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Cancer and Laterality: A Study of The Five Major Paired Organs (UK)

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Abstract

Objective

The human body displays marked asymmetry: paired organs differ bilaterally exerting effects upon cancer incidence and progression. However the factors involved remain contentious. In this large study involving over a quarter of a million cancer patients, we examine the epidemiological correlates of cancer laterality including incidence, stage at diagnosis and survival in the five major paired organs: the breasts, lungs, kidneys, testes and ovaries.

Methods

Cancer patients were selected from the Thames Cancer Registry database and age-standardised incidence rates (ASRs), stage distribution at diagnosis and survival rates computed, stratifying appropriately.

Results

Cancer incidence differed significantly by laterality at all sites studied (p<0.01) but substantially in the lung (left–right incidence-rate ratio [IRR] 0.87), breast (IRR 1.07), testis (IRR 0.87) and in ovarian cancer (IRR 0.86). Autopsy data showed strongly coincident left–right organ size ratios (0.87 in the lungs and 0.87 in the testes). Patients with left testicular cancer, right lung cancer and left ovarian cancer showed significantly better survival than those with contralateral disease (p<0.05).

Conclusions

In the lungs and testes, asymmetries in cancer incidence closely coincided with asymmetries in organ size. Our results suggest that tissue mass in these organs is an important contributor to asymmetry in cancer incidence.

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References

  1. Weiss HA, Devesa SS, Brinton LA (1996) Laterality of breast cancer in the United States. Cancer Causes Control 7:539–543

    CAS  PubMed  Google Scholar 

  2. Perkins CI, Hotes J, Kohler BA, Howe HL (2004) Association between breast cancer laterality and tumor location, United States, 1994–1998. Cancer Causes Control 15:637–645

    Article  PubMed  Google Scholar 

  3. Garfinkel L, Craig L, Seidman H (1959) An appraisal of left and right breast cancer. J Natl Cancer Inst 23:617–631

    CAS  PubMed  Google Scholar 

  4. Saxen E, Teppo L, Hakulinen T (1977) Epidemiology of lung cancer in Scandinavia. IARC Sci Publ 217–228

  5. Parkash O (1977) Lung cancer A statistical study based on autopsy data from 1928 to 1972. Respiration 34:295–304

    CAS  PubMed  Google Scholar 

  6. Delahunt B, Bethwaite P, Nacey JN (1994) Renal cell carcinoma in New Zealand: a national survival study. Urology 43:300–309

    Article  CAS  PubMed  Google Scholar 

  7. Stone JM, Cruickshank DG, Sandeman TF, Matthews JP (1991) Laterality, maldescent, trauma and other clinical factors in the epidemiology of testis cancer in Victoria, Australia. Br J Cancer 64:132–138

    CAS  PubMed  Google Scholar 

  8. Brenner H, Gefeller O (1996) An alternative approach to monitoring cancer patient survival. Cancer 78:2004–2010

    Article  CAS  PubMed  Google Scholar 

  9. Esteve J, Benhamou E, Raymond L (1994) Statistical methods in cancer research. In: Esteve J, Benhamou E, Raymond L (eds) Descriptive epidemiology. IARC Sci Publ, Lyon pp 1–302

    Google Scholar 

  10. Grandmaison GL, Clairand I, Durigon M (2001) Organ weight in 684 adult autopsies: new tables for a Caucasoid population. Forensic Sci Int 15(119):149–154

    Google Scholar 

  11. Spyropoulos E, Borousas D, Mavrikos S, Dellis A, Bourounis M, Athanasiadis S (2002) Size of external genital organs and somatometric parameters among physically normal men younger than 40 years old. Urology 60:485–489

    Article  PubMed  Google Scholar 

  12. Hsieh CC, Trichopoulos D (1991) Breast size, handedness and breast cancer risk Eur J Cancer 27:131–135

    CAS  PubMed  Google Scholar 

  13. Egan KM, Newcomb PA, Titus-Ernstoff L, et al. (1999) The relation of breast size to breast cancer risk in postmenopausal women (United States). Cancer Causes Control 10:115–118

    Article  CAS  PubMed  Google Scholar 

  14. Collaborative Group on Hormonal Factors in Breast Cancer (2002) Breast cancer and breastfeeding: collaborative reanalysis of individual data from 47 epidemiological studies in 30 countries, including 50302 women with breast cancer and 96973 women without the disease. Lancet 360:187–195

    Google Scholar 

  15. Ramadhani MK, Elias SG, van Noord PA, Grobbee DE, Peeters PH, Uiterwaal CS (2005) Innate left handedness and risk of breast cancer: case-cohort study. BMJ 15:882–883

    Google Scholar 

  16. Bogaert AF (1997) Genital asymmetry in men. Hum Reprod. 12:68–72

    Article  CAS  PubMed  Google Scholar 

  17. Ansell PE, Bennett V, Bull D, Jackson MB, Pike LA, Pike MC (1992) Cryptorchidism: a prospective study of 7500 consecutive male births, 1984–1988. John Radcliffe Hospital Cryptorchidism Study Group. Arch Dis Child 67:892–899

    Google Scholar 

  18. Møller H, Evans H (2003) Epidemiology of gonadal germ cell cancer in males and females. APMIS 111:43–46

    PubMed  Google Scholar 

  19. Saito S (2003) Evaluation of cases where the right kidney is higher than the left kidney. Int J Urol 10:359–363

    Article  PubMed  Google Scholar 

  20. Newcomb PA, Storer BE, Longnecker MP, et al. (1994) Lactation and a reduced risk of premenopausal breast cancer. N Engl J Med 13:81–87

    Google Scholar 

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Authors and Affiliations

  1. Thames Cancer Registry, Division of Cancer Studies, Guy’s, King’s and St. Thomas’ School of Medicine, London, SE1 3QD, UK

    Rahul Roychoudhuri, Venkata Putcha & Henrik Møller

Authors
  1. Rahul Roychoudhuri
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  2. Venkata Putcha
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  3. Henrik Møller
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Correspondence to Rahul Roychoudhuri.

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Roychoudhuri, R., Putcha, V. & Møller, H. Cancer and Laterality: A Study of The Five Major Paired Organs (UK). Cancer Causes Control 17, 655–662 (2006). https://doi.org/10.1007/s10552-005-0615-9

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  • DOI: https://doi.org/10.1007/s10552-005-0615-9

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