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The comparison of short-term prognostic value of T1 mapping with feature tracking by cardiovascular magnetic resonance in patients with severe dilated cardiomyopathy

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Abstract

To evaluate and compare the prognostic value of T1 mapping with feature tracking cardiovascular magnetic resonance (FT-CMR) imaging in patients with severe dilated cardiomyopathy (DCM) during short-term follow-up. A total of 46 patients with severe DCM (LVEF < 35%) underwent 3.0-T CMR with T1 mapping and FT-CMR analysis. The study end-point was defined as a combination of cardiac death, heart transplantation, and hospitalization due to cardiovascular events. The significance of the risk factors was mainly evaluated by univariate and multivariate Cox model analyses. During the median follow-up of 13 months (interquartile range 7–17 months), two patients died of heart failure, one received a heart transplantation, and six were hospitalized for heart failure. In the univariate analysis, extracellular volume fraction (ECV) showed significant predictive association with cardiovascular events (hazard ratio [HR] 1.35; 95% confidence interval [CI] 1.13–1.62; P = 0.001). No strain parameters in FT-CMR differed significantly between patients with or without events (all P > 0.05). In the multivariate analyses, ECV was the sole independent predictor of cardiovascular events (HR, 1.48; 95% CI 1.13–1.94; P = 0.005). The area under the curve of the time-dependent receiver operating characteristic in leave-one-out cross-validation (all > 0.70) further confirmed the predictive significance of ECV. In patients with severe DCM, ECV was not only a strong independent predictor of adverse cardiovascular events but also provided prognostic value prior to strain parameters of the FT-CMR in the short term.

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Abbreviations

DCM:

Dilated cardiomyopathy

CMR:

Cardiovascular magnetic resonance

LVEF:

Left ventricular ejection fraction

LVEDVI:

Left ventricular end-diastolic volume index

LGE:

Late gadolinium enhancement

ECV:

Extracellular volume fraction

FT-CMR:

Feature tracking cardiovascular magnetic resonance

STE:

Speckle tracking echocardiography

GLS:

Global longitudinal strain

GCS:

Global circumferential strain

IQR:

Interquartile range

ROI:

Region of interest

ROC:

Receiver operating characteristic

AUC:

Area under the curve

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Acknowledgements

The study received funding from the National Natural Science Foundation of China (No. 81771799), Guangdong Provincial Science and Technology Planning Project (No. 2014A020212676), and Science and Technology Program of Guangzhou, China (No. 201707010306).

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Authors and Affiliations

  1. School of Medicine, South China University of Technology, Guangzhou, 510006, China

    Rui Chen, Jingjing Wang, Yulei Zhu, Changhong Liang, Zhuliang Yu & Hui Liu

  2. Department of Radiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, 106 Zhong Shan Er Lu, Guangzhou, 510080, Guangdong, China

    Rui Chen, Jingjing Wang, Wanjia Wu, Yulei Zhu, Changhong Liang & Hui Liu

  3. Department of Medical Statistics and Epidemiology, Health Information Research Center, Guangdong Key Laboratory of Medicine, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, China

    Zhicheng Du

  4. Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital, Linkou, Chang Gung University, Taoyuan, Taiwan

    Yu-Hsiang Juan

  5. Division of Cardiology, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Rm 1929b, Block K, Hong Kong, China

    Carmen Wing-Sze Chan

  6. Department of Cardiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China

    Hongwen Fei, Liwen Li, Jinxiu Meng, Shulin Wu & Hui Liu

  7. Department of Radiology, The Second Affiliated Hospital, South China University of Technology, Guangzhou, Guangdong, China

    Jiajun Xie

  8. College of Automation Science and Technology, South China University of Technology, Guangzhou, Guangdong, China

    Zhuliang Yu

Authors
  1. Rui Chen
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  2. Jingjing Wang
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  9. Yulei Zhu
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  10. Liwen Li
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  15. Hui Liu
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Contributions

RC drafted the manuscript; JW, JX and WW acquired the data; YHJ, CWSC, HF, LL, JM, SW, CL revised the manuscript; RC, ZD, YZ and ZY provided the analysis method. HL provided the conception and design of the study.

Corresponding author

Correspondence to Hui Liu.

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The authors declare no conflicts of interest.

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Chen, R., Wang, J., Du, Z. et al. The comparison of short-term prognostic value of T1 mapping with feature tracking by cardiovascular magnetic resonance in patients with severe dilated cardiomyopathy. Int J Cardiovasc Imaging 35, 171–178 (2019). https://doi.org/10.1007/s10554-018-1444-8

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  • DOI: https://doi.org/10.1007/s10554-018-1444-8

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