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Accuracy of coronary computed tomography angiography for bioresorbable scaffold luminal investigation: a comparison with optical coherence tomography

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Abstract

To establish the accuracy of coronary computed tomography angiography (CTA) for in-scaffold quantitative evaluation with optical coherence tomography (OCT) as a reference. The translucent backbone of the bioresorbable scaffold allow us to evaluate non-invasively the coronary lumen with coronary CTA. In the ABSORB first-in-man studies, coronary CTA was shown to be feasible for quantitative luminal assessment. Nevertheless, a comparison with an intravascular modality with higher resolution has never been performed. In the ABSORB Cohort B trial, 101 patient with non-complex lesions were treated with the fully biodegradable vascular scaffold. For this analysis, all patients who underwent coronary CTA at 18 months and OCT within ±180 days were included. Coronary CTA and OCT data were analysed at an independent core laboratory for quantitative cross-sectional luminal dimensions. The primary objective was the accuracy and precision of coronary CTA for in-scaffold minimal lumen area assessment, with OCT as a reference. Among the 101 patients of the ABSORB Cohort B trial, 35 underwent both OCT and coronary CTA. The feasibility of quantitative evaluation was 74%. In the scaffolded segment, coronary CTA underestimated minimal lumen area by 9.8% (accuracy 0.39 mm2, precision 1.0 mm2, 95% limits of agreement −1.71 to 2.50 mm2). A similar level of agreement was observed in the non-scaffolded segment. Compared to OCT, coronary CTA appears to be accurate for the estimation of in-scaffold luminal areas, with no difference compared to the non-scaffolded region.

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Abbreviations

BVS:

Bioresobable vascular scaffold

CTA:

Computed tomography angiography

IVUS:

Intravascular ultrasound

FFRCT :

Fractional flow reserve derived from computed tomography

OCT:

Optical coherence tomography

PCI:

Percutaneous coronary interventions

PLLA:

Poly-l-lactide

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Authors and Affiliations

  1. Cardiology Department, Academic Medical Centre, Amsterdam, The Netherlands

    Carlos Collet, Yohei Sotomi, Taku Asano & Robbert J. de Winter

  2. ThoraxCenter, Erasmus University Medical Centre, Rotterdam, The Netherlands

    Rafael Cavalcante, Yosuke Miyazaki, Erhan Tenekecioglu, Yaping Zeng, Koen Nieman & Yoshinobu Onuma

  3. Division of Image Processing, Department of Radiology, Leiden University, Leiden, The Netherlands

    Pieter Kistlaar

  4. Medis medical imaging systems BV, Leiden, The Netherlands

    Pieter Kistlaar

  5. Northern Region Heart Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

    Pannipa Suwanasson

  6. Imperial College of London, London, UK

    Patrick W. Serruys

  7. Cardialysis BV, Rotterdam, The Netherlands

    Yoshinobu Onuma

Authors
  1. Carlos Collet
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  2. Yohei Sotomi
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  3. Rafael Cavalcante
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  4. Taku Asano
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  5. Yosuke Miyazaki
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  6. Erhan Tenekecioglu
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  7. Pieter Kistlaar
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  8. Yaping Zeng
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  9. Pannipa Suwanasson
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  10. Robbert J. de Winter
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  11. Koen Nieman
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  12. Patrick W. Serruys
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  13. Yoshinobu Onuma
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Corresponding author

Correspondence to Patrick W. Serruys.

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Conflict of interest

Y. Onuma and P.W. Serruys are members of International Advisory Board of Abbott Vascular. Y. Sotomi is a consultant for GOODMAN and has received a grant from the Fukuda Memorial Foundation and SUNRISE laboratory. P.H. Kitslaar is an employee of Medis medical imaging systems and has a research appointment at the Leiden University Medical Center. All other authors declare no competing interests.

Additional information

Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique identifier: NCT00856856.

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Collet, C., Sotomi, Y., Cavalcante, R. et al. Accuracy of coronary computed tomography angiography for bioresorbable scaffold luminal investigation: a comparison with optical coherence tomography. Int J Cardiovasc Imaging 33, 431–439 (2017). https://doi.org/10.1007/s10554-016-1018-6

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  • DOI: https://doi.org/10.1007/s10554-016-1018-6

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