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Genetics of Triglyceride-Rich Lipoproteins Guide Identification of Pharmacotherapy for Cardiovascular Risk Reduction

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Abstract

Objective: Despite aggressive reduction of low-density lipoprotein cholesterol (LDL-C), there is a residual risk of cardiovascular disease (CVD). Hypertriglyceridemia is known to be associated with increased CVD risk, independently of LDL-C. Triglycerides are one component of the heterogenous class of triglyceride-rich lipoproteins (TGRLs). Methods/Results: Growing evidence from biology, epidemiology, and genetics supports the contribution of TGRLs to the development of CVD via a number of mechanisms, including through proinflammatory, proapoptotic, and procoagulant pathways. Conclusion: New genetics-guided pharmacotherapies to reduce levels of triglycerides and TGRLs and thus reduce risk of CVD have been developed and will be discussed here.

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Authors and Affiliations

  1. Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Aleesha Shaik

  2. Cardiometabolics Unit, Zena and Michael A Wiener Cardiovascular Institute, Marie-Josee and Henry R Kravis Center for Cardiovascular Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Robert S. Rosenson

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Dr. Rosenson reports research funding to the institution from Amgen, Astra Zeneca Medicines Company, National Institutes of Health, Novartis, Regeneron, consulting fees from Amgen, Medicines Company, Novartis, Regeneron and 89 Bio, honoraria for non-promotional speaking fees from Amgen, Kowa and Regeneron, royalties from Wolters Kluwer (UpToDate) and stock holdings in MediMergent, LLC.

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Shaik, A., Rosenson, R.S. Genetics of Triglyceride-Rich Lipoproteins Guide Identification of Pharmacotherapy for Cardiovascular Risk Reduction. Cardiovasc Drugs Ther 35, 677–690 (2021). https://doi.org/10.1007/s10557-021-07168-0

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