Abstract
Hematopoietic stem cell transplantation (HSCT) is used in children to treat a variety of malignant and nonmalignant hematologic conditions and certain inborn errors of metabolism. Survivors of HSCT are markedly affected by disease and treatment toxicity. Endocrine complications are among the most commonly reported chronic health conditions in this population. In this review, we summarize the most common endocrine late effects after pediatric HSCT. We also highlight the importance of systematic and longitudinal evaluations to achieve early diagnoses and treatment for these conditions and improve the long-term health outcomes for patients who received HSCT as children.
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Gyurkocza, B., & Sandmaier, B. M. (2014). Conditioning regimens for hematopoietic cell transplantation: One size does not fit all. Blood, 124(3), 344–353. https://doi.org/10.1182/blood-2014-02-514778.
Ruutu, T., Gratwohl, A., de Witte, T., Afanasyev, B., Apperley, J., Bacigalupo, A., Dazzi, F., Dreger, P., Duarte, R., Finke, J., Garderet, L., Greinix, H., Holler, E., Kröger, N., Lawitschka, A., Mohty, M., Nagler, A., Passweg, J., Ringdén, O., Socié, G., Sierra, J., Sureda, A., Wiktor-Jedrzejczak, W., Madrigal, A., & Niederwieser, D. (2014). Prophylaxis and treatment of GVHD: EBMT-ELN working group recommendations for a standardized practice. Bone Marrow Transplantation, 49(2), 168–173. https://doi.org/10.1038/bmt.2013.107.
Eissa, H. M., Lu, L., Baassiri, M., Bhakta, N., Ehrhardt, M. J., Triplett, B. M., Green, D. M., Mulrooney, D. A., Robison, L. L., Hudson, M. M., & Ness, K. K. (2017). Chronic disease burden and frailty in survivors of childhood HSCT: A report from the St. Jude lifetime cohort study. Blood Adv, 1(24), 2243–2246. https://doi.org/10.1182/bloodadvances.2017010280.
Armenian, S. H., Sun, C. L., Kawashima, T., Arora, M., Leisenring, W., Sklar, C. A., Baker, K. S., Francisco, L., Teh, J. B., Mills, G., Wong, F. L., Rosenthal, J., Diller, L. R., Hudson, M. M., Oeffinger, K. C., Forman, S. J., Robison, L. L., & Bhatia, S. (2011). Long-term health-related outcomes in survivors of childhood cancer treated with HSCT versus conventional therapy: A report from the bone marrow transplant survivor study (BMTSS) and childhood Cancer survivor study (CCSS). Blood, 118(5), 1413–1420. https://doi.org/10.1182/blood-2011-01-331835.
Hows, J. M., Passweg, J. R., Tichelli, A., Locasciulli, A., Szydlo, R., Bacigalupo, A., et al. (2006). Comparison of long-term outcomes after allogeneic hematopoietic stem cell transplantation from matched sibling and unrelated donors. Bone Marrow Transplant, 38(12), 799–805. https://doi.org/10.1038/sj.bmt.1705531.
Leung, W., Ahn, H., Rose, S. R., Phipps, S., Smith, T., Gan, K., et al. (2007). A prospective cohort study of late sequelae of pediatric allogeneic hematopoietic stem cell transplantation. Medicine (Baltimore), 86(4), 215–224. https://doi.org/10.1097/MD.0b013e31812f864d.
Baker, K. S., Ness, K. K., Weisdorf, D., Francisco, L., Sun, C. L., Forman, S., et al. (2010, Leukemia). Late effects in survivors of acute leukemia treated with hematopoietic cell transplantation: A report from the bone marrow transplant survivor study., 24(12), 2039–2047. https://doi.org/10.1038/leu.2010.210.
Thomas, B. C., Stanhope, R., Plowman, P. N., & Leiper, A. D. (1993). Endocrine function following single fraction and fractionated total body irradiation for bone marrow transplantation in childhood. Acta Endocrinol.(Copenh), 128(6), 508–512.
