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The relationship between triglyceride/high-density lipoprotein cholesterol ratio and coronary slow-flow phenomenon

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Abstract

In this study, we aimed to investigate the relationship between high triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) ratio and coronary slow flow phenomenon (CSFP) in patients undergoing elective coronary angiography for suspected coronary artery disease. This prospective study included a total of 84 CSFP patients and 83 controls with normal coronary flow, as evidenced by coronary angiography. The Thrombolysis in Myocardial Infarction (TIMI) frame count (TFC) was used to measure the coronary blood flow velocity. The lipid profiles were analyzed and TG/HDL-C ratio were calculated dividing absolute TG levels by absolute HDL-C levels in peripheral blood. The median TG/HDL-C ratio was higher in the CSFP group than the control group (3.4 [2.6 to 4.9] vs. 2.3 [1.8 to 3], respectively; p < 0.001). The multivariate logistic regression analysis revealed that TG/HDL-C ratio was an independent predictor of CSFP (odds ratio [OR] 1.78, 95% confidence interval [CI] 1.59–2.32; p = 0.001) and TG/HDL-C ratio was positively correlated with the TFC in the CSFP group (r = 0.311, p < 0.001). The area under the receiver operating characteristic curve of TG/HDL-C for the diagnosis of CSFP was 0.73 (95% CI 0.65–0.81; p < 0.001). If a cut-off value of 2.75 was used, higher levels of TG/HDL-C ratio could predict the presence of CSFP with 72% sensitivity and 71% specificity. Our study results suggest that TG/HDL-C ratio is associated with CSFP and may be a useful biomarker for predicting CSFP and its severity.

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Funding

This study received no specific grant from any funding agency in the public, commercial or not‐for‐profit sectors.

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Authors and Affiliations

  1. Department of Cardiology, Istanbul Medeniyet University, Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Istanbul, Turkey

    Gonul Aciksari, Adem Atici, Fatma Betul Celik & Mustafa Caliskan

  2. Department of Cardiology, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey

    Gokhan Cetinkal

  3. Department of Emergency Medicine, Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkey

    Mehmet Kocak

Authors
  1. Gonul Aciksari
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  2. Gokhan Cetinkal
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  3. Mehmet Kocak
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  4. Adem Atici
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  5. Fatma Betul Celik
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  6. Mustafa Caliskan
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Contributions

Conceptualization: GA, AA, Methodology: GA, AA, GC, Formal analysis: AA, GC, MK, Data collection: FBC, AA, Data interpretation: AA, GC, FBC, Writing: GA, MC, Original draft: FBC, AA, MK, Review & editing: MC. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Gonul Aciksari.

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Conflict of interest

The authors declare they have no potential conflict of interest regarding the investigation, authorship, and/or publication of this article.

Ethical Approval

This study was approved by the Istanbul Medeniyet University, Goztepe Prof. Dr. Süleyman Yalcin City Hospital, Ethics Committee with the Approval No. 2019/0447.

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Aciksari, G., Cetinkal, G., Kocak, M. et al. The relationship between triglyceride/high-density lipoprotein cholesterol ratio and coronary slow-flow phenomenon. Int J Cardiovasc Imaging 38, 5–13 (2022). https://doi.org/10.1007/s10554-021-02387-w

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  • DOI: https://doi.org/10.1007/s10554-021-02387-w

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