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Different time trends by gender for the incidence of Hodgkin’s lymphoma among young adults in the USA: a birth cohort phenomenon

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Abstract

Objectives

Hodgkin’s lymphoma (HL) is one of the most common cancers among young adults. We investigated the time trends for HL among the 20–44 age group in the USA by gender to identify the potential factors accounting for the incidence trends.

Methods

Using data from the National Cancer Institute’s Surveillance, Epidemiology, and End Results program for 1973–2010, we conducted age–period–cohort modeling to evaluate birth cohort patterns on incidence trends of HL over time.

Results

For all races combined, the age-adjusted incidence patterns were similar to that of whites. The birth cohort patterns for whites and all races were similar, but the patterns differed according to gender. Specifically, except for the 1970–1975 birth cohort, all other birth cohorts showed an increasing birth cohort trend for females. Conversely, there was a decreasing cohort trend in males beginning in the 1960 birth cohort regardless of the assumptions of the period effect.

Conclusion

The established risk factors for HL can seemingly not explain the gender disparities of the cohort pattern, which necessitates further analytical epidemiological studies to explore the risk factors for this disease with respect to potential differences by gender and by histological subtype.

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Acknowledgments

This work was partly supported by Fogarty training Grants D43TW 008323 and D43TW 007864-01 from the National Institutes of Health.

Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

  1. West China School of Public Health, Sichuan University, Chengdu, 610041, China

    Cairong Zhu

  2. Department of Environmental Health Sciences, Yale School of Public Health, Yale University, 60 College Street, LEPH 442, New Haven, CT, 06520-8034, USA

    Cairong Zhu, Bryan A. Bassig, Kunchong Shi, Huan Guo & Tongzhang Zheng

  3. International Prevention Research Institute, Lyon, France

    Peter Boyle

  4. School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China

    Huan Guo

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  1. Cairong Zhu
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  2. Bryan A. Bassig
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Correspondence to Tongzhang Zheng.

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Zhu, C., Bassig, B.A., Shi, K. et al. Different time trends by gender for the incidence of Hodgkin’s lymphoma among young adults in the USA: a birth cohort phenomenon. Cancer Causes Control 25, 923–931 (2014). https://doi.org/10.1007/s10552-014-0391-5

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  • DOI: https://doi.org/10.1007/s10552-014-0391-5

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