Skip to main content

Advertisement

SpringerLink
Log in

Lifestyle Factors, Radiation and Gastric Cancer in Atomic-Bomb Survivors (Japan)

  • Published:
Cancer Causes & Control Aims and scope Submit manuscript

Abstract

Objective

To examine the association between the incidence of gastric cancer and lifestyle factors such as cigarette smoking, alcohol drinking, and diet as well as atomic bomb radiation exposure.

Methods

Longitudinal study including 38,576 atomic-bomb survivors in Hiroshima and Nagasaki, Japan, followed-up between 1980 and 1999. Individual radiation dose was estimated according to the Dosimetry System 1986 (DS86). Lifestyle determinants were based on the responses to a mail survey sent at baseline. 1270 incident carcinomas of gastric cancer were identified during the 485,575 person-years of follow-up. Poisson regression was used to estimate incidence rate ratios.

Results

Ionizing radiation exposure, male gender, age, and smoking were significantly associated with an increased risk of stomach cancer. No association was suggested between the frequency of consumption of fruit, vegetables, green tea, and soy products and gastric cancer.

Conclusions

In this Japanese population, although radiation and smoking were strong determinants of stomach cancer, no supportive evidence could be shown for the effect of dietary factors.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Foundation for Promotion of Cancer Research. Cancer Statistics in Japan. 2003

  2. InstitutionalAuthorNameThe Research Group for Population-based Cancer Registration in Japan (2003) ArticleTitleCancer incidence and incidence rates in Japan in 1998: estimates based on data from 12 population-based cancer registries Jpn J Clin Oncol 33 IssueID5 241–245

    Google Scholar 

  3. JR Kelley JM Duggan (2003) ArticleTitleGastric cancer epidemiology and risk factors J Clin Epidemiol 56 IssueID1 1–9 Occurrence Handle10.1016/S0895-4356(02)00534-6 Occurrence Handle12589864

    Article  PubMed  Google Scholar 

  4. A Kamineni MA Williams SM Schwartz LS Cook NS Weiss (1999) ArticleTitleThe incidence of gastric carcinoma in Asian migrants to the United States and their descendants Cancer Causes Control 10 IssueID1 77–83 Occurrence Handle10.1023/A:1008849014992 Occurrence Handle10334646

    Article  PubMed  Google Scholar 

  5. YG Adam G Efron (1989) ArticleTitleTrends and controversies in the management of carcinoma of the stomach Surg Gynecol Obstet 169 IssueID4 371–385 Occurrence Handle2476864

    PubMed  Google Scholar 

  6. InstitutionalAuthorNameJapanese Epidemiological Association on Cancer (1998) Site-specific cancers and lifestyle: Food and nutrients in cancer prevention among Japanese Kyushu University Fukuoka

    Google Scholar 

  7. InstitutionalAuthorNameWorld Cancer Research Fund and American Institute for Cancer Research (1997) Food, nutrition and the prevention of cancer: A global perspective American Institute for Cancer Research Washington

    Google Scholar 

  8. S Kono T Hirohata (1996) ArticleTitleNutrition and stomach cancer Cancer Causes Control 7 IssueID1 41–55 Occurrence Handle10.1007/BF00115637 Occurrence Handle8850434

    Article  PubMed  Google Scholar 

  9. C Sauvaget J Nagano M Hayashi E Spencer Y Shimizu N Allen (2003) ArticleTitleVegetables and fruit intake and cancer mortality in the Hiroshima/Nagasaki Life Span Study Br J Cancer 88 IssueID5 689–694 Occurrence Handle10.1038/sj.bjc.6600775 Occurrence Handle12618875

    Article  PubMed  Google Scholar 

  10. DL Preston Y Shimizu DA Pierce A Suyama K Mabuchi (2003) ArticleTitleStudies of mortality of atomic bomb survivors. Report 13: Solid cancer and noncancer disease mortality: 1950–1997 Radiat Res 160 IssueID4 381–407 Occurrence Handle12968934

    PubMed  Google Scholar 

  11. Radiation Effects Research Foundation. Mail questionnaire survey for epidemiologic data on the Life-Span Study extended sample, 1978. Hiroshima: Radiation Effects Research Foundation; 1978. Research Protocol 14–78

