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Fusion of optical coherence tomographic and angiographic data for more accurate evaluation of the endothelial shear stress patterns and neointimal distribution after bioresorbable scaffold implantation: comparison with intravascular ultrasound-derived reconstructions

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Abstract

Intravascular ultrasound (IVUS)-based reconstructions have been traditionally used to examine the effect of endothelial shear stress (ESS) on neointimal formation. The aim of this analysis is to compare the association between ESS and neointimal thickness (NT) in models obtained by the fusion of optical coherence tomography (OCT) and coronary angiography and in the reconstructions derived by the integration of IVUS and coronary angiography. We analyzed data from six patients implanted with an Absorb bioresorbable vascular scaffold that had biplane angiography, IVUS and OCT investigation at baseline and 6 or 12 months follow-up. The IVUS and OCT follow-up data were fused separately with the angiographic data to reconstruct the luminal morphology at baseline and follow-up. Blood flow simulation was performed on the baseline reconstructions and the ESS was related to NT. In the OCT-based reconstructions the ESS were lower compared to the IVUS-based models (1.29 ± 0.66 vs. 1.87 ± 0.66 Pa, P = 0.030). An inverse correlation was noted between the logarithmic transformed ESS and the measured NT in all the OCT-based models which was higher than the correlation reported in five of the six IVUS-derived models (−0.52 ± 0.19 Pa vs. −0.10 ± 0.04, P = 0.028). Fusion of OCT and coronary angiography appears superior to IVUS-based reconstructions; therefore it should be the method of choice for the study of the effect of the ESS on neointimal proliferation.

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Acknowledgments

The first author is funded by the Hellenic Cardiological Society, Athens, Greece.

Conflict of interest

Jin Wang is employee of Abbott Vascular. None of the other authors have any conflict of interest to declare.

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Authors and Affiliations

  1. Department of Interventional Cardiology, Thoraxcenter, Erasmus University Medical Centre, ‘s-Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands

    Christos V. Bourantas, Yoshinobu Onuma, Yao-Jun Zhang, Takashi Muramatsu, Roberto Diletti, Hector M. Garcia Garcia & Patrick W. Serruys

  2. Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

    Michail I. Papafaklis

  3. Department of Cardiology, Medical School, University of Ioannina, Ioannina, Greece

    Lampros Lakkas, Katerina K. Naka & Lampros K. Michalis

  4. Department of Materials Science and Engineering, University of Ioannina, Ioannina, Greece

    Antonis Sakellarios, Paschalis Bizopoulos, Fanis Kalatzis & Dimitrios I. Fotiadis

  5. Abbott Vascular, Diegem, Belgium

    Jin Wang

  6. Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan

    Takeshi Kimura

Authors
  1. Christos V. Bourantas
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  2. Michail I. Papafaklis
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  11. Katerina K. Naka
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  12. Dimitrios I. Fotiadis
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  13. Jin Wang
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  15. Takeshi Kimura
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  16. Lampros K. Michalis
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  17. Patrick W. Serruys
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Corresponding author

Correspondence to Patrick W. Serruys.

Additional information

Christos V. Bourantas and Michail I. Papafaklis have contributed equally to this work.

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Bourantas, C.V., Papafaklis, M.I., Lakkas, L. et al. Fusion of optical coherence tomographic and angiographic data for more accurate evaluation of the endothelial shear stress patterns and neointimal distribution after bioresorbable scaffold implantation: comparison with intravascular ultrasound-derived reconstructions. Int J Cardiovasc Imaging 30, 485–494 (2014). https://doi.org/10.1007/s10554-014-0374-3

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