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The Mitochondrial Permeability Transition Pore as a Target for Cardioprotection in Hypertrophic Cardiomyopathy

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References

  1. Maron MS, Olivotto I, Maron BJ, et al. The case for myocardial ischemia in hypertrophic cardiomyopathy. J Am Coll Cardiol. 2009;54(9):866–75.

    Article  PubMed  Google Scholar 

  2. Hausenloy DJ, Yellon DM. The mitochondrial permeability transition pore: its fundamental role in mediating cell death during ischaemia and reperfusion. J Mol Cell Cardiol. 2003;35(4):339–41.

    Article  PubMed  CAS  Google Scholar 

  3. Leung AW, Halestrap AP. Recent progress in elucidating the molecular mechanism of the mitochondrial permeability transition pore. Biochim Biophys Acta. 2008;1777(7–8):946–52.

    PubMed  CAS  Google Scholar 

  4. Hausenloy DJ, Duchen MR, Yellon DM. Inhibiting mitochondrial permeability transition pore opening at reperfusion protects against ischaemia-reperfusion injury. Cardiovasc Res. 2003;60(3):617–25.

    Article  PubMed  CAS  Google Scholar 

  5. Shanmuganathan S, Hausenloy DJ, Duchen MR, Yellon DM. Mitochondrial permeability transition pore as a target for cardioprotection in the human heart. Am J Physiol Heart Circ Physiol. 2005;289(1):H237–42.

    Article  PubMed  CAS  Google Scholar 

  6. Piot C, Croisille P, Staat P, et al. Effect of cyclosporine on reperfusion injury in acute myocardial infarction. N Engl J Med. 2008;359(5):473–81.

    Article  PubMed  CAS  Google Scholar 

  7. Argaud L, Gateau-Roesch O, Muntean D, et al. Specific inhibition of the mitochondrial permeability transition prevents lethal reperfusion injury. J Mol Cell Cardiol. 2005;38(2):367–74.

    Article  PubMed  CAS  Google Scholar 

  8. Ludman A, Venugopal V, Yellon DM, Hausenloy DJ. Statins and cardioprotection–more than just lipid lowering? Pharmacol Ther. 2009;122(1):30–43.

    Article  PubMed  CAS  Google Scholar 

  9. Atar S, Ye Y, Lin Y, et al. Atorvastatin-induced cardioprotection is mediated by increasing inducible nitric oxide synthase and consequent S-nitrosylation of cyclooxygenase-2. Am J Physiol Heart Circ Physiol. 2006;290(5):H1960–8.

    Article  PubMed  CAS  Google Scholar 

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Acknowledgments

The authors are grateful for the support of the British Heart Foundation (grant number FS/06/023). This study was carried out at the Heart Hospital/University College London Hospital and University College London, which received a proportion of funding from the Department of Health’s NIHR Biomedical Research Centres funding scheme.

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Authors and Affiliations

  1. The Hatter Cardiovascular Institute, University College London, 67 Chenies Mews, London, WC1E 6HX, UK

    P. S. C. Rees, S. M. Davidson, D. M. Yellon & D. J. Hausenloy

  2. The National Heart and Lung Institute, Imperial College London, London, UK

    S. E. Harding

  3. The Heart Hospital, University College London Hospitals, London, UK

    C. McGregor & P. M. Elliot

  4. The London Chest Hospital, Barts Health NHS Trust & Defence Medical Services, London, UK

    P. S. C. Rees

Authors
  1. P. S. C. Rees
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  2. S. M. Davidson
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  3. S. E. Harding
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  4. C. McGregor
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  5. P. M. Elliot
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  6. D. M. Yellon
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  7. D. J. Hausenloy
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Corresponding author

Correspondence to D. J. Hausenloy.

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Rees, P.S.C., Davidson, S.M., Harding, S.E. et al. The Mitochondrial Permeability Transition Pore as a Target for Cardioprotection in Hypertrophic Cardiomyopathy. Cardiovasc Drugs Ther 27, 235–237 (2013). https://doi.org/10.1007/s10557-013-6447-z

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  • DOI: https://doi.org/10.1007/s10557-013-6447-z

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