Abstract
The recent introduction as a minimum test required in The Guide to Safety and Quality Assurance for Organs, Tissues and Cells (Council Europe) and the Directive 2004/23/EC applied to donation, procurement, testing, processing, preservation, storage and distribution of human cells and tissues make necessary the implementation of these markers in all European Tissue Establishments. In this study we have analyzed the impact in tissues discard by introducing anti-HBc in a European Tissue Establishment in a country with a high prevalence of HBV infection. The adoption of this exclusion criteria in this region results in acceptably rejection rates among tissue donors, although some studies are needed on basis a risk assessment to determine the eligibility for clinical use.
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Abbreviations
- HBV:
-
Hepatitis B virus
- HCV:
-
Hepatitis C virus
- HIV:
-
Human immunodeficiency virus
- HBs Ag:
-
Hepatitis B surface antigen
- HBc:
-
Hepatitis B core
- NAT:
-
Nucleic acid test
References
Allain JP (2004) Occult hepatitis B virus infection: implications in transfusion. Vox Sanguinis 86:83–91
Allain JP, Reesink HW, Lucey C (2006) A European perspective on the management of donors and units testing positive for hepatitis B virus DNA. Transfusion 46:1256–1258
Alvarez M, Oyonarte S, Rodriguez PM, Hernández JM (2002) Estimated risk of transfusion-transmitted viral infections in Spain. Transfusion 42:994–998
Colomina J, González D, Burgos A, Fernández N, Guerrero A (2005) Significado de la reactividad aislada anti-HBc como único marcador de infección de la hepatitis B. Enf Infecc Microbiol Clin 23:80–85
Kleinman SH, Busch MP (2001). HBV: amplified and back in the blood safety spotlight. Transfusion 41:1081–1085
Kuhns MC, Kleinman SH, McNamara AL, Rawal B, Glynn S, Busch MP (2004) Lack of correlation between HBs Ag and HBV DNA levels in blood donors who test positive for HBsAg and anti-HBc: implications for future HBV screening policy. Transfusion 44:1332–1339
Roth WK, Weber M, Petersen D, Drosten C, Buhr S, Sireis W, Weichert W, Hedges D, Seifried E (2002) NAT for HBV and anti-HBc testing increase blood safety. Transfusion 42:869–875
Strong DM, Nelson K, Pierce M, Stramer SL (2005) Preventing disease transmission by deceased tissue donors by testing blood for viral nucleic acid. Cell Tissue Bank 6:255–262
Zervou EK, Dalekos GN, Boumba DS, Tsianos EV (2001) Value of anti-HBc screening of blood donors for prevention of HBV infection: results of a 3-year prospective study in nortwestern Greece. Transfusion 41:652–658
Zou S, Dodd RY, Stramer SL, Strong DM (2004) Probability of viremia with HBV, HCV, HIV, and HTLV among tissue donors in the United States. N Engl J Med 351:751–759
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Villalba, R., Fornés, G., Eisman, M. et al. Evaluation of tissue discards after implementation of anti-HBc test in a tissue bank in Spain. Cell Tissue Banking 8, 303–305 (2007). https://doi.org/10.1007/s10561-007-9039-y
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DOI: https://doi.org/10.1007/s10561-007-9039-y