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Influence of microvascular dysfunction on regional myocardial deformation post-acute myocardial infarction: insights from a novel angiographic index for assessing myocardial tissue-level reperfusion

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Abstract

To investigate the impact of microvascular dysfunction assessed by angiography on myocardial deformation assessed by two-dimensional speckle-tracking echocardiography in ST-segment elevation myocardial infarction (STEMI). A total of 121 STEMI patients who received primary percutaneous coronary intervention were included. Thrombolysis in myocardial infarction, Myocardial Perfusion Frame Count (TMPFC), a novel angiographic method to assess myocardial perfusion, was used to evaluate microvascular dysfunction. Two-dimensional speckle-tracking echocardiography was performed at 3–7 days after reperfusion. The infarction related regional longitudinal (RLS) strains as well as circumferential (RCS) and radial (RRS) ones, along with global longitudinal, circumferential (GCS), and radial (GRS) strains were measured. Patients with microvascular dysfunction had decreased peak amplitude of RLS (p = 0.012), RCS (p < 0.001), RRS (p = 0.012) at the regional level and decreased peak amplitude of GCS (p = 0.005), GRS (p = 0.012) at the global level. The RCS to RLS and RCS to RRS ratios were significantly different between patients without than with microvascular dysfunction (1.28 ± 0.31 vs. 1.07 ± 0.47, p = 0.027 and 0.69 ± 0.33 vs. 0.56 ± 0.28, p = 0.047). Receiver operator characteristics curves identified a cutoff value of 94 frames for TMPFC to differentiate between normal and abnormal wall motion score index in the sub-acute phase of STEMI (AUC = 0.72; p < 0.001). In the sub-acute phase of STEMI, the presence of microvascular dysfunction in infarcted tissue relates to reduced global and regional myocardial deformation. RCS alterations were more significant than RLS and RRS between patients with than without microvascular dysfunction. TMPFC was useful to predict left ventricular systolic dysfunction in the sub-acute phase of STEMI.

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Acknowledgments

This work was supported by National Natural Science Foundation of China (81270282, 81330006 and 81400261), Shanghai Leading Talents Program (LJ10007), Program for New Century Excellent Talents in University from Ministry of Education of China (NCET-12-0352), Shanghai Shuguang Program (12SG22), Program of Shanghai Committee of Science and Technology (15411963600 and 14JC1404500), Shanghai Emerging Technology Program (SHDC12013119), Shanghai Municipal Education Commission Gaofeng Clinical Medicine Grant Support (20152209), Shanghai Jiaotong University (YG2013MS420) and Shanghai Jiaotong University School of Medicine (15ZH1003 and 14XJ10019).

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  1. Department of Cardiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, 160 Pujian Road, Shanghai, 200127, China

    Ben He, Song Ding, Zhiqing Qiao, Lincheng Gao, Wei Wang, Heng Ge, Xuedong Shen & Jun Pu

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  1. Ben He
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  2. Song Ding
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  3. Zhiqing Qiao
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  8. Jun Pu
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Correspondence to Jun Pu.

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He, B., Ding, S., Qiao, Z. et al. Influence of microvascular dysfunction on regional myocardial deformation post-acute myocardial infarction: insights from a novel angiographic index for assessing myocardial tissue-level reperfusion. Int J Cardiovasc Imaging 32, 711–719 (2016). https://doi.org/10.1007/s10554-015-0834-4

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