate brain for research among Nigerians: the IBADAN Brain Bank Project

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Abstract

Background

Laboratory-based studies of neurological disease patterns and mechanisms are sparse in sub-Saharan Africa. However, availability of human brain tissue resource depends on willingness towards brain donation. This study evaluated the level of willingness among outpatient clinic attendees in a Nigerian teaching hospital.

Methods

Under the auspices of the IBADAN Brain Bank Project, a 43—item semi-structured interviewer—administered questionnaire was designed to evaluate knowledge, attitude, and beliefs of individuals attending Neurology, Psychiatry and Geriatrics Outpatient clinics regarding willingness to donate brain for research. Association between participants characteristics and willingness towards brain donation was investigated using logistic regression models. Analysis was conducted using Stata SE version 12.0.

Results

A total of 412 participants were interviewed. Their mean age was 46.3 (16.1) years. 229 (55.6%) were females and 92.5% had at least 6 years of formal education. Overall, 109 (26.7%) were willing to donate brains for research. In analyses adjusting for educational status, religion, ethnicity, marital status and family setting, male sex showed independent association with willingness towards brain donation OR (95% CI) 1.7 (1.08–2.69), p = 0.023. Participants suggested public engagement and education through mass media (including social media) and involvement of religious and community leaders as important interventions to improve awareness and willingness towards brain donation.

Conclusion

The survey revealed low willingness among outpatient clinic attendees to donate brain for research, although men were more inclined to donate. It is imperative to institute public engagement and educational interventions in order to improve consent for brain donation for research.

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Acknowledgements

The IBADAN Brain Bank Project is supported by Grant CTR16A012 from the College of Medicine, University of Ibadan, Nigeria while the African Neurobiobank ELSI Project, the SIREN Study and the Systematic Investigation of Blacks with Stroke using Genomics (SIBS Genomics) Study are supported by Grants U01HG010273, U54HG007479 and R01NS107900 respectively from the National Institutes of Health (NIH) as part of the H3Africa Consortium. RA is further supported by an IBRO Return Home Fellowship Grant. RNK acknowledges the support of the Medical Research Council, UK (G1100540) to the Newcastle Brain Tissue Resource (NBTR).

Funding

Funding

This study was funded by Grant CTR16A012 from the College of Medicine, University of Ibadan, Ibadan, Nigeria.

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Authors and Affiliations

  1. Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Nigeria

    Rufus Akinyemi & Mayowa Aridegbe

  2. Department of Psychiatry, College of Medicine, University of Ibadan, Ibadan, Nigeria

    Akin Ojagbemi

  3. Department of Epidemiology and Medical Statistics, College of Medicine, University of Ibadan, Ibadan, Nigeria

    Joshua Akinyemi

  4. Department of Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeria

    Ayodeji Salami & Michael Nweke

  5. Department of Anatomy, College of Medicine, University of Ibadan, Ibadan, Nigeria

    Funmi Olopade

  6. Chief Tony Anenih Geriatric Centre, University College Hospital, Ibadan, Nigeria

    Temitope Farombi

  7. Department of Sociology, Faculty of the Social Sciences, University of Ibadan, Ibadan, Nigeria

    Ayodele Jegede

  8. Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK

    Rajesh Kalaria

  9. Department of Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria

    Ezinne Uvere, Adesola Ogunniyi & Mayowa Owolabi

  10. Department of Surgery, College of Medicine, University of Ibadan, Ibadan, Nigeria

    James Balogun

  11. Department of Radiology, College of Medicine, University of Ibadan, Ibadan, Nigeria

    Godwin Ogbole

  12. Department of Health Promotion and Education, College of Medicine, University of Ibadan, Ibadan, Nigeria

    Oyedunni Arulogun

  13. Neuroscience and Ageing Research Unit, College of Medicine, University of Ibadan, Ibadan, Nigeria

    Rufus Akinyemi

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  1. Rufus Akinyemi
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  2. Akin Ojagbemi
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  3. Joshua Akinyemi
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  4. Ayodeji Salami
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  7. Michael Nweke
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  8. Ezinne Uvere
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  9. Mayowa Aridegbe
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  10. James Balogun
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  11. Godwin Ogbole
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  12. Ayodele Jegede
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  13. Rajesh Kalaria
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  14. Adesola Ogunniyi
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  15. Mayowa Owolabi
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  16. Oyedunni Arulogun
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Corresponding author

Correspondence to Rufus Akinyemi.

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Conflict of interest

All the authors declare no conflict of interest.

Ethical approval

All procedures performed involving human participants in this study were in accordance with the ethical standards of the University of Ibadan/University College Hospital Institutional Review Committee in Ibadan, Nigeria and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Akinyemi, R., Ojagbemi, A., Akinyemi, J. et al. Gender differential in inclination to donate brain for research among Nigerians: the IBADAN Brain Bank Project. Cell Tissue Bank 20, 297–306 (2019). https://doi.org/10.1007/s10561-019-09769-4

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  • DOI: https://doi.org/10.1007/s10561-019-09769-4

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