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Dissecting the role of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) in colon, breast, and lung carcinogenesis

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Abstract

Peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) is a promising drug target since its agonists increase serum high-density lipoprotein; decrease low-density lipoprotein, triglycerides, and insulin associated with metabolic syndrome; improve insulin sensitivity; and decrease high fat diet-induced obesity. PPARβ/δ agonists also promote terminal differentiation and elicit anti-inflammatory activities in many cell types. However, it remains to be determined whether PPARβ/δ agonists can be developed as therapeutics because there are reports showing either pro- or anti-carcinogenic effects of PPARβ/δ in cancer models. This review examines studies reporting the role of PPARβ/δ in colon, breast, and lung cancers. The prevailing evidence would suggest that targeting PPARβ/δ is not only safe but could have anti-carcinogenic protective effects.

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Acknowledgments

Our research is supported by the National Institutes of Health (CA124533, CA126826, CA141029, CA140369, AA018863) J.M.P. and the National Cancer Institute Intramural Research Program (ZIABC005561, ZIABC005562, ZIABC005708) F.J.G.

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  1. Department of Veterinary and Biomedical Sciences and The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA, 16802, USA

    Jeffrey M. Peters & Jennifer E. Foreman

  2. Laboratory of Metabolism, National Cancer Institute, Bethesda, MD, USA

    Frank J. Gonzalez

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  1. Jeffrey M. Peters
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  2. Jennifer E. Foreman
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Correspondence to Jeffrey M. Peters.

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Peters, J.M., Foreman, J.E. & Gonzalez, F.J. Dissecting the role of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) in colon, breast, and lung carcinogenesis. Cancer Metastasis Rev 30, 619–640 (2011). https://doi.org/10.1007/s10555-011-9320-1

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