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Time trends in pharyngeal cancer incidence in Norway 1981–2005: a subsite analysis based on a reabstraction and recoding of registered cases

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Abstract

Objective

Incidence rates of oropharyngeal squamous cell carcinoma (SCC) have been reported to be increasing in several countries in recent decades, contrasting with trends of SCCs diagnosed in neighboring anatomical sites. We investigated whether changes in classification systems and/or coding/registration practices might explain the trends in Norway, focusing on changes in oropharyngeal cancer.

Methods

Trends in cancers of the oropharynx, base of tongue, nasopharynx, hypopharynx were graphically presented for the period 1981–2005, before and after recoding. Age-period-cohort and future prediction models were fitted to oropharyngeal SCC incidence.

Results

A total of 85 (3.7%) of the 2315 pharyngeal cancers required recoding. Rates of oropharyngeal cancer in Norway were consistently two to three times higher in men, with rapid increases in both men (5% per annum) and women (4.2% per annum). Assuming generational effects, male cohorts born 1915–1950 were at increasingly higher risk of the disease. The number of oropharyngeal cancer cases is expected to double in Norway by 2020.

Conclusions

The trends were not considered materially biased by potential artefacts. The increasingly higher proportion of oropharyngeal SCC cancers is more likely explained by other factors, including an increasing high-risk HPV prevalence among recent cohorts. These results will likely have consequences on treatment and health care provision in the near future.

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References

  1. Nasman A, Attner P, Hammarstedt L et al (2009) Incidence of human papillomavirus (HPV) positive tonsillar carcinoma in Stockholm, Sweden: an epidemic of viral-induced carcinoma? Int J Cancer 125:362–366

    Article  PubMed  Google Scholar 

  2. Syrjanen S (2004) HPV infections and tonsillar carcinoma. J Clin Pathol 57:449–455

    Article  CAS  PubMed  Google Scholar 

  3. Hammarstedt L, Dahlstrand H, Lindquist D et al (2007) The incidence of tonsillar cancer in Sweden is increasing. Acta Otolaryngol 127:988–992

    Article  PubMed  Google Scholar 

  4. Robinson KL, Macfarlane GJ (2003) Oropharyngeal cancer incidence and mortality in Scotland: are rates still increasing? Oral Oncol 39:31–36

    Article  PubMed  Google Scholar 

  5. Chaturvedi AK, Engels EA, Anderson WF, Gillison ML (2008) Incidence trends for human papillomavirus-related and -unrelated oral squamous cell carcinomas in the United States. J Clin Oncol 26:612–619

    Article  PubMed  Google Scholar 

  6. Frisch M, Hjalgrim H, Jaeger AB, Biggar RJ (2000) Changing patterns of tonsillar squamous cell carcinoma in the United States. Cancer Causes Control 11:489–495

    Article  CAS  PubMed  Google Scholar 

  7. Sturgis EM, Cinciripini PM (2007) Trends in head and neck cancer incidence in relation to smoking prevalence: an emerging epidemic of human papillomavirus-associated cancers? Cancer 110:1429–1435

    Article  PubMed  Google Scholar 

  8. Braakhuis BJ, Visser O, Leemans CR (2009) Oral and oropharyngeal cancer in The Netherlands between 1989 and 2006: Increasing incidence, but not in young adults. Oral Oncol 45:e85–e89

    Article  PubMed  Google Scholar 

  9. Mork J, Glattre E (1998) Squamous cell carcinomas of the head and neck in Norway, 1953–1992: an epidemiologic study of a low-risk population. Cancer Causes Control 9:37–48

    Article  CAS  PubMed  Google Scholar 

  10. D’Souza G, Kreimer AR, Viscidi R et al (2007) Case-control study of human papillomavirus and oropharyngeal cancer. N Engl J Med 356:1944–1956

    Article  PubMed  Google Scholar 

  11. Gillison ML, Koch WM, Capone RB et al (2000) Evidence for a causal association between human papillomavirus and a subset of head and neck cancers. J Natl Cancer Inst 92:709–720

    Article  CAS  PubMed  Google Scholar 

  12. Herrero R, Castellsague X, Pawlita M et al (2003) Human papillomavirus and oral cancer: the International Agency for Research on Cancer multicenter study. J Natl Cancer Inst 95:1772–1783

    PubMed  Google Scholar 

  13. Mork J, Lie AK, Glattre E et al (2001) Human papillomavirus infection as a risk factor for squamous-cell carcinoma of the head and neck. N Engl J Med 344:1125–1131

    Article  CAS  PubMed  Google Scholar 

  14. Applebaum KM, Furniss CS, Zeka A et al (2007) Lack of association of alcohol and tobacco with HPV16-associated head and neck cancer. J Natl Cancer Inst 99:1801–1810

    Article  PubMed  Google Scholar 

  15. Gillison ML, D’Souza G, Westra W et al (2008) Distinct risk factor profiles for human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck cancers. J Natl Cancer Inst 100:407–420