Chemaitilly, W., Boulad, F., Heller, G., Kernan, N. A., Small, T. N., O'Reilly, R. J., et al. (2007). Final height in pediatric patients after hyperfractionated total body irradiation and stem cell transplantation. Bone Marrow Transplant, 40(1), 29–35. https://doi.org/10.1038/sj.bmt.1705694.
Barfield, R. C., Kasow, K. A., & Hale, G. A. (2008). Advances in pediatric hematopoietic stem cell transplantation. Cancer Biology & Therapy, 7(10), 1533–1539.
Baird, K., Cooke, K., & Schultz, K. R. (2010). Chronic graft-versus-host disease (GVHD) in children. Pediatric Clinics of North America, 57(1), 297–322. https://doi.org/10.1016/j.pcl.2009.11.003.
Shalitin, S., Phillip, M., Stein, J., Goshen, Y., Carmi, D., & Yaniv, I. (2006). Endocrine dysfunction and parameters of the metabolic syndrome after bone marrow transplantation during childhood and adolescence. Bone Marrow Transplant, 37(12), 1109–1117. https://doi.org/10.1038/sj.bmt.1705374.
Vantyghem, M. C., Cornillon, J., Decanter, C., Defrance, F., Karrouz, W., Leroy, C., le Mapihan, K., Couturier, M. A., de Berranger, E., Hermet, E., Maillard, N., Marcais, A., Francois, S., Tabrizi, R., Yakoub-Agha, I., & Société Française de Thérapie Cellulaire. (2014). Management of endocrino-metabolic dysfunctions after allogeneic hematopoietic stem cell transplantation. Orphanet Journal of Rare Diseases, 9, 162. https://doi.org/10.1186/s13023-014-0162-0.
Chemaitilly, W., & Sklar, C. A. (2007). Endocrine complications of hematopoietic stem cell transplantation. Endocrinol.Metab Clin.North Am., 36(4), 983–998. https://doi.org/10.1016/j.ecl.2007.07.002.
Dvorak, C. C., Gracia, C. R., Sanders, J. E., Cheng, E. Y., Baker, K. S., Pulsipher, M. A., et al. (2011). NCI, NHLBI/PBMTC first international conference on late effects after pediatric hematopoietic cell transplantation: Endocrine challenges-thyroid dysfunction, growth impairment, bone health, & reproductive risks. Biol.Blood Marrow Transplant., 17(12), 1725–1738. https://doi.org/10.1016/j.bbmt.2011.10.006.
Cohen, A., Bekassy, A. N., Gaiero, A., Faraci, M., Zecca, S., Tichelli, A., et al. (2008). Endocrinological late complications after hematopoietic SCT in children. Bone Marrow Transplant, 41(Suppl 2), S43–S48. https://doi.org/10.1038/bmt.2008.54.
Clement-de, B. A., Oostdijk, W., Van Weel-Sipman, M. H., Van den Broeck, J., Wit, J. M., & Vossen, J. M. (1996). Final height and hormonal function after bone marrow transplantation in children. J.Pediatr., 129(4), 544–550.
Sanders, J. E., Guthrie, K. A., Hoffmeister, P. A., Woolfrey, A. E., Carpenter, P. A., & Appelbaum, F. R. (2005). Final adult height of patients who received hematopoietic cell transplantation in childhood. Blood, 105(3), 1348–1354. https://doi.org/10.1182/blood-2004-07-2528.
Brauner, R., Fontoura, M., Zucker, J. M., Devergie, A., Souberbielle, J. C., Prevot-Saucet, C., Michon, J., Gluckman, E., Griscelli, C., & Fischer, A. (1993). Growth and growth hormone secretion after bone marrow transplantation. Arch.Dis.Child, 68(4), 458–463.
