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Polymorphisms of the AURKA (STK15/Aurora Kinase) Gene and Breast Cancer Risk (United States)

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Abstract

AURKA is an important protein in the regulation of G2 to M transition during mitosis. Due to this regulatory function, it has been hypothesized to be a potential cancer susceptibility gene. Two non-synonymous polymorphisms (F31I and V57I) have been associated with breast cancer risk in prior studies. We sought to confirm these findings in a large case control study nested within a prospective cohort, the Nurses' Health Study. Post-menopausal women who were homozygous for the 31I and 57V alleles had an increased risk of invasive breast cancer (OR 1.63, 95% CI 1.08–2.45). We also performed a meta-analysis to summarize the findings of this and prior studies of association between the F31I polymorphism and breast cancer risk (Summary OR 1.29, 95% CI 1.08–1.53, p-heterogeneity = 0.29). These results confirm prior findings that AURKA represents a low penetrance breast cancer susceptibility gene.

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Acknowledgements

We would like to thank Patrice Soule and her laboratory for sample preparation, and Dr. Hardeep Ranu and her laboratory for genotyping and data management. We are indebted to the participants in the Nurses' Health Study for their continuing dedication and commitment. Supported by National Institutes of Health research grants CA87969, CA49449 and CA65725. D.G.C. is supported by training grant CA 09001-27 from the National Institutes of Health.

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Authors and Affiliations

  1. Department of Epidemiology, Harvard School of Public Health, 677 Huntington Ave., 02115, Boston, MA, USA

    David G. Cox, Susan E. Hankinson & David J. Hunter

  2. Department of Medicine, Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA

    Susan E. Hankinson & David J. Hunter

  3. Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA, USA

    David G. Cox & David J. Hunter

Authors
  1. David G. Cox
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  2. Susan E. Hankinson
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  3. David J. Hunter
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Correspondence to David G. Cox.

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Cox, D.G., Hankinson, S.E. & Hunter, D.J. Polymorphisms of the AURKA (STK15/Aurora Kinase) Gene and Breast Cancer Risk (United States). Cancer Causes Control 17, 81–83 (2006). https://doi.org/10.1007/s10552-005-0429-9

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  • DOI: https://doi.org/10.1007/s10552-005-0429-9

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