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Prevalence and morphology of myocardial crypts in normal and hypertrophied myocardium by computed tomography

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Abstract

Myocardial crypts can be recognized in patients with hypertrophic cardiomyopathy (HCM) using magnetic resonance imaging, but similar studies using computed tomography (CT) are sparse. The aim of the present study was to evaluate the prevalence and morphology of myocardial crypts in patients with HCM, arterial hypertension, and aortic valve stenosis using contrast-enhanced CT. We also investigated the added value of a finding of myocardial crypts on CT scan to the diagnosis of HCM. The study cohort included 73 patients with HCM, 100 patients with arterial hypertension, 120 patients with aortic valve stenosis, and 100 subjects without cardiovascular disease (normal control group). All underwent evaluation for the presence and dimensions of myocardial crypts using 256-slice CT. Crypts were identified in 18 patients (24.7%) with HCM, 7 patients (7%) with hypertension, 8 patients (6.7%) with aortic valve stenosis, and 4 (4%) normal subjects (P < 0.001). Values of crypt length, width, area, and penetration into myocardium were highest in the HCM group. Crypt area differentiated patients with HCM from patients with arterial hypertension and aortic valve stenosis, and from normal control subjects. Crypt area was an accurate predictor of HCM, with an area under the receiver-operator characteristic curve of 0.88 (95% CI 0.80–0.96). Myocardial crypts identified by CT are more prevalent and larger in area in HCM than in arterial hypertension and aortic valve stenosis. Crypt area could potentially help to improve the diagnosis of HCM by CT beyond the assessment of left ventricular thickness or mass.

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Authors and Affiliations

  1. Department of Cardiology, Rabin Medical Center – Beilinson Hospital, 49100, Petach Tikva, Israel

    Ziad Arow, Mithal Nassar, Daniel Monakier, Abid Assali, Hana Vaknin-Assa, Ran Kornowski & Ashraf Hamdan

  2. Affiliated to Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

    Ziad Arow, Mithal Nassar, Daniel Monakier, Abid Assali, Hana Vaknin-Assa, Ran Kornowski & Ashraf Hamdan

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  1. Ziad Arow
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  2. Mithal Nassar
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Correspondence to Ashraf Hamdan.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. For this type of study, formal consent is not required.

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Arow, Z., Nassar, M., Monakier, D. et al. Prevalence and morphology of myocardial crypts in normal and hypertrophied myocardium by computed tomography. Int J Cardiovasc Imaging 35, 1347–1355 (2019). https://doi.org/10.1007/s10554-019-01543-7

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  • DOI: https://doi.org/10.1007/s10554-019-01543-7

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