Rose, S. R., Lustig, R. H., Pitukcheewanont, P., Broome, D. C., Burghen, G. A., Li, H., et al. (1999). Diagnosis of hidden central hypothyroidism in survivors of childhood cancer. J.Clin.Endocrinol.Metab, 84(12), 4472–4479. https://doi.org/10.1210/jcem.84.12.6097.
Sanders, J. E., Pritchard, S., Mahoney, P., Amos, D., Buckner, C. D., Witherspoon, R. P., Deeg, H. J., Doney, K. C., Sullivan, K. M., & Appelbaum, F. R. (1986). Growth and development following marrow transplantation for leukemia. Blood, 68(5), 1129–1135.
Ogilvy-Stuart, A. L., Clark, D. J., Wallace, W. H., Gibson, B. E., Stevens, R. F., Shalet, S. M., & Donaldson, M. D. (1992). Endocrine deficit after fractionated total body irradiation. Arch.Dis.Child, 67(9), 1107–1110.
Michel, G., Socie, G., Gebhard, F., Bernaudin, F., Thuret, I., Vannier, J. P., et al. (1997). Late effects of allogeneic bone marrow transplantation for children with acute myeloblastic leukemia in first complete remission: The impact of conditioning regimen without total-body irradiation--a report from the Societe Francaise de Greffe de Moelle. J.Clin.Oncol., 15(6), 2238–2246.
Berger, C., Le-Gallo, B., Donadieu, J., Richard, O., Devergie, A., Galambrun, C., et al. (2005). Late thyroid toxicity in 153 long-term survivors of allogeneic bone marrow transplantation for acute lymphoblastic leukaemia. Bone Marrow Transplant, 35(10), 991–995. https://doi.org/10.1038/sj.bmt.1704945.
Sklar, C. A., Kim, T. H., & Ramsay, N. K. (1982). Thyroid dysfunction among long-term survivors of bone marrow transplantation. Am.J.Med., 73(5), 688–694. https://doi.org/10.1016/0002-9343(82)90411-9.
Boulad, F., Bromley, M., Black, P., Heller, G., Sarafoglou, K., Gillio, A., et al. (1995). Thyroid dysfunction following bone marrow transplantation using hyperfractionated radiation. Bone Marrow Transplantation, 15(1), 71–76.
Sklar, C., Boulad, F., Small, T., & Kernan, N. (2001). Endocrine complications of pediatric stem cell transplantation. Frontiers in Bioscience, 6, G17–G22.
Cohen, A., Rovelli, A., Merlo, D. F., van Lint, M. T., Lanino, E., Bresters, D., et al. (2007). Risk for secondary thyroid carcinoma after hematopoietic stem-cell transplantation: An EBMT late effects working party study. J.Clin.Oncol., 25(17), 2449–2454. https://doi.org/10.1200/JCO.2006.08.9276.
Afify, Z., Shaw, P. J., Clavano-Harding, A., & Cowell, C. T. (2000). Growth and endocrine function in children with acute myeloid leukaemia after bone marrow transplantation using busulfan/cyclophosphamide. Bone Marrow Transplant., 25(10), 1087–1092. https://doi.org/10.1038/sj.bmt.1702384.
Sarafoglou, K., Boulad, F., Gillio, A., & Sklar, C. (1997). Gonadal function after bone marrow transplantation for acute leukemia during childhood. J. Pediatr., 130(2), 210–216. https://doi.org/10.1016/s0022-3476(97)70345-7.
Matsumoto, M., Shinohara, O., Ishiguro, H., Shimizu, T., Hattori, K., Ichikawa, M., et al. (1999). Ovarian function after bone marrow transplantation performed before menarche. Arch. Dis. Child, 80(5), 452–454.
Sanders, J. E., Buckner, C. D., Amos, D., Levy, W., Appelbaum, F. R., Doney, K., Storb, R., Sullivan, K. M., Witherspoon, R. P., & Thomas, E. D. (1988). Ovarian function following marrow transplantation for aplastic anemia or leukemia. J.Clin.Oncol., 6(5), 813–818.
