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Molecular Mechanisms of Cross-talk between Thyroid Hormone and Peroxisome Proliferator Activated Receptors: Focus on the Heart

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Abstract

Thyroid hormone receptors (TR) and peroxisome proliferator activated receptors (PPAR) regulate cardiac metabolism. Numerous studies have examined TR and PPAR function since PPAR was first discovered in the early 1990s, however few have evaluated TR and PPAR interactions. Although ligands for these members of the nuclear steroid receptor family are under evaluation for treatment of congestive heart failure and various metabolic diseases, their interactions have not been investigated in detail in heart. These interactions are remarkably complicated. Nevertheless, their identification and elucidation is extremely important for further development of specific drugs. We review here the fundamental ways TRs and PPARs are regulated and how their cross-talk patterns mediate transcription of their target genes.

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Authors and Affiliations

  1. Division of Cardiology, Department of Pediatrics, Children’s Hospital & Regional Medical Center, 4800 Sandpoint Way NE, 4G-1, Seattle, WA, 98105, USA

    Outi M. Hyyti & Michael A. Portman

  2. Department of Pediatrics, University of Washington, 1959 NE Pacific St., Seattle, WA, 98105, USA

    Outi M. Hyyti & Michael A. Portman

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  1. Outi M. Hyyti
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Correspondence to Michael A. Portman.

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Hyyti, O.M., Portman, M.A. Molecular Mechanisms of Cross-talk between Thyroid Hormone and Peroxisome Proliferator Activated Receptors: Focus on the Heart. Cardiovasc Drugs Ther 20, 463–469 (2006). https://doi.org/10.1007/s10557-006-0643-z

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