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Molecular mechanisms of metastasis

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Abstract

A major topic covered at the First International Symposium on Cancer Metastasis and the Lymphovascular System was the molecular mechanisms of metastasis. This has become of major interest in recent years as we have discovered new metastasis-related genes and gained understanding of the molecular events of lymphatic metastasis. The symposium covered new aspects and important questions related to the events of metastasis in both humans and animals. The basic and clinical related research covered in this topic represented many disciplines. The presentations showed novel findings and at the same time, raised many new unanswered questions, indicating the limited knowledge we still have regarding the molecular events of metastasis. The hope is that further unraveling of the direct and indirect molecular events of lymphatic metastasis will lead to new approaches in developing effective therapeutics.

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Authors and Affiliations

  1. Department of Molecular Oncology, John Wayne Cancer Institute, Santa Monica, CA, 90404, USA

    Dave S. B. Hoon, Minoru Kitago, Joseph Kim & Takuji Mori

  2. Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Adriano Piris, Katherine Szyfelbein & Martin C. Mihm Jr.

  3. Josephine Ford Cancer Center, Henry Ford Health System, 2799 W.Grand Blvd., Detroit, MI, 48301, USA

    S. David Nathanson

  4. E.L. Steele Laboratories for Tumor Biology, Radiation Oncology, Massachusetts General Hospital, Boston, MA, 02114, USA

    Timothy P. Padera

  5. London Regional Cancer Program, 790 Commissioners Road East, London, Ontario, N6A 4L6, Canada

    Ann F. Chambers & Sharon A. Vantyghem

  6. Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada, N6A 5C1

    Ian C. MacDonald

  7. Lakeland Regional Cancer Center, 300 Parkview Place, P.O. Box 95448, Lakeland, FL, 33805, USA

    Steven C. Shivers, Marwan Alsarraj & Douglas S. Reintgen

  8. Department of Thoracic Surgery, Albert-Ludwigs-University Freiburg, Hugstetter Str. 55, 79106, Freiburg, Germany

    Bernward Passlick & Wulf Sienel

  9. Institute of Tumor Biology, University Medical Center, Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany

    Klaus Pantel

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  1. Dave S. B. Hoon
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Correspondence to Dave S. B. Hoon.

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Presented as Session III of the First International Symposium on Cancer Metastasis and the Lymphovascular System. April 28–30, 2005, San Francisco, CA; Chaired by Dave S.B. Hoon.

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Hoon, D.S.B., Kitago, M., Kim, J. et al. Molecular mechanisms of metastasis. Cancer Metastasis Rev 25, 203–220 (2006). https://doi.org/10.1007/s10555-006-8500-x

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