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Integrin-dependent signal transduction regulating cyclin D1 expression and G1 phase cell cycle progression

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Abstract

Integrins and growth factor receptors coordinately regulate proliferation in nontransformed cells. Coordinate signaling from these receptors controls the activation of the G1 phase cyclin-dependent kinases, largely by regulating levels of cyclin D1 and p27kip1. Induction of cyclin D1 is one of the best understood examples of an integrin/growth factor receptor-regulated G1 phase target. This review focuses on the integrin-dependent signal transduction events that regulate the expression of cyclin D1 during G1 phase.

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  1. Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104-6084

    Janice L. Walker & Richard K. Assoian

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Walker, J.L., Assoian, R.K. Integrin-dependent signal transduction regulating cyclin D1 expression and G1 phase cell cycle progression. Cancer Metastasis Rev 24, 383–393 (2005). https://doi.org/10.1007/s10555-005-5130-7

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