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Incidence and severity of atherosclerotic cardiovascular artery disease in patients undergoing TAVI

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Abstract

Transcatheter aortic valve implantation (TAVI) has extended the treatment options for severe, symptomatic aortic valve stenosis (AS). Risk factors for AS have been shown to be similar to atherosclerosis. Consequently, coronary artery disease (CAD), peripheral vascular and carotid artery diseases are often found concurrently with diagnostic, procedural and prognostic implications. This study sought to describe comprehensive vascular assessment in terms of prevalence, severity and correlations in TAVI candidates. A total of 323 patients (81 ± 6 years) undergoing TAVI were enrolled. Vascular pathologies were evaluated by invasive coronary angiography, computer-tomography (abdominal aorta, renal, iliac and femoral arteries), echo-color Doppler ultrasound (carotid artery), and transoesophageal echocardiography (thoracic aorta). CAD was found in 173 (54 %) patients, of which 65 (38 %) had 1-vessel, 45 (26 %) 2-vessel and 59 (34 %) 3-vessel disease. Carotid artery disease was present in 33.6 % patients, of which 23.6 % unilateral and 10.0 % bilateral. Iliac, femoral and renal stenosis were found in 29.2 %, 22.0 %, and 4.7 %, respectively. Cardiovascular risk factor and gender correlated with CAD. CAD patients presented more frequently with significant stenosis (luminal narrowing ≥50 %) of at least one other district. Multi-districts significant stenosis stratified patients on long-term survival and the coexistence of 3-districts involvement with CAD negatively impacts on mortality. Multimodality imaging assessment shows that coronary, carotid, and peripheral artery disease are often found concurrently in patients undergoing TAVI. Several risk factors and gender correlate with the presence and severity of CAD and peripheral pathologies. Long-term mortality is increased in patients with a more compromised vascular situation.

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Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Centro Cardiologico Monzino IRCCS, Milan, Italy

    Laura Fusini, Gloria Tamborini, Manuela Muratori, Paola Gripari, Claudia Cefalù, Sarah Ghulam Ali, Francesco Maffessanti, Daniele Andreini, Gianluca Pontone, Antonio L. Bartorelli, Francesco Alamanni, Marco Agrifoglio & Mauro Pepi

  2. Department of Cardiology, Emergency County Hospital Craiova, Craiova, Romania

    Oana Mirea

  3. Department of Clinical Sciences and Community Health, Cardiovascular Section, University of Milan, Milan, Italy

    Daniele Andreini, Antonio L. Bartorelli, Francesco Alamanni & Marco Agrifoglio

Authors
  1. Laura Fusini
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  2. Oana Mirea
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  3. Gloria Tamborini
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  4. Manuela Muratori
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  5. Paola Gripari
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  6. Claudia Cefalù
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  7. Sarah Ghulam Ali
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  8. Francesco Maffessanti
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  9. Daniele Andreini
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  10. Gianluca Pontone
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  11. Antonio L. Bartorelli
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  12. Francesco Alamanni
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  13. Marco Agrifoglio
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  14. Mauro Pepi
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Correspondence to Laura Fusini.

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Fusini, L., Mirea, O., Tamborini, G. et al. Incidence and severity of atherosclerotic cardiovascular artery disease in patients undergoing TAVI. Int J Cardiovasc Imaging 31, 975–985 (2015). https://doi.org/10.1007/s10554-015-0651-9

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  • DOI: https://doi.org/10.1007/s10554-015-0651-9

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