    Article  PubMed  Google Scholar 

  16. Larsen IK, Smastuen M, Johannesen TB et al (2009) Data quality at the Cancer Registry of Norway: an overview of comparability, completeness, validity and timeliness. Eur J Cancer 45:1218–1231

    Article  PubMed  Google Scholar 

  17. Mork J, Thoresen S, Faye-Lund H, Langmark F, Glattre E (1995) Head, neck cancer in Norway. A study of the quality of the Cancer Registry of Norway’s data on head, neck cancer for the period 1953–1991. APMIS 103:375–382

    Article  CAS  PubMed  Google Scholar 

  18. Doll R, Cook P (1967) Summarizing indices for comparison of cancer incidence data. Int J Cancer 2:269–279

    Article  CAS  PubMed  Google Scholar 

  19. Segi M, Kurihara M (1960) Cancer mortality for selected sites in 24 countries (1950–1957). Tohoku University of Medicine, Sendai, p 1

    Google Scholar 

  20. Holford TR (1983) The estimation of age, period and cohort effects for vital rates. Biometrics 39:311–324

    Article  CAS  PubMed  Google Scholar 

  21. Clayton D, Schifflers E (1987) Models for temporal variation in cancer rates. I: Age-period and age-cohort models. Stat Med 6:449–467

    Article  CAS  PubMed  Google Scholar 

  22. Holford TR (1998) Age-period-cohort analysis. Encyclopedia of biostatistics. Wiley, Chichester, pp 82–99

    Google Scholar 

  23. Clayton D, Schifflers E (1987) Models for temporal variation in cancer rates. II: age-period-cohort models. Stat Med 6:469–481

    Article  CAS  PubMed  Google Scholar 

  24. Moller B, Fekjær H, Hakulinen T et al (2003) Prediction of cancer incidence in the Nordic countries: empirical comparison of different approaches. Stat Med 22:2751–2766

    Article  PubMed  Google Scholar 

  25. StataCorp (2009) Stata statistical software. StataCorp LP, College Station

    Google Scholar 

  26. R Development Core Team (2008) R: a language and environment for statistical computing. R Foundation for Statistical Computing, Vienna

    Google Scholar 

  27. Cook MB, Dawsey SM, Freedman ND et al (2009) Sex disparities in cancer incidence by period and age. Cancer Epidemiol Biomarkers Prev 18:1174–1182

    Article  PubMed  Google Scholar 

  28. Bray FI, Weiderpass E (2010) Lung cancer mortality trends in 36 European countries: secular trends and birth cohort patterns by sex and region 1970–2007. Int J Cancer 126:1454–1466

    CAS  PubMed  Google Scholar 

  29. Bray F, Loos AH, McCarron P et al (2005) Trends in cervical squamous cell carcinoma incidence in 13 European countries: changing risk and the effects of screening. Cancer Epidemiol Biomarkers Prev 14:677–686

    Article  PubMed  Google Scholar 

  30. Phillips J, Hilger A (2009) Surgery: are we performing enough tonsillectomies? Nat Rev Clin Oncol 6:439–440

    Article  PubMed  Google Scholar 

  31. Fakhry C, Gillison ML (2006) Clinical implications of human papillomavirus in head and neck cancers. J Clin Oncol 24:2606–2611

    Article  PubMed  Google Scholar 

  32. Schwartz SM, Daling JR, Doody DR et al (1998) Oral cancer risk in relation to sexual history and evidence of human papillomavirus infection. J Natl Cancer Inst 90:1626–1636

    Article  CAS  PubMed  Google Scholar 

  33. Fakhry C, Westra WH, Li S et al (2008) Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial. J Natl Cancer Inst 100:261–269

    Article  CAS  PubMed  Google Scholar 

  34. Ragin CC, Taioli E (2007) Survival of squamous cell carcinoma of the head and neck in relation to human papillomavirus infection: review and meta-analysis. Int J Cancer 121:1813–1820

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Otorhinolaryngology, Oslo University Hospital Rikshospitalet, NO-0027, Oslo, Norway

    Jon Mork

  2. Department of Clinical and Registry-based Research, Cancer Registry of Norway, Institute of Population-based Cancer Research, Oslo, Norway

    Jon Mork, Bjørn Møller, Tove Dahl & Freddie Bray

  3. Department of Biostatistics, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway

    Freddie Bray

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  1. Jon Mork
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  2. Bjørn Møller
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  3. Tove Dahl
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  4. Freddie Bray
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Correspondence to Jon Mork.

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Mork, J., Møller, B., Dahl, T. et al. Time trends in pharyngeal cancer incidence in Norway 1981–2005: a subsite analysis based on a reabstraction and recoding of registered cases. Cancer Causes Control 21, 1397–1405 (2010). https://doi.org/10.1007/s10552-010-9567-9

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  • DOI: https://doi.org/10.1007/s10552-010-9567-9

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