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Breast cancer screening in BRCA1 and BRCA2 mutation carriers after risk reducing salpingo-oophorectomy

  • Epidemiology
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Abstract

Breast cancer screening is offered to BRCA1 and BRCA2 mutation carriers from the age of 25 years because of their increased risk of breast cancer. As ovarian cancer screening is not effective, risk-reducing salpingho-oophorectomy (RRSO) is offered after child bearing age. RRSO before menopause reduces the breast cancer risk as well as breast density. It can be questioned whether after premenopausal RRSO, the intensive breast cancer screening program needs modification. We evaluated the effectiveness of breast cancer screening by clinical breast examination (CBE), mammography, and MRI in a population of 88 BRCA1 and 51 BRCA2 mutation carriers who had RRSO before the age of 52. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated for each screening modality. During 422 women years, 14 breast cancers were diagnosed; 2 prevalent, 10 screen detected and 2 interval breast cancers (12 in BRCA1 and 2 in BRCA2 mutation carriers). Sensitivity, specificity, PPV, and NPV for the combined screening were 85.7%, 97.6%, 30.0%, and 99.8%, respectively. No tumors were found with CBE, MRI had a sensitivity of 60.0% and mammography of 55.6%. Off all the tumors, 60% were node positive. Effectiveness of CBE and mammography was comparable to earlier findings. MRI screening seemed less effective than earlier findings. After RRSO, the breast cancer risk in BRCA1 and BRCA2 mutation carriers is still high enough to justify intensive breast cancer screening with MRI and mammography.

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Authors and Affiliations

  1. Department of Epidemiology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700, Groningen, The Netherlands

    Ingrid E. Fakkert & Geertruida H. de Bock

  2. Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

    Ingrid E. Fakkert, Liesbeth Jansen & Kees Meijer

  3. Department of Radiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

    Theo Kok

  4. Department of Clinical Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

    Jan C. Oosterwijk

  5. Department of Gynaecology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

    Marian J. E. Mourits

Authors
  1. Ingrid E. Fakkert
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  2. Liesbeth Jansen
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  3. Kees Meijer
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  4. Theo Kok
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  5. Jan C. Oosterwijk
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  6. Marian J. E. Mourits
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  7. Geertruida H. de Bock
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Correspondence to Geertruida H. de Bock.

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Fakkert, I.E., Jansen, L., Meijer, K. et al. Breast cancer screening in BRCA1 and BRCA2 mutation carriers after risk reducing salpingo-oophorectomy. Breast Cancer Res Treat 129, 157–164 (2011). https://doi.org/10.1007/s10549-011-1423-4

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  • DOI: https://doi.org/10.1007/s10549-011-1423-4

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