Anderson, R. A., Mitchell, R. T., Kelsey, T. W., Spears, N., Telfer, E. E., & Wallace, W. H. (2015). Cancer treatment and gonadal function: Experimental and established strategies for fertility preservation in children and young adults. Lancet Diabetes Endocrinol, 3(7), 556–567. https://doi.org/10.1016/S2213-8587(15)00039-X.
Nakagawa, K., Kanda, Y., Yamashita, H., Nakagawa, S., Sasano, N., Ohtomo, K., et al. (2008). Ovarian shielding allows ovarian recovery and normal birth in female hematopoietic SCT recipients undergoing TBI. Bone Marrow Transplant, 42(10), 697–699. https://doi.org/10.1038/bmt.2008.234.
Assouline, E., Crocchiolo, R., Prebet, T., Broussais, F., Coso, D., Gamerre, M., et al. (2013). Impact of reduced-intensity conditioning allogeneic stem cell transplantation on women's fertility. Clinical Lymphoma, Myeloma & Leukemia, 13(6), 704–710. https://doi.org/10.1016/j.clml.2013.05.014.
Sanders, J. E., Hawley, J., Levy, W., Gooley, T., Buckner, C. D., Deeg, H. J., Doney, K., Storb, R., Sullivan, K., Witherspoon, R., & Appelbaum, F. R. (1996). Pregnancies following high-dose cyclophosphamide with or without high-dose busulfan or total-body irradiation and bone marrow transplantation. Blood, 87(7), 3045–3052.
Bath, L. E., Critchley, H. O., Chambers, S. E., Anderson, R. A., Kelnar, C. J., & Wallace, W. H. (1999). Ovarian and uterine characteristics after total body irradiation in childhood and adolescence: Response to sex steroid replacement. Br.J.Obstet.Gynaecol., 106(12), 1265–1272.
Anserini, P., Chiodi, S., Spinelli, S., Costa, M., Conte, N., Copello, F., et al. (2002). Semen analysis following allogeneic bone marrow transplantation. Additional data for evidence-based counselling. Bone Marrow Transplant, 30(7), 447–451. https://doi.org/10.1038/sj.bmt.1703651.
Rovo, A., Tichelli, A., Passweg, J. R., Heim, D., Meyer-Monard, S., Holzgreve, W., et al. (2006). Spermatogenesis in long-term survivors after allogeneic hematopoietic stem cell transplantation is associated with age, time interval since transplantation, and apparently absence of chronic GvHD. Blood, 108(3), 1100–1105. https://doi.org/10.1182/blood-2006-01-0176.
Ishiguro, H., Yasuda, Y., Tomita, Y., Shinagawa, T., Shimizu, T., Morimoto, T., et al. (2007). Gonadal shielding to irradiation is effective in protecting testicular growth and function in long-term survivors of bone marrow transplantation during childhood or adolescence. Bone Marrow Transplant, 39(8), 483–490. https://doi.org/10.1038/sj.bmt.1705612.
Sklar, C. A., Robison, L. L., Nesbit, M. E., Sather, H. N., Meadows, A. T., Ortega, J. A., et al. (1990). Effects of radiation on testicular function in long-term survivors of childhood acute lymphoblastic leukemia: A report from the children Cancer study group. J.Clin.Oncol., 8(12), 1981–1987.
Kaste, S. C., Shidler, T. J., Tong, X., Srivastava, D. K., Rochester, R., Hudson, M. M., et al. (2004). Bone mineral density and osteonecrosis in survivors of childhood allogeneic bone marrow transplantation. Bone Marrow Transplant, 10.1038/sj.bmt.1704360, 33(4), 435–441.
Mostoufi-Moab, S., & Ward, L. M. (2018). Skeletal morbidity in children and adolescents during and following Cancer therapy. Hormone Research in Pædiatrics, 1–15. https://doi.org/10.1159/000494809.
