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Physics of Open Systems: Effects of the Impact of Chemical Stressors on Differential Gene Expression

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Cybernetics and Systems Analysis Aims and scope

Abstract

The technologies of the physics of open systems are applied to generate the systemic knowledge about variations in gene activity under the impact of chemical stressors. The system knowledge is automatically generated based on the genomic data obtained by using the microarray technology. The system knowledge has been used for scientific understanding and rational explanation of regular changes in gene activity depending on the biomaterial sample, type of the chemical and its concentration, and time series of experiments.

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Authors and Affiliations

  1. St. Petersburg Electrotechnical University “LETI”, St. Petersburg, Russia

    V. O. Ageev, T. L. Kachanova, B. F. Fomin & O. B. Fomin

  2. United States Environmental Protection Agency, Washington, USA

    L. Kopylev, M. Spassova & Chen W. Chao

Authors
  1. V. O. Ageev
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  2. T. L. Kachanova
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  3. L. Kopylev
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  4. M. Spassova
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  5. B. F. Fomin
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  6. O. B. Fomin
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  7. Chen W. Chao
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Corresponding authors

Correspondence to B. F. Fomin or O. B. Fomin.

Additional information

The paper is prepared with support of grant ISTC № 3476p (2006–2011) “Unified Method of State Space Modeling of Biological Systems”.

Translated from Kibernetika i Sistemnyi Analiz, No. 2, March–April, 2014, pp. 64–74.

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Ageev, V.O., Kachanova, T.L., Kopylev, L. et al. Physics of Open Systems: Effects of the Impact of Chemical Stressors on Differential Gene Expression. Cybern Syst Anal 50, 218–227 (2014). https://doi.org/10.1007/s10559-014-9608-6

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  • DOI: https://doi.org/10.1007/s10559-014-9608-6

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