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Reduced global longitudinal and radial strain with normal left ventricular ejection fraction late after effective repair of aortic coarctation: a CMR feature tracking study

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Abstract

We sought to determine whether global and regional left ventricular (LV) strain parameters were altered in repaired coarctation of the aorta (COA) with normal LV ejection fraction (EF) when compared with healthy adult controls, and whether such alterations were related to LV hypertrophy (LVH). We identified 81 patients after COA repair (31 female, age 25 ± 8.5 years) with inclusion criteria at follow-up CMR of: age ≥13 years, time post-repair ≥10 years, no aortic valve disease, LV-EF >50 %). LV deformation indices derived using CMR-feature tracking and volumetric EF were compared between COA patients and normal controls (n = 20, 10 female, age 37 ± 7 years), and between COA with versus without LVH. In repaired COA versus controls, LV-EF (%) was 62 ± 7.2 versus 58 ± 3.0 (p = 0.01), and LV mass (g/m2) 66 ± 16.8 versus 57.7 ± 6.0 (p = 0.0001). LV global longitudinal strain (GLS) was decreased to −17.0 ± 4.7 % in COA (−20 ± 5 % in controls, p = 0.02), and global radial strain (GRS) reduced to 40 ± 15 % (50 ± 12.4 % in controls, p = 0.003). The global circumferential strain (GCS) was preserved in COA at −23 ± 4.7 % (−24.6 ± 2.4 % in controls, p = 0.14). Regionally, LS decrease was marked in the basal segments (septal, p = 0.005, lateral, p = 0.013). In COA with LVH (n = 45, mass 76.3 ± 12.8 g/m2) versus without LVH (n = 36, mass 52.2 ± 10 g/m2), GLS was more markedly decreased (−15.7 ± 4.8 vs. −18.5 ± 4.2 %, p = 0.016, but GRS and GCS were similar (p = 0.49 and 0.27). In post-repair COA with normal LV-EF, GLS and GRS are reduced whilst GCS is preserved. GLS reduction is more pronounced in the presence of LVH. GLS may qualify as indicator of early LV dysfunction.

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Abbreviations

COA:

Coarctation of the aorta

CHD:

Congenital heart disease

CMR-FT:

Cardiac magnetic resonance-feature tracking

LV:

Left ventricle

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Acknowledgments

The authors appreciate the assistance of the Magnetic Resonance Imaging laboratory staff at the Children’s Hospital and Medical Center. We also thank Berthold Klas, BS, TomTec Imaging Systems, TomTec Corporation USA for technical assistance. SK receives support from the American College of Cardiology Foundation and the American Heart Association.

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Authors and Affiliations

  1. Joint Division of Pediatric Cardiology, Children’s Hospital and Medical Center, University of Nebraska College of Medicine/Creighton University School of Medicine, 8200, Dodge Street, Omaha, NE, 68114, USA

    Shelby Kutty, Sheela Rangamani, Jeeva Venkataraman, Ling Li, Scott E. Fletcher & David A. Danford

  2. Division of Imaging Sciences, King’s College London British Heart Foundation Center of Excellence, National Institute of Health Research Biomedical Research Center at Guy’s and St. Thomas’ NHS Foundation Trust, The Rayne Institute, St. Thomas’ Hospital, London, UK

    Andreas Schuster

  3. Department for Radiology and Pediatric Cardiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

    Philipp Beerbaum

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  1. Shelby Kutty
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Correspondence to Shelby Kutty.

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Kutty, S., Rangamani, S., Venkataraman, J. et al. Reduced global longitudinal and radial strain with normal left ventricular ejection fraction late after effective repair of aortic coarctation: a CMR feature tracking study. Int J Cardiovasc Imaging 29, 141–150 (2013). https://doi.org/10.1007/s10554-012-0061-1

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