To the Editor,
We read the publication on “Transforming growth factor beta (TGFβ) receptor II (TGFBR2) promoter region polymorphism in Brazilian breast cancer (BC) patients: association with susceptibility, clinicopathological features, and interaction with TGFB1 haplotypes.” with a great interest [1]. Vitiello et al. concluded that G-875A is a protective factor against BC, especially from luminal-A subtype, but may promote anaplasia in established tumors, consistent with TGFβ signaling roles in BC [1]. Indeed, the effect of genetic factor on BC is possible. The identified effect of G-875A might be modified by other genetic and non-genetic factor; therefore, the confounding effect of TGFβ1can be expected. Nevertheless, the isolated effect of G-875A polymorphism might be explainable via molecular change analysis. Based on the quantum molecular calculation technique as presented in the previous reports [2,3,4], the molecular weight change due to G-875A polymorphism is equal to − 16 g/Mol (151.13 g/Mol to 135.13 g/Mol). Similar to the described pathogenesis in other medical disorders [2,3,4], the G-875A variant will result in a less expression of TGFBR2, which further imply a less amount of growth factor to stimulating BC carcinogenesis. This result is concordant with the previous report by Barlow et al. that a higher expression of TGFBR2 is associated with a poorer prognosis of breast tumor [5].
References
Vitiello GAF, Amarante MK, Banin-Hirata BK, Campos CZ, de Oliveira KB, Losi-Guembarovski R, Watanabe MAE (2019) Transforming growth factor beta receptor II (TGFBR2) promoter region polymorphism in Brazilian breast cancer patients: association with susceptibility, clinicopathological features, and interaction with TGFB1 haplotypes. Breast Cancer Res Treat 1:1. https://doi.org/10.1007/s10549-019-05370-1
Joob B, Wiwanitkit V (2018) Interleukin-2-330T/G and interleukin-10-1082A/G genetic polymorphisms and B-cell non-hodgkin lymphoma. Turk J Haematol 35(4):301–302
Yasri S, Wiwanitkit V, Joob B (2017) WWOX rs11644322 polymorphism, gemcitabine, and pancreatic cancer. Indian J Med Paediatr Oncol 38(3):409–410
Srriwijitalai W, Wiwanitkit V (2018) Interleukin-6 -174G/C polymorphism and end-stage renal disease: is there any role? Saudi J Kidney Dis Transpl 29(3):747–748
Barlow J, Yandell D, Weaver D, Casey T, Plaut K (2003) Higher stromal expression of transforming growth factor-beta type II receptors is associated with poorer prognosis breast tumors. Breast Cancer Res Treat 79(2):149–159
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Yasri, S., Wiwanitkit, V. Transforming growth factor beta receptor II (TGFBR2) promoter region polymorphism. Breast Cancer Res Treat 178, 713 (2019). https://doi.org/10.1007/s10549-019-05414-6
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DOI: https://doi.org/10.1007/s10549-019-05414-6