Mostoufi-Moab, S., Magland, J., Isaacoff, E. J., Sun, W., Rajapakse, C. S., Zemel, B., et al. (2015). Adverse fat depots and marrow adiposity are associated with skeletal deficits and insulin resistance in long-term survivors of pediatric hematopoietic stem cell transplantation. J.Bone Miner.Res., 30(9), 1657–1666. https://doi.org/10.1002/jbmr.2512.
Taskinen, M., Saarinen-Pihkala, U. M., Hovi, L., & Lipsanen-Nyman, M. (2000). Impaired glucose tolerance and dyslipidaemia as late effects after bone-marrow transplantation in childhood. Lancet, 356(9234), 993–997. https://doi.org/10.1016/S0140-6736(00)02717-3.
Hoffmeister, P. A., Storer, B. E., & Sanders, J. E. (2004). Diabetes mellitus in long-term survivors of pediatric hematopoietic cell transplantation. J.Pediatr.Hematol.Oncol., 26(2), 81–90. https://doi.org/10.1097/00043426-200402000-00003.
Traggiai, C., Stanhope, R., Nussey, S., & Leiper, A. D. (2003). Diabetes mellitus after bone marrow transplantation during childhood. Med.Pediatr.Oncol., 40(2), 128–129. https://doi.org/10.1002/mpo.10098.
Chemaitilly, W., Boulad, F., Oeffinger, K. C., & Sklar, C. A. (2009). Disorders of glucose homeostasis in young adults treated with total body irradiation during childhood: A pilot study. Bone Marrow Transplant, 44(6), 339–343. https://doi.org/10.1038/bmt.2009.40.
Montero, N., & Pascual, J. (2015). Immunosuppression and post-transplant hyperglycemia. Current Diabetes Reviews, 11(3), 144–154.
Chow, E. J., Liu, W., Srivastava, K., Leisenring, W. M., Hayashi, R. J., Sklar, C. A., et al. (2013). Differential effects of radiotherapy on growth and endocrine function among acute leukemia survivors: A childhood cancer survivor study report. Pediatr.Blood Cancer, 60(1), 110–115. https://doi.org/10.1002/pbc.24198.
Neville, K. A., Cohn, R. J., Steinbeck, K. S., Johnston, K., & Walker, J. L. (2006). Hyperinsulinemia, impaired glucose tolerance, and diabetes mellitus in survivors of childhood cancer: Prevalence and risk factors. J.Clin.Endocrinol.Metab, 91(11), 4401–4407. https://doi.org/10.1210/jc.2006-0128.
Meacham, L. R., Sklar, C. A., Li, S., Liu, Q., Gimpel, N., Yasui, Y., et al. (2009). Diabetes mellitus in long-term survivors of childhood cancer. Increased risk associated with radiation therapy: A report for the childhood cancer survivor study. Arch.Intern.Med., 169(15), 1381–1388. https://doi.org/10.1001/archinternmed.2009.209.
Wei, C., Thyagiarajan, M. S., Hunt, L. P., Shield, J. P., Stevens, M. C., & Crowne, E. C. (2015). Reduced insulin sensitivity in childhood survivors of haematopoietic stem cell transplantation is associated with lipodystropic and sarcopenic phenotypes. Pediatr.Blood Cancer, 62(11), 1992–1999. https://doi.org/10.1002/pbc.25601.
Wei, C., Thyagiarajan, M., Hunt, L., Cox, R., Bradley, K., Elson, R., et al. (2015). Reduced beta-cell reserve and pancreatic volume in survivors of childhood acute lymphoblastic leukaemia treated with bone marrow transplantation and total body irradiation. Clin.Endocrinol.(Oxf), 82(1), 59–67. https://doi.org/10.1111/cen.12575.
de Vathaire, F., El-Fayech, C., Ben Ayed, F. F., Haddy, N., Guibout, C., Winter, D., et al. (2012). Radiation dose to the pancreas and risk of diabetes mellitus in childhood cancer survivors: A retrospective cohort study. The Lancet Oncology, 13(10), 1002–1010. https://doi.org/10.1016/S1470-2045(12)70323-6.
