Skip to main content

Advertisement

SpringerLink
Log in

T-cadherin association with clinicopathological features and prognosis in axillary lymph node-positive breast cancer

  • Clinical trial
  • Published:
Breast Cancer Research and Treatment Aims and scope Submit manuscript

Abstract

The purpose of this study was to investigate the correlation of T-cadherin expression with clinicopathological features and prognosis in patients with axillary lymph node-positive breast cancer. Based on the immunohistochemistry results, all 142 patients with operable axillary lymph node-positive breast cancer were divided into the T-cadherin-negative and T-cadherin-positive groups. Clinical data including the association of T-cadherin expression with clinicopathological features and prognosis were analyzed using the Chi square test and Fisher’s exact test using SPSS 13.0 software. The impact of T-cadherin expression on the 5-year disease-free survival (DFS) and the 5-year overall survival (OS) of these patients was measured using the log-rank test. DFS and OS were analyzed using both Kaplan–Meier function and Cox regression analyses. Compared with the T-cadherin-positive group (55.07, 28.99, and 13.4 %, respectively; P = 0.030, P = 0.0132, and P = 0.009), tumor size >2 cm, lymph-vascular invasion, and pathological stage III disease were seen more frequently in the T-cadherin-negative group (72.60, 49.32, and 31.51 %, respectively). Both 5-year DFS and 5-year OS were poorer in the T-cadherin-negative group than in the T-cadherin-positive group (log-rank test = 9.295, P = 0.002; log-rank test = 5.718, P = 0.017). On multivariate analysis, T-cadherin-negative expression remained an independent prognostic factor for DFS (P = 0.002) but not for OS (P = 0.067). Our results suggested that negative T-cadherin expression has a worse prognosis in patients with axillary lymph node-positive breast cancer.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Fan L, Strasser-Weippl K, Li JJ, St Louis J, Finkelstein DM, Yu KD, Chen WQ, Shao ZM, Goss PE (2014) Breast cancer in China. Lancet Oncol 15(7):279–289. doi:10.1016/S1470-2045(13)70567-9

    Article  Google Scholar 

  2. Won HS, Lee KE, Sung SH, Choi MY, Jo JY, Nam EM, Mun YC, Seong CM, Lee SN (2014) Topoisomerase II alpha and microtubule-associated protein- tau as a predictive marker in axillary lymph node positive breast cancer. Tumori 100(1):80–86. doi:10.1700/1430.15820

    CAS  PubMed  Google Scholar 

  3. Munzone E, Bagnardi V, Rotmensz N, Sporchia A, Mazza M, Pruneri G, Intra M, Sciandivasci A, Gentilini O, Luini A, Viale G, Veronesi P, Colleoni M (2014) Prognostic relevance of peritumoral vascular invasion in immunohistochemically defined subtypes of node-positive breast cancer. Breast Cancer Res Treat 146(3):573–582. doi:10.1007/s10549-014-3043-2

    Article  CAS  PubMed  Google Scholar 

  4. Yip CH, Taib NA, Tan GH, Ng KL, Yoong BK, Choo WY (2009) Predictors of axillary lymph node metastases in breast cancer: is there a role for minimal axillary surgery? World J Surg 33(1):54–57. doi:10.1007/s00268-008-9782-7

    Article  CAS  PubMed  Google Scholar 

  5. Sakakibara M, Fujimori T, Miyoshi T, Nagashima T, Fujimoto H, Suzuki HT, Ohki Y, Fushimi K, Yokomizo J, Nakatani Y, Miyazaki M (2012) Aldehyde dehydrogenase 1-positive cells in axillary lymph node metastases after chemotherapy as a prognostic factor in patients with lymph node-positive breast cancer. Cancer 118(16):3899–3910. doi:10.1002/cncr.26725

    Article  CAS  PubMed  Google Scholar 

  6. Elkhodary TR, Ebrahim MA, Hatata EE, Niazy NA (2014) Prognostic value of lymph node ratio in node-positive breast cancer in Egyptian patients. J Egypt Natl Canc Inst 26(1):31–35. doi:10.1016/j.jnci.2013.10.001

    Article  PubMed  Google Scholar 

  7. Andrews JL, Kim AC, Hens JR (2012) The role and function of cadherins in the mammary gland. Breast Cancer Res 14(1):203. doi:10.1186/bcr3065

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  8. Stemmler MP (2008) Cadherins in development and cancer. Mol BioSyst 4(8):835–850. doi:10.1039/B719215K

    Article  CAS  PubMed  Google Scholar 

  9. Gheldof A, Berx G (2013) Cadherins and epithelial-to-mesenchymal transition. Prog Mol Biol Transl Sci 116:317–336. doi:10.1016/B978-0-12-394311-8.00014-5

