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T1 mapping in children and young adults with hypertrophic cardiomyopathy

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Abstract

To assess the global and segmental left ventricular (LV) native T1 and extracellular volume fraction (ECV) in children and young adults with hypertrophic cardiomyopathy (HCM) compared to a control cohort. The study population included 21 HCM patients (mean 14.1 ± 4.6 years) and 21 controls (mean 15.7 ± 1.5 years). Native modified Look-Locker inversion recovery sequence was performed before and after contrast injection in 3 short axis planes. Global and segmental LV native T1 and ECV were quantified and compared between HCM patients and controls. Mean native T1 in HCM patients and controls was 1020.4 ± 41.2 and 965.6 ± 30.2 ms respectively (p < 0.0001). Hypertrophied myocardium had significantly higher native global T1 and global ECV compared to non-hypertrophied myocardium in HCM (p < 0.0001, = 0.14 and 0.048, = 0.01 respectively). In a subset of patients, ECV was higher in LV segments with LGE compared to no LGE (p < 0.0001). No significant correlation was identified between global native T1 and ECV and parameters of LV structure and function. Native T1 cut-off of 987 ms provided the highest sensitivity (95 %) and specificity (91 %) to separate HCM patients from controls. Global and segmental native T1 are elevated in HCM patients. LV segments with hypertrophy and/or LGE had higher ECV in a subset of HCM patients. LV native T1 and ECV do not correlate with parameters of LV structure and function. T1 in children and young adults may be used as a non-invasive tool to assess for HCM and related fibrosis.

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Acknowledgments

We thank Samantha Schoeneman, BA, Marci Messina, RT®(MR), and Brian Reilly, RT for their assistance with this project. Support by the the National Institutes of Health (NHLBI1R01 HL117888).

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Authors and Affiliations

  1. Department of Medical Imaging, Ann and Robert H. Lurie Children’s Hospital of Chicago, 225 East Chicago Avenue, Chicago, IL, 60611, USA

    Keyur Parekh, Jie Deng, Roger A. de Freitas & Cynthia K. Rigsby

  2. Department of Radiology, Feinberg School of Medicine, Northwestern University, 225 East Chicago Avenue, Chicago, IL, 60611, USA

    Keyur Parekh & Cynthia K. Rigsby

  3. Department of Radiology, Feinberg School of Medicine, Northwestern University, 737 N Michigan Avenue, Chicago, IL, 60611, USA

    Michael Markl

  4. Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, 737 N Michigan Avenue, Chicago, IL, 60611, USA

    Michael Markl

  5. Division of Pediatric Cardiology, Ann & Robert H. Lurie Children’s Hospital of Chicago, 225 East Chicago Avenue, Chicago, IL, 60611, USA

    Roger A. de Freitas

  6. Department of Pediatrics, Feinberg School of Medicine, Northwestern University, 225 East Chicago Avenue, Chicago, IL, 60611, USA

    Roger A. de Freitas

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  1. Keyur Parekh
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Correspondence to Keyur Parekh.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by an appropriate institutional review board.

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Informed consent was obtained from all individual participants included in the study.

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Parekh, K., Markl, M., Deng, J. et al. T1 mapping in children and young adults with hypertrophic cardiomyopathy. Int J Cardiovasc Imaging 33, 109–117 (2017). https://doi.org/10.1007/s10554-016-0979-9

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  • DOI: https://doi.org/10.1007/s10554-016-0979-9

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