Oudin, C., Simeoni, M. C., Sirvent, N., Contet, A., Begu-Le, C. A., Bordigoni, P., et al. (2011). Prevalence and risk factors of the metabolic syndrome in adult survivors of childhood leukemia. Blood, 117(17), 4442–4448. https://doi.org/10.1182/blood-2010-09-304899.
Paris, C., Yates, L., Lama, P., Zepeda, A. J., Gutierrez, D., & Palma, J. (2012). Evaluation of metabolic syndrome after hematopoietic stem cell transplantation in children and adolescents. Pediatric Blood & Cancer, 59(2), 306–310. https://doi.org/10.1002/pbc.24104.
Armenian, S. H., Chemaitilly, W., Chen, M., Chow, E. J., Duncan, C. N., Jones, L. W., et al. (2016). National Institutes of Health hematopoietic cell transplantation late effects Initiative: The Cardiovascular Disease and Associated Risk Factors Working Group Report. Biol Blood Marrow Transplant, 23, 201. https://doi.org/10.1016/j.bbmt.2016.08.019.
Turcotte, L. M., Yingst, A., & Verneris, M. R. (2016). Metabolic syndrome after hematopoietic cell transplantation: At the intersection of treatment toxicity and immune dysfunction. Biology of Blood and Marrow Transplantation, 22(7), 1159–1166. https://doi.org/10.1016/j.bbmt.2016.03.016.
Ness, K. K., Krull, K. R., Jones, K. E., Mulrooney, D. A., Armstrong, G. T., Green, D. M., et al. (2013). Physiologic frailty as a sign of accelerated aging among adult survivors of childhood cancer: A report from the St Jude lifetime cohort study. J.Clin.Oncol., 31(36), 4496–4503. https://doi.org/10.1200/JCO.2013.52.2268.
Chow, E. J., Anderson, L., Baker, K. S., Bhatia, S., Guilcher, G. M., Huang, J. T., Pelletier, W., Perkins, J. L., Rivard, L. S., Schechter, T., Shah, A. J., Wilson, K. D., Wong, K., Grewal, S. S., Armenian, S. H., Meacham, L. R., Mulrooney, D. A., & Castellino, S. M. (2016). Late effects surveillance recommendations among survivors of childhood hematopoietic cell transplantation: A Children's oncology group report. Biology of Blood and Marrow Transplantation, 22(5), 782–795. https://doi.org/10.1016/j.bbmt.2016.01.023.
Kremer, L. C., Mulder, R. L., Oeffinger, K. C., Bhatia, S., Landier, W., Levitt, G., et al. (2013). A worldwide collaboration to harmonize guidelines for the long-term follow-up of childhood and young adult cancer survivors: A report from the international late effects of childhood Cancer guideline harmonization group. Pediatr.Blood Cancer, 60(4), 543–549. https://doi.org/10.1002/pbc.24445.
Sklar, C. A., Antal, Z., Chemaitilly, W., Cohen, L. E., Follin, C., Meacham, L. R., et al. (2018). Hypothalamic-pituitary and growth disorders in survivors of childhood Cancer: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab, 103, 2761. https://doi.org/10.1210/jc.2018-01175.
Sfeir, J. G., Kittah, N. E., Tamhane, S. U., Jasim, S., Chemaitilly, W., Cohen, L., et al. (2018). Diagnosis of growth hormone deficiency as a late effect of radiotherapy in survivors of childhood cancers. The Journal of Clinical Endocrinology and Metabolism. https://doi.org/10.1210/jc.2018-01204.
Tamhane, S., Sfeir, J. G., Kittah, N. E. N., Jasim, S., Chemaitilly, W., Cohen, L. E., et al. (2018). Growth hormone therapy in childhood Cancer Survivors: A Systematic Review and Meta-analysis. J Clin Endocrinol Metab. https://doi.org/10.1210/jc.2018-01205.
