Abstract
Objective
To evaluate prospectively the association between intakes of fish, marine fatty acids, and bladder cancer risk in two ongoing cohorts, the Health Professionals Follow-up Study and the Nurses’ Health Study.
Methods
During 16 and 18 years of follow-up, 501 and 235 incident cases of bladder cancer were diagnosed among men and women, respectively. Cox proportional hazard models were used to estimate incidence rate ratios (RR) and 95% confidence intervals (CI) between fish intake and bladder cancer risk adjusting for age, total caloric intake, pack-years of cigarette smoking, and current smoking.
Results
We observed no significant overall association between total fish intake and bladder cancer risk, even when we compared ≥1 servings of fish per day to fish intake ≤1–3 servings per month. Among men, a statistically significant lower risk of bladder cancer was observed among men consuming fish or high marine fatty acid, after excluding the first 4 years of follow-up (MV RR = 0.60; 95% CI, 0.38–0.94, for ≥1 total fish servings per day compared to ≤1–3 servings per month).
Conclusions
Overall, these findings suggest that fish intake is not likely to be appreciably associated with the risk of bladder cancer.
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Acknowledgments
The work was supported by the Cancer Research and Prevention Foundation and Grants CA98566, CA55075, and CA87969 from the National Cancer Institute, National Institutes of Health, Department of Health and Human Services. We are indebted to Dr. Walter Willett for his expert help and support in this study.
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Holick, C.N., Giovannucci, E.L., Stampfer, M.J. et al. A prospective study of fish, marine fatty acids, and bladder cancer risk among men and women (United States). Cancer Causes Control 17, 1163–1173 (2006). https://doi.org/10.1007/s10552-006-0059-x
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DOI: https://doi.org/10.1007/s10552-006-0059-x