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Functional significance of vascular endothelial growth factor receptors on gastrointestinal cancer cells

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Abstract

Vascular endothelial growth factor (VEGF) has been shown to be the major mediator of physiologic and pathologic angiogenesis. VEGF was initially thought to be an endothelial cell specific ligand, but recently, VEGF has been shown to mediate tumor cell function via activation of receptors on tumor cells themselves. Here, we review the expression patterns and binding profiles of the VEGF receptors and their ligands on gastrointestinal tumor cells. Furthermore, we describe the current knowledge in regards to the function of these receptors on tumor cells. Elucidating the function of VEGF receptors on tumor cells should help us to better understand the potential mechanisms of action of anti-VEGF therapies.

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Authors and Affiliations

  1. Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA

    Nikolaos A. Dallas, Michael J. Gray, George Van Buren II & Sherry J. Lim

  2. Department of Cancer Biology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA

    Fan Fan & Ling Xia

  3. Departments of Surgical Oncology and Cancer Biology, Unit 444, The University of Texas M. D. Anderson Cancer Center, P.O. Box 301402, Houston, TX, 77230-1402, USA

    Lee M. Ellis

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  1. Nikolaos A. Dallas
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  2. Fan Fan
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Dallas, N.A., Fan, F., Gray, M.J. et al. Functional significance of vascular endothelial growth factor receptors on gastrointestinal cancer cells. Cancer Metastasis Rev 26, 433–441 (2007). https://doi.org/10.1007/s10555-007-9070-2

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