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New concept for immediate breast reconstruction for invasive cancers: feasibility, oncological safety and esthetic outcome of post-neoadjuvant therapy immediate breast reconstruction versus delayed breast reconstruction: a prospective pilot study

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Abstract

Feasibility and oncological safety of post-adjuvant skin-sparing mastectomy (SSM) plus immediate breast reconstruction (IBR) cannot be evaluated by randomized trials. However, comparative study could modify guidelines for the oncosurgical treatment of invasive breast cancer. Our study compared the feasibility, oncological safety and esthetic outcome of SSM plus latissimus dorsi (LD) flap IBR after chemotherapy (CT) and radiotherapy (RT) with the standard management for invasive breast cancer: mastectomy as primary treatment, adjuvant CT and RT, and LD flap delayed breast reconstruction (DBR). Twenty-six selected patients with stages IIA–IIIA breast cancer were offered post-neoadjuvant SSM plus IBR with LD flap plus implant (IBR group). Seventy-eight other patients had primary mastectomy, adjuvant CT and RT, and LD-assisted DBR (DBR group). After 4.1 years (range 1–8) of follow-up, feasibility, oncological safety, and esthetic outcome were compared. Sixteen (61%) early complications were reported for the IBR group versus 44 (56%) for the DBR group (P = 0.645). Early implant loss was 0% in IBR versus 12% in DBR. IBR had 8 (30%) late complications versus 17 (21%) for DBR (P = 0.362). Capsular contracture and reconstruction failure rates were similar. Local recurrence was 7.7% (2/26) in IBR and 6.4% (5/78) in DBR (P = 0.823). Cosmetic evaluation by independent physicians and by the patients themselves was identical in the two groups. Our concept provides a basis for offering more women the opportunity to elect for immediate reconstruction, even in the setting of radiation therapy.

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Authors and Affiliations

  1. Oncology Unit, Department of Obstetrics and Gynecology, Hôpital Arnaud de Villeneuve, 371 rue du Doyen Gaston Giraud, 34295, Montpellier Cedex 5, France

    Pierre Ludovic Giacalone, Gauthier Rathat & Paul Benos

  2. Biostatistics Unit, Clinical Research Center, 75 rue de la Cardonille, 34295, Montpellier Cedex 5, France

    Jean Pierre Daures

  3. Centre Val d’Aurelle, 34000, Montpellier, France

    David Azria

  4. Department of Pathology, Hôpital Lapeyronie, 371 rue du Doyen Gaston Giraud, 34295, Montpellier Cedex 5, France

    Caroline Rouleau

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  1. Pierre Ludovic Giacalone
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  2. Gauthier Rathat
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  3. Jean Pierre Daures
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Correspondence to Pierre Ludovic Giacalone.

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Giacalone, P.L., Rathat, G., Daures, J.P. et al. New concept for immediate breast reconstruction for invasive cancers: feasibility, oncological safety and esthetic outcome of post-neoadjuvant therapy immediate breast reconstruction versus delayed breast reconstruction: a prospective pilot study. Breast Cancer Res Treat 122, 439–451 (2010). https://doi.org/10.1007/s10549-010-0951-7

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