Raman, S., Grimberg, A., Waguespack, S. G., Miller, B. S., Sklar, C. A., Meacham, L. R., et al. (2015). Risk of Neoplasia in pediatric patients receiving growth hormone therapy - a report from the pediatric Endocrine Society drug and therapeutics committee. J.Clin.Endocrinol.Metab. https://doi.org/10.1210/jc.2015-1002.
Leschek, E. W., Rose, S. R., Yanovski, J. A., Troendle, J. F., Quigley, C. A., Chipman, J. J., et al. (2004). Effect of growth hormone treatment on adult height in peripubertal children with idiopathic short stature: A randomized, double-blind, placebo-controlled trial. The Journal of Clinical Endocrinology and Metabolism, 89(7), 3140–3148. https://doi.org/10.1210/jc.2003-031457.
Mauras, N., Ross, J. L., Gagliardi, P., Yu, Y. M., Hossain, J., Permuy, J., Damaso, L., Merinbaum, D., Singh, R. J., Gaete, X., & Mericq, V. (2016). Randomized trial of aromatase inhibitors, growth hormone, or combination in pubertal boys with idiopathic, short stature. The Journal of Clinical Endocrinology and Metabolism, 101(12), 4984–4993. https://doi.org/10.1210/jc.2016-2891.
Chemaitilly, W., Cohen, L. E., Mostoufi-Moab, S., Patterson, B. C., Simmons, J. H., Meacham, L. R., van Santen, H., & Sklar, C. A. (2018). Endocrine late effects in childhood Cancer survivors. Journal of Clinical Oncology, 36(21), 2153–2159. https://doi.org/10.1200/JCO.2017.76.3268.
Clement, S. C., Kremer, L. C. M., Verburg, F. A., Simmons, J. H., Goldfarb, M., Peeters, R. P., Alexander, E. K., Bardi, E., Brignardello, E., Constine, L. S., Dinauer, C. A., Drozd, V. M., Felicetti, F., Frey, E., Heinzel, A., van den Heuvel-Eibrink, M., Huang, S. A., Links, T. P., Lorenz, K., Mulder, R. L., Neggers, S. J., Nieveen van Dijkum, E., Oeffinger, K. C., van Rijn, R., Rivkees, S. A., Ronckers, C. M., Schneider, A. B., Skinner, R., Wasserman, J. D., Wynn, T., Hudson, M. M., Nathan, P. C., & van Santen, H. (2018). Balancing the benefits and harms of thyroid cancer surveillance in survivors of childhood, adolescent and young adult cancer: Recommendations from the international late effects of childhood Cancer guideline harmonization group in collaboration with the PanCareSurFup consortium. Cancer Treatment Reviews, 63, 28–39. https://doi.org/10.1016/j.ctrv.2017.11.005.
Francis, G. L., Waguespack, S. G., Bauer, A. J., Angelos, P., Benvenga, S., Cerutti, J. M., et al. (2015). Management guidelines for children with thyroid nodules and differentiated thyroid Cancer. Thyroid, 25(7), 716–759. https://doi.org/10.1089/thy.2014.0460.
Cooper, D. S., Doherty, G. M., Haugen, B. R., Kloos, R. T., Lee, S. L., Mandel, S. J., et al. (2009). Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid, 19(11), 1167–1214. https://doi.org/10.1089/thy.2009.0110.
Bhasin, S., Brito, J. P., Cunningham, G. R., Hayes, F. J., Hodis, H. N., Matsumoto, A. M., Snyder, P. J., Swerdloff, R. S., Wu, F. C., & Yialamas, M. A. (2018). Testosterone therapy in men with Hypogonadism: An Endocrine Society clinical practice guideline. The Journal of Clinical Endocrinology and Metabolism, 103(5), 1715–1744. https://doi.org/10.1210/jc.2018-00229.
Palmert, M. R., & Dunkel, L. (2012). Clinical practice. Delayed puberty. The New England Journal of Medicine, 366(5), 443–453. https://doi.org/10.1056/NEJMcp1109290.
