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The SNP rs895819 in miR-27a is not associated with familial breast cancer risk in Italians

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References

  1. Lovat F, Valeri N, Croce CM (2011) MicroRNAs in the pathogenesis of cancer. Semin Oncol 38:724–733

    Article  PubMed  CAS  Google Scholar 

  2. Le Quesne J, Caldas C (2010) Micro-RNAs and breast cancer. Mol Oncol 4:230–241

    Article  PubMed  Google Scholar 

  3. Ryan BM, Robles AI, Harris CC (2010) Genetic variation in microRNA networks: the implications for cancer research. Nat Rev Cancer 10:389–402

    Article  PubMed  CAS  Google Scholar 

  4. Catucci I, Yang R, Verderio P, Pizzamiglio S, Heesen L, Hemminki K, Sutter C, Wappenschmidt B, Dick M, Arnold N, Bugert P, Niederacher D, Meindl A, Schmutzler RK, Bartram CC, Ficarazzi F, Tizzoni L, Zaffaroni D, Manoukian S, Barile M, Pierotti MA, Radice P, Burwinkel B, Peterlongo P (2010) Evaluation of SNPs in miR-146a, miR196a2 and miR-499 as low-penetrance alleles in German and Italian familial breast cancer cases. Hum Mutat 31:E1052–E1057

    Article  PubMed  Google Scholar 

  5. Tian T, Xu Y, Dai J, Wu J, Shen H, Hu Z (2010) Functional polymorphisms in two pre-microRNAs and cancer risk: a meta-analysis. Int J Mol Epidemiol Genet 1:358–366

    PubMed  CAS  Google Scholar 

  6. Gao LB, Bai P, Pan XM, Jia J, Li LJ, Liang WB, Tang M, Zhang LS, Wei YG, Zhang L (2011) The association between two polymorphisms in pre-miRNAs and breast cancer risk: a meta-analysis. Breast Cancer Res Treat 125:571–574

    Article  PubMed  Google Scholar 

  7. Li W, Duan R, Kooy F, Sherman SL, Zhou W, Jin P (2009) Germline mutation of microRNA-125a is associated with breast cancer. J Med Genet 46:358–360

    Article  PubMed  CAS  Google Scholar 

  8. Peterlongo P, Caleca L, Cattaneo E, Ravagnani F, Bianchi T, Galastri L, Bernard L, Ficarazzi F, Dall’olio V, Marme F, Langheinz A, Sohn C, Burwinkel B, Giles GG, Baglietto L, Severi G, Odefrey FA, Southey MC, Osorio A, Fernández F, Alonso MR, Benítez J, Barile M, Peissel B, Manoukian S, Radice P (2011) The rs12975333 variant in the miR-125a and breast cancer risk in Germany, Italy, Australia and Spain. J Med Genet 48:703–704

    Article  PubMed  CAS  Google Scholar 

  9. Yang R, Schlehe B, Hemminki K, Sutter C, Bugert P, Wappenschmidt B, Volkmann J, Varon R, Weber BH, Niederacher D, Arnold N, Meindl A, Bartram CR, Schmutzler RK, Burwinkel B (2009) A genetic variant in the pre-miR-27a oncogene is associated with a reduced familial breast cancer risk. Breast Cancer Res Treat 121:693–702

    Article  PubMed  Google Scholar 

  10. Manoukian S, Peissel B, Pensotti V, Barile M, Cortesi L, Stacchiotti S, Terenziani M, Barbera F, Pasquini G, Frigerio S et al (2007) Germline mutations of TP53 and BRCA2 genes in breast cancer/sarcoma families. Eur J Cancer 43:601–606

    Article  PubMed  CAS  Google Scholar 

  11. Hosmer DW, Lemeshow S (1989) Applied logistic regression. John Wiley & Sons, New York

    Google Scholar 

  12. Zhang M, Jin M, Yu Y, Zhang S, Wu Y, Liu H, Liu H, Chen B, Li Q, Ma X, Chen K (2011) Associations of miRNA polymorphisms and female physiological characteristics with breast cancer risk in Chinese population. Eur J Cancer Care. doi:10.1111/j.1365-2354.2011.01308.x

    Google Scholar 

  13. Sun Q, Gu H, Zeng Y, Xia Y, Wang Y, Jing Y, Yang L, Wang B (2010) Hsa-mir-27a genetic variant contributes to gastric cancer susceptibility through affecting miR-27a and target gene expression. Cancer Sci 101:2241–2247

    Article  PubMed  CAS  Google Scholar 

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Acknowledgments

We thank all individuals who participated to this study. This study was partially funded by Italian citizens who allocated the 5 × 1,000 share of their tax payment in support of the Fondazione IRCCS Istituto Nazionale Tumori, according to Italian laws (INT-Institutional strategic projects ‘5 × 1,000’).

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Correspondence to Paolo Radice.

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Catucci, I., Verderio, P., Pizzamiglio, S. et al. The SNP rs895819 in miR-27a is not associated with familial breast cancer risk in Italians. Breast Cancer Res Treat 133, 805–807 (2012). https://doi.org/10.1007/s10549-012-2011-y

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  • DOI: https://doi.org/10.1007/s10549-012-2011-y

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