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Alcohol consumption and serum metabolite concentrations in young women

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Abstract

Purpose

Alcohol consumption is an established breast cancer risk factor, though further research is needed to advance our understanding of the mechanism underlying the association. We used global metabolomics profiling to identify serum metabolites and metabolic pathways that could potentially mediate the alcohol–breast cancer association.

Methods

A cross-sectional analysis of reported alcohol consumption and serum metabolite concentrations was conducted among 211 healthy women 25–29 years old who participated in the Dietary Intervention Study in Children 2006 Follow-Up Study (DISC06). Alcohol–metabolite associations were evaluated using multivariable linear mixed-effects regression.

Results

Alcohol was significantly (FDR p < 0.05) associated with several serum metabolites after adjustment for diet composition and other potential confounders. The amino acid sarcosine, the omega-3 fatty acid eicosapentaenoate, and the steroid 4-androsten-3beta,17beta-diol monosulfate were positively associated with alcohol intake, while the gamma-tocopherol metabolite gamma-carboxyethyl hydroxychroman (CEHC) was inversely associated. Positive associations of alcohol with 2-methylcitrate and 4-androsten-3beta,17beta-diol disulfate were borderline significant (FDR p < 0.10). Metabolite set enrichment analysis identified steroids and the glycine pathway as having more members associated with alcohol consumption than expected by chance.

Conclusions

Most of the metabolites associated with alcohol in the current analysis participate in pathways hypothesized to mediate the alcohol–breast cancer association including hormonal, one-carbon metabolism, and oxidative stress pathways, but they could also affect risk via alternative pathways. Independent replication of alcohol–metabolite associations and prospective evaluation of confirmed associations with breast cancer risk are needed.

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Notes

  1. Children’s Hospital, New Orleans, LA; Johns Hopkins Hospital, Baltimore, MD, Kaiser Permanente Center for Health Research, Portland, OR; University of Medicine and Dentistry of New Jersey, Newark, NJ; Northwestern University Medical School, Chicago, IL; University of Iowa Hospital and Clinics, Iowa City, IA.

  2. Maryland Medical Research Institute, Baltimore, MD.

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Acknowledgments

We thank all DISC06 participants.

Funding

This work was supported by the National Institutes of Health (R01CA104670, P30CA134274) and the Maryland Department of Health’s Cigarette Restitution Fund Program. The sponsors had no role in the study design, analysis, collection and interpretation of the data, the preparation of the manuscript, or the decision to submit the manuscript for publication.

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Authors and Affiliations

  1. Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, 21201, USA

    Joanne F. Dorgan, Seungyoun Jung, Min Zhan, Christina A. Stennett & Yuji Zhang

  2. Department of Epidemiology and Biostatistics, University of Maryland School of Public Health, College Park, MD, 20740, USA

    Cher M. Dallal

  3. Department of Biochemistry, University of Maryland School of Medicine, Baltimore, MD, 21201, USA

    Richard L. Eckert

  4. Department of Epidemiology, University of Iowa College of Public Health, Iowa City, IA, 52242, USA

    Linda G. Snetselaar

  5. Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA

    Linda Van Horn

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  1. Joanne F. Dorgan
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Dorgan, J.F., Jung, S., Dallal, C.M. et al. Alcohol consumption and serum metabolite concentrations in young women. Cancer Causes Control 31, 113–126 (2020). https://doi.org/10.1007/s10552-019-01256-1

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