Skip to main content
SpringerLink
Log in

Arterial stiffness as a predictor of recovery of left ventricular systolic function after acute myocardial infarction treated with primary percutaneous coronary intervention

  • Original Paper
  • Published:
The International Journal of Cardiovascular Imaging Aims and scope Submit manuscript

Abstract

Left ventricular ejection fraction (LVEF) and pulse wave velocity (PWV) are acknowledged as independent risk factors in different high-risk populations. We investigated the effects of arterial stiffness on LV function at 3 and 6 months after acute myocardial infarction. Changes in LVEF were evaluated in 136 consecutive patients who were diagnosed with ST-segment elevation coronary syndrome and treated with primary percutaneous coronary intervention. Doppler guided by 2D ultrasound was used to measure carotid-femoral PWV. According to tertiles of arterial stiffness, a significant correlation between higher PWV and worse recovery in LVEF was found (3 months EF change: 9.9 ± 5.0 % vs 5.9 ± 3.4 vs 3.8 ± 1.6; p < 0.001 and 6 months EF change: 18.5 ± 7.0 % vs 11.5 ± 5.2 vs 7.3 ± 3.0; p = 0.002). In the multivariate analysis PWV showed the ability to predict the outcome in terms of EF recovery at 3 and 6 months also after any correction for age and other variables (β = −0.566, p < 0.001). Arterial stiffening may result in a less effective recovery of LV function after acute myocardial infarction.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Haim M, Battler A, Behar S et al (2004) Acute coronary syndromes complicated by symptomatic and asymptomatic heart failure: does current treatment comply with guidelines? Am Heart J 147:859–864

    Article  PubMed  Google Scholar 

  2. John Sutton M, Pfeffer MA, Plappert T et al (1994) Quantitative two-dimensional echocardiographic measurements are major predictors of adverse cardiovascular events after acute myocardial infarction. Circulation 89:68–75

    Article  Google Scholar 

  3. Antoni ML, Mollema SA, Atary JZ et al (2010) Time course of global left ventricular strain after acute myocardial infarction. Eur Heart J 31:2006–2013

    Article  PubMed  Google Scholar 

  4. Laurent S, Cockcroft J, Van Bortel L, Boutouyrie P, Giannattasio C, Hayoz D, Pannier B, Vlachopoulos C, Wilkinson I, Struijker-Boudier H (2006) European network for non-invasive investigation of large arteries: expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J 27(21):2588–2605

    Article  PubMed  Google Scholar 

  5. Vlachopoulos C, Aznaouridis K, Stefanadis C (2010) Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis. J Am Coll Cardiol 55(13):1318–1327

    Article  PubMed  Google Scholar 

  6. Ben-Shlomo Y, Spears M, Boustred C, May M, Anderson SG, Benjamin EJ, Boutouyrie P, Cameron J, Chen CH, Cruickshank JK, Hwang SJ, Lakatta EG, Laurent S, Maldonado J, Mitchell GF, Najjar SS, Newman AB, Ohishi M, Pannier B, Pereira T, Vasan RS, Shokawa T, Sutton-Tyrell K, Verbeke F, Wang KL, Webb DJ, Willum Hansen T, Zoungas S, McEniery CM, Cockcroft JR, Wilkinson IB (2014) Aortic pulse wave velocity improves cardiovascular event prediction: an individual participant meta-analysis of prospective observational data from 17,635 subjects. J Am Coll Cardiol 63(7):636–646

    Article  PubMed Central  PubMed  Google Scholar 

  7. Ghali JK, Liao Y, Simmons B (1992) The prognostic role of LV hypertrophy in subjects with or without coronary artery disease. Ann Intern Med 117:831

    Article  CAS  PubMed  Google Scholar 

  8. Fouad-Tarazi FM (1994) Left ventricular diastolic dysfunction in hypertension. Current Opin Cardiol 9:551–560

    Article  CAS  Google Scholar 

  9. Steg G, James SK, Atar D et al (2012) ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. Eur Heart J 33:2569–2619

    Article  CAS  PubMed  Google Scholar 

  10. Schiller NB, Shah PM, Crawford M et al (1989) Recommendations for quantitation of the left ventricle by two-dimensional echocardiography: American Society of Echocardiography Committee on standards, subcommittee on quantitation of two-dimensional echocardiograms. J Am Soc Echocardiogr 2:358–367

    Article  CAS  PubMed  Google Scholar 

  11. Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, Picard MH, Roman MJ, Seward J, Shanewise J, Solomon S, Spencer KT, St John SM, Stewart W (2006) Recommendations for chamber quantification. Eur J Echocardiogr 7:79–108

