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Dietary calcium intake, vitamin D levels, and breast cancer risk: a dose–response analysis of observational studies

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Abstract

Results from the recent meta-analysis suggested a favorable effect of dietary calcium and vitamin D levels on breast cancer risk. However, the relationship of dietary calcium and vitamin D levels with breast cancer risk is unclear. Thus, the dose–response relationship was assessed by restricted cubic spline model and multivariate random-effect meta-regression. Results suggested that women might suffer from the lowest risk of breast cancer with dietary calcium intake of about 600 mg/day, dietary vitamin D intake of about 400 IU/day, and serum vitamin D levels of about 30 ng/ml.

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Authors and Affiliations

  1. Kunshan Municipal Center for Disease Control and Prevention, Kunshan, 215300, Jiangsu, People’s Republic of China

    Zhiqiang Hong & Changwei Tian

  2. Hangzhou Center for Disease Control and Prevention, Hangzhou, 310021, Zhejiang, People’s Republic of China

    Xingliang Zhang

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  1. Zhiqiang Hong
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  2. Changwei Tian
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Correspondence to Changwei Tian.

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Hong, Z., Tian, C. & Zhang, X. Dietary calcium intake, vitamin D levels, and breast cancer risk: a dose–response analysis of observational studies. Breast Cancer Res Treat 136, 309–312 (2012). https://doi.org/10.1007/s10549-012-2172-8

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  • DOI: https://doi.org/10.1007/s10549-012-2172-8

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