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Chemotherapy for ipsilateral breast tumor recurrence: a propensity score-matching study

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Abstract

Purpose

We evaluated the benefit of chemotherapy in patients with ipsilateral breast tumor recurrence (IBTR) by comparing the survival outcomes between the chemotherapy and no chemotherapy groups, using propensity score matching (PSM), and analyze the survival outcomes stratified by hormone receptor status of IBTR.

Methods

We retrospectively analyzed patients who developed invasive IBTR after undergoing breast-conserving surgery at our institution between 1990 and 2013. A 1:1 PSM analysis was performed to compare the survival rates between the two study groups; additional analysis stratified by hormone receptor status was performed. The Kaplan–Meier method and Cox proportional hazards model were used to compare the second recurrence-free survival (RFS), distant metastasis-free survival (DMFS), and overall survival (OS) rates between the two groups.

Results

The 217 IBTR patients had a median follow-up of 125.3 months. After PSM, patients without chemotherapy and with chemotherapy (n = 35 in both groups) were included. No significant differences were observed in the 10-year second RFS [50.2% without chemotherapy vs. 39.8% with chemotherapy, hazard ratio (HR) 0.95, 95% confidence interval (CI) 0.50–1.80], DMFS (85.4% vs. 70.3%, HR 1.51, 95% CI 0.66–3.44), and OS (81.6% vs. 68.6%, HR 1.73, 95% CI 0.76–3.90) rates between the two groups. Analyses stratified by hormone receptor status showed similar findings: no significant differences were observed in the second RFS, DMFS, and OS rates between the two groups in both hormone receptor-positive and -negative groups.

Conclusion

Chemotherapy had no impact in the long-term survival outcomes of IBTR patients regardless of the hormone receptor status.

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Acknowledgements

This study was supported by a Grant (Elimination of Cancer Project Fund) from the Asan Cancer Institute of Asan Medical Center, Seoul (2017-1341).

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Authors and Affiliations

  1. Division of Breast Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-Gu, Seoul, 05505, Republic of Korea

    Soo Yeon Baek, Jisun Kim, Il Yong Chung, Beom Seok Ko, Hee Jeong Kim, Jong Won Lee, Byung Ho Son, Sei-Hyun Ahn & Sae Byul Lee

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  1. Soo Yeon Baek
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  2. Jisun Kim
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  3. Il Yong Chung
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Correspondence to Sae Byul Lee.

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The authors declare that they have no conflict of interest.

Ethical approval

This retrospective chart review study involving human participants was in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The Institutional Review Board of Asan Medical Center approved this study.

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Informed consent was waived due to the retrospective nature of the study.

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Baek, S.Y., Kim, J., Chung, I.Y. et al. Chemotherapy for ipsilateral breast tumor recurrence: a propensity score-matching study. Breast Cancer Res Treat 192, 143–152 (2022). https://doi.org/10.1007/s10549-021-06493-0

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  • DOI: https://doi.org/10.1007/s10549-021-06493-0

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