  12. J Nagano S Kono DL Preston et al. (2000) ArticleTitleBladder-cancer incidence in relation to vegetable and fruit consumption: a prospective study of atomic-bomb survivors Int J Cancer 86 IssueID1 132–138 Occurrence Handle10.1002/(SICI)1097-0215(20000401)86:1<132::AID-IJC21>3.0.CO;2-M Occurrence Handle10728607

    Article  PubMed  Google Scholar 

  13. C Sauvaget N Allen M Hayashi E Spencer J Nagano (2002) ArticleTitleValidation of a Food Frequency Questionnaire in the Hiroshima/Nagasaki Life Span Study J Epidemiology 12 394–401

    Google Scholar 

  14. DA Pierce Y Shimizu DL Preston M Vaeth K Mabuchi (1996) ArticleTitleStudies of the mortality of atomic bomb survivors. Report 12, Part I. Cancer: 1950–1990 Radiat Res 146 IssueID1 1–27 Occurrence Handle8677290

    PubMed  Google Scholar 

  15. WC Roesh (1987) Final report on the reassessment of atomic-bomb radiation dosimetry in Hiroshima and Nagasaki Radiation Effects Research Foundation Hiroshima

    Google Scholar 

  16. DA Pierce DO Stram M Vaeth (1990) ArticleTitleAllowing for random errors in radiation dose estimates for the atomic bomb survivor data Radiat Res 123 IssueID3 275–284 Occurrence Handle2217725

    PubMed  Google Scholar 

  17. K Mabuchi M Soda E Ron et al. (1994) ArticleTitleCancer incidence in atomic bomb survivors. Part I: Use of the tumor registries in Hiroshima and Nagasaki for incidence studies Radiat Res 137 IssueID2 Suppl S1–S16 Occurrence Handle8127951

    PubMed  Google Scholar 

  18. DE Thompson K Mabuchi E Ron et al. (1994) ArticleTitleCancer incidence in atomic bomb survivors.Part II:Solid tumors, 1958–1987 Radiat Res 137 IssueID2 Suppl S17–S67 Occurrence Handle8127952

    PubMed  Google Scholar 

  19. DL Preston H Lubin DA Pierce (1993) Epicure user’s guide HiroSoft International Corp Seattle

    Google Scholar 

  20. H Matsuura T Yamamoto I Sekine Y Ochi M Otake (1984) ArticleTitlePathological and epidemiologic study of gastric cancer in atomic bomb survivors, Hiroshima and Nagasaki, 1959–77 J Radiat Res (Tokyo) 25 IssueID1 111–129

    Google Scholar 

  21. E Ron DL Preston K Mabuchi DE Thompson M Soda (1994) ArticleTitleCancer incidence in atomic bomb survivors. Part IV: Comparison of cancer incidence and mortality Radiat Res 137 IssueID2 Suppl S98–112 Occurrence Handle8127954

    PubMed  Google Scholar 

  22. S Akiba (1994) ArticleTitleAnalysis of cancer risk related to longitudinal information on smoking habits Environ Health Perspect 102 IssueIDSuppl 8 15–19

    Google Scholar 

  23. I Kato S Tominaga K Matsumoto (1992) ArticleTitleA prospective study of stomach cancer among a rural Japanese population: a 6-year survey Jpn J Cancer Res 83 IssueID6 568–575 Occurrence Handle1644660

    PubMed  Google Scholar 

  24. RW Kneller JK McLaughlin E Bjelke et al. (1991) ArticleTitleA cohort study of stomach cancer in a high-risk American population Cancer 68 IssueID3 672–678 Occurrence Handle2065291

    PubMed  Google Scholar 

  25. A Nomura JS Grove GN Stemmermann RK Severson (1990) ArticleTitleA prospective study of stomach cancer and its relation to diet, cigarettes, and alcohol consumption Cancer Res 50 IssueID3 627–631 Occurrence Handle2297702

    PubMed  Google Scholar 

  26. S Sasazuki S Sasaki S Tsugane (2002) ArticleTitleCigarette smoking, alcohol consumption and subsequent gastric cancer risk by subsite and histologic type Int J Cancer 101 IssueID6 560–566 Occurrence Handle10.1002/ijc.10649 Occurrence Handle12237898