    Article  PubMed  Google Scholar 

  12. Calabia J, Torguet P, Garcia M et al (2011) Doppler ultrasound in the measurement of pulse wave velocity: agreement with the Complior method. Cardiovascular Ultrasound 9:13

    Article  PubMed Central  PubMed  Google Scholar 

  13. Kass DA, Saeki A, Tunin RS, Recchia FA (1996) Adverse influence of systemic vascular stiffening on cardiac dysfunction and adaptation to acute coronary occlusion. Circulation 93:1533–1541

    Article  CAS  PubMed  Google Scholar 

  14. Benetos A, Rudnichi A, Safar M, Guize L (1998) Pulse pressure and cardiovascular mortality in normotensive and hypertensive subjects. Hypertension 32:560–564

    Article  CAS  PubMed  Google Scholar 

  15. Kass DA (2002) Age-related changes in venticular-arterial coupling: pathophysiologic implications. Heart Fail Rev 7:51–62

    Article  PubMed  Google Scholar 

  16. Kass DA (2005) Ventricular arterial stiffening: integrating the pathophysiology. Hypertension 46:185–193

    Article  CAS  PubMed  Google Scholar 

  17. Patrianakos AP, Parthenakis FI, Karakitsos D, Nyktari E, Vardas PE (2009) Proximal aortic stiffness is related to left ventricular function and exercise capacity in patients with dilated cardiomyopathy. Eur J Echocardiogr 10:425–432

    Article  PubMed  Google Scholar 

  18. Marinho NV, Keogh BE, Costa DC, Lammerstma AA, Ell PJ, Camici PG (1996) Pathophysiology of chronic left ventricular dysfunction: New insights from the measurement of absolute myocardial blood flow and glucose utilization. Circulation 93:737–744

    Article  CAS  PubMed  Google Scholar 

  19. Leite-Moreira AF, Correia-Pinto J, Gillebert TC (1999) Afterload induced changes in myocardial relaxation: a mechanism for diastolic dysfunction. Cardiovasc Res 43:344–353

    Article  CAS  PubMed  Google Scholar 

  20. Braunwald E, Kloner RA (1982) The stunned myocardium: prolonged, post ischemic ventricular dysfunction. Circulation 66:1146–1149

    Article  CAS  PubMed  Google Scholar 

  21. Gaudron P, Eilles C, Kochsiek K, Ertl G (1992) Compensatory and non compensatory left ventricular dilatation after myocardial infarction: time course and hemodynamic consequences atrest and during exercise. Am Heart J 123:377–385

    Article  CAS  PubMed  Google Scholar 

  22. Cuberas-Borrós G, Pineda V, Aguadé-Bruix S et al (2013) Gated-SPECT myocardial perfusion imaging as a complementary technique to magnetic resonance imaging in chronic myocardial infarction patients. Rev Esp Cardiol 66(9):721–727

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Clinical and Experimental Medicine, Policlinic University of Messina, Via Consolare Valeria n.1, 98125, Messina, Italy

    Egidio Imbalzano, Giuseppe Mandraffino, Sebastiano Gangemi, Rossella Costantino, Antonino Saitta & Giuseppe Dattilo

  2. UTIC and Cardiology, Hospital “Pugliese-Ciaccio”, Catanzaro, Italy

    Marco Vatrano, Vincenzo Antonio Ciconte & Roberto Ceravolo

  3. Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

    Lorenzo Ghiadoni

  4. Institute of Clinical Physiology, National Research Council, Pisa, Italy

    Rosa Maria Bruno

  5. Railway Health Care Institute, Belgrade, Serbia

    Nevena Paunovic

  6. Department of Biomedical Sciences and of Morphologic and Functional Images, University of Messina, Messina, Italy

    Enrico Maria Mormina

Authors
  1. Egidio Imbalzano
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Marco Vatrano
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Giuseppe Mandraffino
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Lorenzo Ghiadoni
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Sebastiano Gangemi
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Rosa Maria Bruno
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Vincenzo Antonio Ciconte
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Nevena Paunovic
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Rossella Costantino
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Enrico Maria Mormina
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Roberto Ceravolo
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Antonino Saitta
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Giuseppe Dattilo
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Egidio Imbalzano.

Ethics declarations

Conflict of interest

The authors have no conflict of interest to declare.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Imbalzano, E., Vatrano, M., Mandraffino, G. et al. Arterial stiffness as a predictor of recovery of left ventricular systolic function after acute myocardial infarction treated with primary percutaneous coronary intervention. Int J Cardiovasc Imaging 31, 1545–1551 (2015). https://doi.org/10.1007/s10554-015-0733-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10554-015-0733-8

Keywords

Search

Navigation