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Acknowledgements
We acknowledge the gift of this human heart for research from the organ donor/donor family as well as LifeSource for their assistance in organ recovery. We further acknowledge Dr. Brian Bagley and the X-ray Computed Tomography Laboratory in the Department of Earth Sciences, University of Minnesota, for technical assistance in micro-CT imaging. This work was funded by the Institute for Engineering in Medicine at the University of Minnesota and a research contract with Medtronic. CoreValve Evolut™ R is an FDA-approved and market released product in the United States.
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All authors contributed to the conception, design, and setup of this study. JDZS: Drafted manuscript, created TAVR video, prepared TAVR device and delivery system, imaged heart specimen, reconstruction and modeling, 3D printing. MGB: Edited manuscript and video, selected/implanted TAVR, imaged heart specimen, post-implant imaging analyses. PAI: Final revision and approval of manuscript and video, reanimated heart specimen, implanted TAVR, multimodal imaging of TAVR procedure.
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PA Iaizzo has a research contract and education consultant arrangement with Medtronic. MG Bateman has ownership interest in Medtronic. JD Zhingre Sanchez has no conflicts of interest to declare.
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This article does not contain any studies with human participants or animals performed by any of the authors.
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LifeSource secured consent from the organ donor’s family to use this heart for research.
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Zhingre Sanchez, J.D., Bateman, M.G. & Iaizzo, P.A. Multimodal imaging of a self-expanding transcatheter aortic valve replacement (TAVR) procedure in a reanimated human heart and post-implant analyses. Int J Cardiovasc Imaging 35, 2135–2137 (2019). https://doi.org/10.1007/s10554-019-01645-2
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DOI: https://doi.org/10.1007/s10554-019-01645-2