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Prostate Cancer Risk Among Men with Diabetes Mellitus (Spain)

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Abstract

Objective: Observational studies have associated diabetes with a decreased risk of prostate cancer. We aimed to evaluate this association using the General Practitioner Research Database in the UK.

Methods: Population based case–control study nested in a cohort.

Results: We identified 2,183 incident cases of prostate cancer between January 1995 and December 2001. We found that diabetic patients had a decreased risk of prostate cancer (OR = 0.72; 95% CI: 0.59–0.87). This association was observed among treated diabetics (OR = 0.63; 95% CI: 0.50–0.80) but not among untreated diabetics (OR = 1.01; 95% CI: 0.73–1.40). Our results suggest that the observed reduced risk could be restricted to users of insulin or sulphonylureas.

Conclusion: Patients with diabetes have a decreased risk of prostate cancer. The role of antidiabetic treatment in this association warrants further research.

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Authors and Affiliations

  1. Centro Español de Investigación Farmacoepidemiológica (CEIFE), C/Almirante 28 2°, 28004, Madrid, Spain

    A. González-Pérez & L.A. García Rodríguez

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  1. A. González-Pérez
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  2. L.A. García Rodríguez
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Correspondence to A. González-Pérez.

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González-Pérez, A., García Rodríguez, L. Prostate Cancer Risk Among Men with Diabetes Mellitus (Spain). Cancer Causes Control 16, 1055–1058 (2005). https://doi.org/10.1007/s10552-005-4705-5

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  • DOI: https://doi.org/10.1007/s10552-005-4705-5

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