    Article  CAS  PubMed  Google Scholar 

  10. Guillaume E, Comunale F, Do Khoa N, Planchon D, Bodin S, Gauthier-Rouviere C (2013) Flotillin microdomains stabilize cadherins at cell–cell junctions. J Cell Sci 126(22):5293–5304. doi:10.1016/B978-0-12-394311-8.00014-5

    Article  CAS  PubMed  Google Scholar 

  11. Hebbard LW, Garlatti M, Young LJ, Cardiff RD, Oshima RG, Ranscht B (2008) T- cadherin supports angiogenesis and adiponectin association with the vasculature in a mouse mammary tumor model. Cancer Res 68(5):1407–1416. doi:10.1158/0008-5472.CAN-07-2953

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  12. Philippova M, Pfaff D, Kyriakakis E, Buechner SA, Iezzi G, Spagnoli GC, Schoenenberger AW, Erne P, Resink TJ (2013) T- cadherin loss promotes experimental metastasis of squamous cell carcinoma. Eur J Cancer 49(8):2048–2058. doi:10.1016/j.ejca.2012.12.026

    Article  CAS  PubMed  Google Scholar 

  13. Adachi Y, Takeuchi T, Nagayama T, Ohtsuki Y, Furihata M (2009) Zeb1- mediated T- cadherin repression increases the invasive potential of gallbladder cancer. FEBS Lett 583(2):430–436. doi:10.1016/j.febslet.2008.12.042

    Article  CAS  PubMed  Google Scholar 

  14. Takeuchi T, Liang SB, Ohtsuki Y (2002) Downregulation of expression of a novel cadherin molecule, T- cadherin, in basal cell carcinoma of the skin. Mol Carcinog 35(4):173–179. doi:10.1002/mc.10088

    Article  CAS  PubMed  Google Scholar 

  15. Mukoyama Y, Utani A, Matsui S, Zhou S, Miyachi Y, Matsuyoshi N (2007) T- cadherin enhances cell-matrix adhesiveness by regulating beta1 integrin trafficking in cutaneous squamous carcinoma cells. Genes Cells 12(6):787–796. doi:10.1111/j.1365-2443.2007.01092.x

    CAS  PubMed  Google Scholar 

  16. Kuphal S, Martyn AC, Pedley J, Crowther LM, Bonazzi VF, Parsons PG, Bosserhoff AK, Hayward NK, Boyle GM (2009) H- cadherin expression reduces invasion of malignant melanoma. Pigment Cell Melanoma Res 22(3):296–306. doi:10.1111/j.1755-148X.2009.00568.x

    Article  CAS  PubMed  Google Scholar 

  17. Ellmann L, Joshi MB, Resink TJ, Bosserhoff AK, Kuphal S (2012) BRN2 is a transcriptional repressor of CDH13 (T- cadherin) in melanoma cells. Invest 92(12):1788–1800. doi:10.1038/labinvest.2012.140

    Article  CAS  Google Scholar 

  18. Makarla PB, Saboorian MH, Ashfaq R, Toyooka KO, Toyooka S, Minna JD, Gazdar AF, Schorge JO (2005) Promoter hypermethylation profile of ovarian epithelial neoplasms. Clin Cancer Res 11(15):5365–5369. doi:10.1158/1078-0432.CCR-04-2455

    Article  CAS  PubMed  Google Scholar 

  19. Hibi K, Kodera Y, Ito K, Akiyama S, Nakao A (2004) Methylation pattern of CDH13 gene in digestive tract cancers. Br J Cancer 91(6):1139–1142. doi:10.1038/sj.bjc.6602095

    PubMed Central  CAS  PubMed  Google Scholar 

  20. Tang Y, Dai Y, Huo J (2012) Decreased expression of T- cadherin is associated with gastric cancer prognosis. Hepatogastroenterology 59(116):1294–1298. doi:10.5754/hge12016

    CAS  PubMed  Google Scholar 

  21. Kim DS, Kim MJ, Lee JY, Kim YZ, Kim EJ, Park JY (2007) Aberrant methylation of E-cadherin and H- cadherin genes in nonsmall cell lung cancer and its relation to clinicopathologic features. Cancer 11(12):2785–2792. doi:10.1002/cncr.23113

    Article  Google Scholar 

  22. Takeuchi T, Misaki A, Chen BK, Ohtsuki Y (1999) H- cadherin expression in breast cancer. Histopathology 35(1):87–88

    Article  CAS  PubMed  Google Scholar 

  23. Toyooka KO, Toyooka S, Virmani AK, Sathyanarayana UG, Euhus DM, Gilcrease M, Minna JD, Gazdar AF (2001) Loss of expression and aberrant methylation of the CDH13 (H-cadherin) gene in breast and lung carcinomas. Cancer Res 61(11):4556–4560

