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Iranian Breast Cancer Bio-Bank: the activity and challenging issues

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Abstract

The information gained from the Human Genome Project has facilitated molecular as well as cellular studies not only to find the origins of Breast Cancer (BC), but also to create novel, and effective treatments. In order to provide an infrastructure for local and international research in this area, Iranian Center for Breast Cancer (ICBC) has established a Bio-Bank (BB) for BC. This article describes the aim, structure, and activities in general, and the challenging issues confronting the bank as a model for the establishment of Bio-Banks in developing countries in particular. The methods employed by the Bank could be explained in the following categories:

  • Blood and Tissue sampling,

  • Preparation and Banking of collected Samples,

  • Clinical and Histopathology data collection,

  • Collaboration Protocol,

  • Challenging issues, and the programs to confront the problems.

During the five-year activity of the bank, 110 families were enrolled for genetic counseling, from whom 600 biologic samples were obtained, including 387 blood samples and 213 tissue samples. Of 387 blood samples, 317 (82%) were found to belong to the BC patients and the remaining 70 (18%) belonged to their available relatives. The number of samples increased over the study period partly as a result of the programs designed to confront the problems. During the study period, there were some finished research studies using the samples of BB, and many other studies which are still ongoing. ICBC-BB is a model of biologic sample banking which provides a significant number of biological samples for local and international collaborative research projects regarding molecular and cellular aspects of BC. In establishing the ICBC-BB we have experienced problems and challenges, some general and some local. Some were expected and others not, but we have identified solutions.

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Abbreviations

BC:

Breast Cancer

FBC:

Familial Breast Cancer

ICBC:

Iranian Center for Breast Cancer

BB:

Biologic Bank

IMMN:

Iranian Molecular Medicine Network

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Acknowledgments

We thank Dr. Masoud Habibi, Dr. Vahid Ghobadi Dana, and Dr. Alireza Bahrami for their continuous supports for ICBC-BB. We also thank all contributing surgeons and operating room staff including Dr. Sadaf Alipour, Dr. Esmat Al Sadat Hashemi, Dr. Masoumeh Najafi, Dr. Mohammadhosein Lashgari, Dr. Nasrinossadat Alavi, Mr. Mohsen Goli, Mrs.Nasrin Abdoli and Mrs. Maryam Ansari for their helping us with tissue sampling. This work was supported partly by Iranian Molecular Medicine Network at Pasteur Institute of Iran (Grant number PM4136) and National Research Center for Medical Sciences at Ministry of Health and Medical Education (Grant number TMM2514).

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Authors and Affiliations

  1. Iranian Center for Breast Cancer (ICBC); Academic Center for Education, Culture and Research (ACECR), No 45, Nazari St, Abureihan St, Enghelab Ave, PO Box: 14155-6615, Tehran, Iran

    Keivan Majidzadeh-A, Rezvan Esmaeili, Leila Farahmand, Mohammad Hossein Shojamoradi, Leila Eini, Fereshteh Abbasvandi, Asieh Olfatbakhsh & Hadi Moazen

  2. AJA University of Medical Sciences, Tehran, Iran

    Keivan Majidzadeh-A

  3. Department of Surgery, Tehran University of Medical Sciences, Tehran, Iran

    Ahmad Kaviani

  4. Young Researchers club, Science and Research Branch, Islamic Azad University, Tehran, Iran

    Ali Akbar Zare

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  1. Keivan Majidzadeh-A
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  2. Ahmad Kaviani
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  3. Rezvan Esmaeili
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  7. Leila Eini
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  9. Asieh Olfatbakhsh
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  10. Hadi Moazen
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Correspondence to Keivan Majidzadeh-A.

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Majidzadeh-A, K., Kaviani, A., Esmaeili, R. et al. Iranian Breast Cancer Bio-Bank: the activity and challenging issues. Cell Tissue Bank 14, 11–20 (2013). https://doi.org/10.1007/s10561-012-9293-5

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  • DOI: https://doi.org/10.1007/s10561-012-9293-5

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