Fleseriu, M., Hashim, I. A., Karavitaki, N., Melmed, S., Murad, M. H., Salvatori, R., et al. (2016). Hormonal replacement in hypopituitarism in adults: An Endocrine Society clinical practice guideline. The Journal of Clinical Endocrinology and Metabolism, 101(11), 3888–3921. https://doi.org/10.1210/jc.2016-2118.
Moskowitz, C. S., Chou, J. F., Sklar, C. A., Barnea, D., Ronckers, C. M., Friedman, D. N., Neglia, J. P., Turcotte, L., Howell, R. M., Henderson, T. O., Armstrong, G. T., Leisenring, W. M., Robison, L. L., van Leeuwen, F. E., Pike, M. C., & Oeffinger, K. C. (2017). Radiation-associated breast cancer and gonadal hormone exposure: A report from the childhood Cancer survivor study. British Journal of Cancer, 117, 290–299. https://doi.org/10.1038/bjc.2017.169.
Kenney, L. B., Cohen, L. E., Shnorhavorian, M., Metzger, M. L., Lockart, B., Hijiya, N., et al. (2012). Male reproductive health after childhood, adolescent, and young adult cancers: A report from the Children's oncology group. J.Clin.Oncol, 30(27), 3408–3416. https://doi.org/10.1200/JCO.2011.38.6938.
Metzger, M. L., Meacham, L. R., Patterson, B., Casillas, J. S., Constine, L. S., Hijiya, N., et al. (2013). Female reproductive health after childhood, adolescent, and young adult cancers: Guidelines for the assessment and management of female reproductive complications. J.Clin.Oncol, 31(9), 1239–1247. https://doi.org/10.1200/JCO.2012.43.5511.
Alexandroni, H., Shoham, G., Levy-Toledano, R., Nagler, A., Mohty, M., Duarte, R., Leong, M., & Shoham, Z. (2019). Fertility preservation from the point of view of hematopoietic cell transplant specialists-a worldwide-web-based survey analysis. Bone Marrow Transplantation, 54, 1747–1755. https://doi.org/10.1038/s41409-019-0519-z.
Wasilewski-Masker, K., Kaste, S. C., Hudson, M. M., Esiashvili, N., Mattano, L. A., & Meacham, L. R. (2008). Bone mineral density deficits in survivors of childhood cancer: Long-term follow-up guidelines and review of the literature. Pediatrics, 121(3), e705–e713. https://doi.org/10.1542/peds.2007-1396.
Carpenter, P. A., Hoffmeister, P., Chesnut 3rd, C. H., Storer, B., Charuhas, P. M., Woolfrey, A. E., et al. (2007). Bisphosphonate therapy for reduced bone mineral density in children with chronic graft-versus-host disease. Biology of Blood and Marrow Transplantation, 13(6), 683–690. https://doi.org/10.1016/j.bbmt.2007.02.001.
Marini, J. C. (2003). Do bisphosphonates make children's bones better or brittle? The New England Journal of Medicine, 349(5), 423–426. https://doi.org/10.1056/NEJMp038103.
Blaser, B. W., Kim, H. T., Alyea 3rd, E. P., Ho, V. T., Cutler, C., Armand, P., et al. (2012). Hyperlipidemia and statin use after allogeneic hematopoietic stem cell transplantation. Biology of Blood and Marrow Transplantation, 18(4), 575–583. https://doi.org/10.1016/j.bbmt.2011.08.003.
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The authors would like to acknowledge Nisha Badders, PhD, ELS, for her assistance with editing the manuscript.
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Paetow, U., Bader, P. & Chemaitilly, W. A systematic approach to the endocrine care of survivors of pediatric hematopoietic stem cell transplantation. Cancer Metastasis Rev 39, 69–78 (2020). https://doi.org/10.1007/s10555-020-09864-z
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DOI: https://doi.org/10.1007/s10555-020-09864-z