    CAS  PubMed  Google Scholar 

  24. Andreeva AV, Kutuzov MA (2010) Cadherin 13 in cancer. Genes Chromosomes Cancer 49(9):775–790. doi:10.1002/gcc.20787

    CAS  PubMed  Google Scholar 

  25. Ciatto C, Bahna F, Zampieri N, VanSteenhouse HC, Katsamba PS, Ahlsen G, Harrison OJ, Brasch J, Jin X, Posy S, Vendome J, Ranscht B, Jessell TM, Honig B, Shapiro L (2010) T- cadherin structures reveal a novel adhesive binding mechanism. Nat Struct Mol Biol 17(3):339–347. doi:10.1038/nsmb.1781

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  26. Lee SW (1996) H- cadherin, a novel cadherin with growth inhibitory functions and diminished expression in human breast cancer. Nat Med 2(7):776–782

    Article  CAS  PubMed  Google Scholar 

  27. Celebiler Cavusoglu A, Kilic Y, Saydam S, Canda T, Başkan Z, Sevinc AI, Sakizli M (2009) Predicting invasive phenotype with CDH1, CDH13, CD44, and TIMP3 gene expression in primary breast cancer. Cancer Sci 100(12):2341–2345. doi:10.1111/j.1349-7006.2009.01333.x

    Article  PubMed  Google Scholar 

  28. Feng W, Orlandi R, Zhao N, Carcangiu ML, Tagliabue E, Xu J, Bast RC Jr, Yu Y (2010) Tumor suppressor genes are frequently methylated in lymph node metastases of breast cancers. BMC Cancer 20(10):378

    Article  Google Scholar 

  29. Wang Y, Yin Q, Yu Q, Zhang J, Liu Z, Wang S, Lv S, Niu Y (2011) A retrospective study of breast cancer subtypes:the risk of relapse and the relations with treatments. Breast Cancer Res Treat 130(2):489–498. doi:10.1007/s10549-011-1709-6

    Article  PubMed  Google Scholar 

  30. Takahashi T, Saegusa S, Sumino H, Nakahashi T, Iwai K, Morimoto S, Nojima T, Kanda T (2005) Adiponectin, T- cadherin and tumour necrosis factor-alpha in damaged cardiomyocytes from autopsy specimens. J Int Med Res 33(2):236–244

    Article  CAS  PubMed  Google Scholar 

  31. Wang M, Kong D, Zhou Y, Wang W (2014) Expression and predictive value of prognosis of T-cadherin in breast cancer. Chin J Oper Proc Gen Surg 8(2):157–160

    Google Scholar 

  32. Qasim BJ, Ali HH, Hussein AG (2013) Immunohistochemical expression of matrix metalloproteinase-7 in human colorectal adenomas using specified automated cellular image analysis system: a clinicopathological study. Saudi J Gastroenterol. 19(1):23–27

    Article  PubMed Central  PubMed  Google Scholar 

  33. Cimino-Mathews A, Hicks JL, Illei PB et al (2012) Androgen receptor expression is usually maintained in initial surgically resected breast cancer metastases but is often lost in end-stage metastases found at autopsy. Hum Pathol 43:1003–1011

    Article  PubMed Central  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

This work was supported by the Science and Technology Development Plan of Jining No.1 People’s Hospital.

Conflict of interest

The authors declare no conflicts of interest.

Author information

Authors and Affiliations

  1. Department of Thyroid and Breast Surgery, Jining No. 1 People’s Hospital, No. 6, Jiankang Road, Jiningy, 272011, Shandong, People’s Republic of China

    De-di Kong, Wei Wang, Ya-ning Chen, Shi-bing Wang & Yan-zhen Zhou

  2. Department of Pharmacy, Jining No. 1 People’s Hospital, No. 6, Jiankang Road, Jiningy, 272011, Shandong, People’s Republic of China

    Jie Yang

  3. Department of Pathology, Jining No. 1 People’s Hospital, No. 6, Jiankang Road, Jiningy, 272011, Shandong, People’s Republic of China

    Liang Li

Authors
  1. De-di Kong
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jie Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Liang Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Wei Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ya-ning Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Shi-bing Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Yan-zhen Zhou
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to De-di Kong.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kong, Dd., Yang, J., Li, L. et al. T-cadherin association with clinicopathological features and prognosis in axillary lymph node-positive breast cancer. Breast Cancer Res Treat 150, 119–126 (2015). https://doi.org/10.1007/s10549-015-3302-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10549-015-3302-x

Keywords

Search

Navigation