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Global myocardial longitudinal strain in a general population—associations with blood pressure and subclinical heart failure: The Tromsø Study

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Abstract

The early detection of subclinical myocardial dysfunction can contribute to the treatment and prevention of heart failure (HF). The aim of the study was to (i) describe myocardial global longitudinal strain (GLS) patterns in a large general population sample from Norway and their relation to established cardiovascular disease (CVD) risk factors; (ii) to determine its normal thresholds in healthy individuals and (iii) ascertain the relation of myocardial GLS to stage A subclinical heart failure (SAHF). Participants (n = 1855) of the 7th survey of the population-based Tromsø Study of Norway (2015–2016) with GLS measurements were studied. Linear and logistic regression models were used for assessment of the associations between CVD risk factors and GLS. Mean GLS (SD) in healthy participants was − 15.9 (2.7) % in men and − 17.8 (3.1) % in women. Among healthy subjects, defined as those without known cardiovascular diseases and comorbidities, GLS declined with age. An increase of systolic blood pressure (SBP) of 10 mm Hg was associated with a 0.2% GLS reduction. Myocardial GLS in individuals with SAHF was 1.2% lower than in participants without SAHF (p < 0.001). Mean myocardial GLS declines with age in both sexes, both in a general population and in the healthy subsample. SBP increase associated with GLS decline in women. Our findings indicate high sensitivity of GLS for early subclinical stages of HF.

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Acknowledgements

Current study was supported by UiT-The Arctic University of Norway, Tromsø.

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Authors and Affiliations

  1. Department of Community Medicine, UiT The Arctic University of Norway, 9037, Tromsø, Norway

    Michael Stylidis & David A. Leon

  2. Department of Non-Communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK

    David A. Leon

  3. Department of Clinical Medicine, UiT The Arctic University of Norway, Tromsø, Norway

    Assami Rӧsner & Henrik Schirmer

  4. Department of Cardiology, University Hospital of North Norway, Tromsø, Norway

    Assami Rӧsner

  5. Institute of Clinical Medicine, University of Oslo, Oslo, Norway

    Henrik Schirmer

  6. Akershus University Hospital, Lørenskog, Norway

    Henrik Schirmer

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Correspondence to Michael Stylidis.

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The Tromsø Study protocol was approved by the Regional Committee for Medical and Health Research Ethics, North Norway (2014/940/REK Nord) and was performed according ethical standards outlined in the 1964 Declaration of Helsinki.

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Stylidis, M., Leon, D.A., Rӧsner, A. et al. Global myocardial longitudinal strain in a general population—associations with blood pressure and subclinical heart failure: The Tromsø Study. Int J Cardiovasc Imaging 36, 459–470 (2020). https://doi.org/10.1007/s10554-019-01741-3

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