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Molecularly targeted therapies for metastatic triple-negative breast cancer

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Abstract

Triple-negative breast cancer (TNBC) refers to a heterogeneous group of tumors that do not express the estrogen/progesterone-receptor (ER/PR), and human epidermal growth factor receptor-2 (HER2). TNBC is an aggressive histological subtype with limited treatment options and very poor prognosis following progression after standard chemotherapy regimens. There have been significant improvements in the outcome of other subtypes of breast cancer, including ER-positive/HER2 overexpressed tumors, attributed to the addition of targeted therapy, including hormonal agents and trastuzumab. However, no specific targeted agents are currently available for the treatment of TNBC. This review aims to collate and describe the most recent data on targeted therapies that have demonstrated efficacy in the management of metastatic TNBC. Targeted agents that have been investigated in the treatment of metastatic TNBC include inhibitors of poly(ADP-ribose) polymerase, angiogenesis, mammalian target of rapamycin, epidermal growth factor receptor, HDAC, Jak2, and Src. Several of these agents have shown considerable promise.

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The manuscript has never been published and is not under consideration for publication elsewhere. Authors have no financial interest to declare.

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Authors and Affiliations

  1. Department of Medical Oncology, Mercy Cancer Center, Ardmore, OK, USA

    Soley Bayraktar

  2. Department of Medicine, Division of Hematology/Medical Oncology, University of Miami and Sylvester Comprehensive Cancer Center, Miami, FL, USA

    Stefan Glück

  3. Sylvester Comprehensive Cancer Center, Leonard L. Miller School of Medicine, University of Miami, 1475 NW 12th Ave St 3300, Miami, FL, 33136, USA

    Stefan Glück

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  1. Soley Bayraktar
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Correspondence to Soley Bayraktar.

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Bayraktar, S., Glück, S. Molecularly targeted therapies for metastatic triple-negative breast cancer. Breast Cancer Res Treat 138, 21–35 (2013). https://doi.org/10.1007/s10549-013-2421-5

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