    Article  PubMed  Google Scholar 

  27. W Ye AM Ekstrom LE Hansson R Bergstrom O Nyren (1999) ArticleTitleTobacco, alcohol and the risk of gastric cancer by sub-site and histologic type Int J Cancer 83 IssueID2 223–229 Occurrence Handle10.1002/(SICI)1097-0215(19991008)83:2<223::AID-IJC13>3.0.CO;2-M Occurrence Handle10471531

    Article  PubMed  Google Scholar 

  28. D Corella M Guillen (2001) ArticleTitleDietary habits and epidemiology of gastric carcinoma Hepatogastroenterology 48 IssueID42 1537–1543 Occurrence Handle11813567

    PubMed  Google Scholar 

  29. I Kato S Tominaga Y Ito et al. (1992) ArticleTitleA prospective study of atrophic gastritis and stomach cancer risk Jpn J Cancer Res 83 IssueID11 1137–1142 Occurrence Handle1483928

    PubMed  Google Scholar 

  30. M Inoue K Tajima K Hirose T Kuroishi CM Gao T Kitoh (1994) ArticleTitleLife-style and subsite of gastric cancer–joint effect of smoking and drinking habits Int J Cancer 56 IssueID4 494–499 Occurrence Handle8112885

    PubMed  Google Scholar 

  31. C Sauvaget F Kasagi CA Waldren (2004) ArticleTitleDietary factors and cancer mortality among atomic-bomb survivors Mutat Res 551 IssueID1–2 145–152 Occurrence Handle15225589

    PubMed  Google Scholar 

  32. AI Neugut M Hayek G Howe (1996) ArticleTitleEpidemiology of gastric cancer Semin Oncol 23 IssueID3 281–291 Occurrence Handle8658212

    PubMed  Google Scholar 

  33. SA Lee D Kang KN Shim JW Choe WS Hong H Choi (2003) ArticleTitleEffect of diet and Helicobacter pylori infection to the risk of early gastric cancer J Epidemiol 13 IssueID3 162–168 Occurrence Handle12749604

    PubMed  Google Scholar 

  34. M Ikeda K Yoshimoto T Yoshimura S Kono H Kato M Kuratsune (1983) ArticleTitleA cohort study on the possible association between broiled fish intake and cancer Gann 74 IssueID5 640–648 Occurrence Handle6642138

    PubMed  Google Scholar 

  35. C Nagata N Takatsuka N Kawakami H Shimizu (2002) ArticleTitleA prospective cohort study of soy product intake and stomach cancer death Br J Cancer 87 IssueID1 31–36 Occurrence Handle10.1038/sj.bjc.6600349 Occurrence Handle12085252

    Article  PubMed  Google Scholar 

  36. S Kono M Ikeda S Tokudome M Kuratsune (1988) ArticleTitleA case-control study of gastric cancer and diet in northern Kyushu, Japan Jpn J Cancer Res 79 IssueID10 1067–1074 Occurrence Handle3143695

    PubMed  Google Scholar 

  37. InstitutionalAuthorNameInternational Agency for Research on Cancer (2003) IARC Handbooks of Cancer Prevention, Fruit and Vegetables IARC Press Lyon, France

    Google Scholar 

  38. F Lagarde (2003) ArticleTitleMethodology issues in epidemiological assessment of health effects of low-dose ionising radiation Radiat Prot Dosimetry 104 IssueID4 297–314 Occurrence Handle14579886

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Epidemiology, Radiation Effects Research Foundation, Hiroshima, Japan

    Catherine Sauvaget, Jun Nagano, Kojiro Koyama & Kazunori Kodama

  2. Department of Statistics, Radiation Effects Research Foundation, Hiroshima, Japan

    Frédéric Lagarde

  3. Institute of Health Science, Kyushu University, Fukuoka, Japan

    Jun Nagano

  4. Department of Epidemiology, Radiation Effects Research Foundation, Nagasaki, Japan

    Midori Soda

Authors
  1. Catherine Sauvaget
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Frédéric Lagarde
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jun Nagano
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Midori Soda
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Kojiro Koyama
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Kazunori Kodama
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Catherine Sauvaget.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sauvaget, C., Lagarde, F., Nagano, J. et al. Lifestyle Factors, Radiation and Gastric Cancer in Atomic-Bomb Survivors (Japan). Cancer Causes Control 16, 773–780 (2005). https://doi.org/10.1007/s10552-005-5385-x

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10552-005-5385-x

Keywords

Search

Navigation