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Subfertility and the risk of testicular germ cell tumors (United States)

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Abstract

Objectives: Previous studies have reported an association between subfertility and the risk of testicular germ cell tumors. We examined fertility, measured by number of children fathered and prior diagnosis of infertility, as a risk factor for testicular cancer, while accounting for the influence of occult cancer and cryptorchidism. Methods: Tumor registry data were used to identify 329 cases of testicular cancer in white men aged 20 to 69 years, diagnosed in western Washington State from 1977 to 1983; 672 cancer-free controls were identified by random-digit dialing. Telephone interviews ascertained reproductive histories and basic demographic information. Logistic regression was used to estimate the relative risk of testicular cancer associated with fertility. Results: Testicular cancer risk was decreased among men who had previously fathered a child (age-adjusted odds ratio (OR) 0.76, 95% confidence interval (CI): 0.54–1.06). Inverse associations were seen for seminomas and non-seminomas, and only slight attenuations in the ORs were observed when men with a history of cryptorchidism were excluded. Prior diagnosis of infertility was associated with an increased risk of testicular cancer (OR 2.40, 95% CI: 1.00–5.77). Conclusions: These results are consistent with an increased risk of testicular cancer among men with reduced fertility that goes beyond the effects of cryptorchidism.

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References

  1. InstitutionalAuthorNameUnited Kingdom Testicular Cancer Study Group (1994) ArticleTitleAetiology of testicular cancer: association with congenital abnormalities, age at puberty, infertility, and exercise BMJ 308 1393–1399

    Google Scholar 

  2. H Moller NE Skakkebaek (1999) ArticleTitleRisk of testicular cancer in subfertile men: case-control study BMJ 318 559–562 Occurrence Handle10037628

    PubMed  Google Scholar 

  3. R Jacobsen E Bostofte G Engholm et al. (2000) ArticleTitleFertility and offspring sex ratio of men who develop testicular cancer: a record linkage study Hum Reprod 15 1958–1961 Occurrence Handle10.1093/humrep/15.9.1958 Occurrence Handle10966994

    Article  PubMed  Google Scholar 

  4. R Jacobsen E Bostofte G Engholm et al. (2000) ArticleTitleRisk of testicular cancer in men with abnormal semen characteristics: cohort study BMJ 321 789–792 Occurrence Handle10.1136/bmj.321.7264.789 Occurrence Handle11009515

    Article  PubMed  Google Scholar 

  5. L Richiardi O Akre SM Montgomery et al. (2004) ArticleTitleFecundity and twinning rates as measures of fertility before diagnosis of germ-cell testicular cancer J Natl Cancer Inst 96 145–147 Occurrence Handle14734704

    PubMed  Google Scholar 

  6. BP Haughey S Graham J Brasure et al. (1989) ArticleTitleThe epidemiology of testicular cancer in upstate New York Am J Epidemiol 130 25–36 Occurrence Handle2568087

    PubMed  Google Scholar 

  7. AJ Swerdlow SR Huttly PG Smith (1989) ArticleTitleTestis cancer: post-natal hormonal factors, sexual behaviour and fertility Int J Cancer 43 549–553 Occurrence Handle2539327

    PubMed  Google Scholar 

  8. SD Fossa O Kravdal (2000) ArticleTitleFertility in Norwegian testicular cancer patients Br J Cancer 82 737–741 Occurrence Handle10.1054/bjoc.1999.0989 Occurrence Handle10682691

    Article  PubMed  Google Scholar 

  9. F Brucker-Davis G Pointis D Chevallier P Fenichel (2003) ArticleTitleUpdate on cryptorchidism: endocrine, environmental and therapeutic aspects J Endocrinol Invest 26 575–587 Occurrence Handle12952375

    PubMed  Google Scholar 

  10. CH Strader NS Weiss JR Daling MR Karagas B McKnight (1988) ArticleTitleCryptorchidism, orchiopexy, and the risk of testicular cancer Am J Epidemiol 127 1013–1018 Occurrence Handle2895979

    PubMed  Google Scholar 

  11. J Waksberg (1978) ArticleTitleSampling methods for random digit dialing J␣Am Stat Assoc 73 40–46

    Google Scholar 

  12. RH Depue MC Pike BE Henderson (1983) ArticleTitleEstrogen exposure during gestation and risk of testicular cancer J Natl Cancer Inst 71 1151–1155 Occurrence Handle6140323

    PubMed  Google Scholar 

  13. DJ Tollerud WA Blattner MC Fraser et al. (1985) ArticleTitleFamilial testicular cancer and urogenital developmental anomalies Cancer 55 1849–1854 Occurrence Handle2858262

    PubMed  Google Scholar 

  14. BE Henderson B Benton J Jing MC Yu MC Pike (1979) ArticleTitleRisk factors for cancer of the testis in young men Int J Cancer 23 598–602 Occurrence Handle37169

    PubMed  Google Scholar 

  15. AE Czeizel KJ Rothman (2002) ArticleTitleDoes relaxed reproductive selection explain the decline in male reproductive health? A new hypothesis Epidemiology 13 113–114 Occurrence Handle10.1097/00001648-200201000-00020

    Article  Google Scholar 

  16. L Richiardi O Akre M Lambe et al. (2004) ArticleTitleBirth order, sibship size, and risk for germ-cell testicular cancer Epidemiology 15 323–329 Occurrence Handle10.1097/01.ede.0000120043.45185.7e Occurrence Handle15097013

    Article  PubMed  Google Scholar 

  17. LS Wilcox WD Mosher (1993) ArticleTitleUse of infertility services in the United States Obstet Gynecol 82 122–127 Occurrence Handle8515911

    PubMed  Google Scholar 

  18. AJ Swerdlow KH Wood PG Smith (1983) ArticleTitleA case-control study of the aetiology of cryptorchidism J Epidemiol Community Health 37 238–244 Occurrence Handle6137506

    PubMed  Google Scholar 

  19. C Chilvers MC Pike D Forman K Fogelman ME Wadsworth (1984) ArticleTitleApparent doubling of frequency of undescended testis in England and Wales in 1962–81 Lancet 2 330–332 Occurrence Handle10.1016/S0140-6736(84)92697-7 Occurrence Handle6146873

    Article  PubMed  Google Scholar 

  20. H Campbell RG Newcombe JA Weatherall (1973) ArticleTitleEpidemiology of simple hypospadias BMJ 3 52–53

    Google Scholar 

  21. T Bjerkedal LS Bakketeig (1975) ArticleTitleSurveillance of congenital malformations and other conditions of the newborn Int J Epidemiol 4 31–36 Occurrence Handle1116889

    PubMed  Google Scholar 

  22. E Carlsen A Giwercman N Keiding NE Skakkebaek (1992) ArticleTitleEvidence for decreasing quality of semen during past 50 years BMJ 305 609–613 Occurrence Handle1393072

    PubMed  Google Scholar 

  23. SH Swan EP Elkin L Fenster (1997) ArticleTitleHave sperm densities declined? A reanalysis of global trend data Environ Health Perspect 105 1228–1232 Occurrence Handle9370524

    PubMed  Google Scholar 

  24. SH Safe (2000) ArticleTitleEndocrine disruptors and human health – is there a problem? An update Environ Health Perspect 108 487–493 Occurrence Handle10856020

    PubMed  Google Scholar 

  25. RJ Golden KL Noller L Titus-Ernstoff et al. (1998) ArticleTitleEnvironmental endocrine modulators and human health: an assessment of the biological evidence Crit Rev Toxicol 28 109–227 Occurrence Handle9557209

    PubMed  Google Scholar 

  26. MP Coleman J Esteve P Damiecki A Arslan H Renard (1993) ArticleTitleTrends in cancer incidence and mortality IARC Sci Publ 121 1–806 Occurrence Handle8258476

    PubMed  Google Scholar 

  27. D Forman H Moller (1994) ArticleTitleTesticular cancer Cancer Surv 19 IssueID20 323–341 Occurrence Handle7534631

    PubMed  Google Scholar 

  28. HO Adami R Bergstrom M Mohner et al. (1994) ArticleTitleTesticular cancer in nine northern European countries Int J Cancer 59 33–38 Occurrence Handle7927900

    PubMed  Google Scholar 

  29. KA McGlynn SS Devesa AJ Sigurdson et al. (2003) ArticleTitleTrends in the incidence of testicular germ cell tumors in the United States Cancer 97 63–70 Occurrence Handle10.1002/cncr.11054 Occurrence Handle12491506

    Article  PubMed  Google Scholar 

  30. RM Sharpe NE Skakkebaek (1993) ArticleTitleAre oestrogens involved in falling sperm counts and disorders of the male reproductive tract Lancet 341 1392–1395 Occurrence Handle10.1016/0140-6736(93)90953-E Occurrence Handle8098802

    Article  PubMed  Google Scholar 

  31. J Toppari JC Larsen P Christiansen et al. (1996) ArticleTitleMale reproductive health and environmental xenoestrogens Environ Health Perspect 104 IssueIDSuppl 4 741–803 Occurrence Handle8880001

    PubMed  Google Scholar 

  32. A Pettersson M Kaijser L Richiardi et al. (2004) ArticleTitleWomen smoking and testicular cancer: one epidemic causing another Int J Cancer 109 941–944 Occurrence Handle10.1002/ijc.20088 Occurrence Handle15027129

    Article  PubMed  Google Scholar 

  33. JG Berthelsen NE Skakkebaek (1983) ArticleTitleTesticular cancer: abnormal structure and function of the contralateral testis Int J Androl 6 209–211 Occurrence Handle6885180

    PubMed  Google Scholar 

  34. PM Petersen NE Skakkebaek A Giwercman (1998) ArticleTitleGonadal function in men with testicular cancer: biological and clinical aspects APMIS 106 24–34 Occurrence Handle9524559

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Epidemiology, University of Washington, Seattle, WA, USA

    V. Paul. Doria-Rose, Mary Lou Biggs & Noel S. Weiss

  2. Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M4-B402, P.O. Box 19024, Seattle, WA, 98109-1024, USA

    V. Paul. Doria-Rose, Mary Lou Biggs & Noel S. Weiss

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  1. V. Paul. Doria-Rose
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  2. Mary Lou Biggs
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Correspondence to V. Paul. Doria-Rose.

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Doria-Rose, V.P., Lou Biggs, M. & Weiss, N.S. Subfertility and the risk of testicular germ cell tumors (United States). Cancer Causes Control 16, 651–656 (2005). https://doi.org/10.1007/s10552-005-0169-x

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  • DOI: https://doi.org/10.1007/s10552-005-0169-x

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