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Quantitative assessment of the effect of FGFR2 gene polymorphism on the risk of breast cancer

  • Epidemiology
  • Published:
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An Erratum to this article was published on 14 May 2010

Abstract

Fibroblast growth factor receptor 2 is a tyrosine kinase receptor that is a member of the family of individually distinct fibroblast growth factor receptors involved in cell proliferation, invasiveness, motility, and angiogenesis. Genome-wide association studies have identified FGFR2 as a breast cancer (BC) susceptibility gene in populations of European and Asian descent. After that, a number of studies reported that the rs2981582, rs1219648, and rs2420946 polymorphism in FGFR2 has been implicated in BC risk. However, studies on the association between these polymorphism and BC remain conflicting. To derive a more precise estimation of the relationship, a meta-analysis of 46,747 cases and 87,342 controls from 16 published case–control studies was performed. Overall, significantly elevated BC risk was associated with rs2981582, rs1219648, and rs2420946 risk allele when all studies were pooled into the meta-analysis. Significant results were also observed in heterozygous and homozygous when compared with wild genotype for these polymorphisms. In the subgroup analysis by ethnicity, source of controls, significantly increased risks were found for these polymorphisms in all genetic model. In conclusion, this meta-analysis suggests that rs2981582, rs1219648, and rs2420946 polymorphisms in FGFR2 are associated with elevated BC risk.

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Abbreviations

BC:

Breast cancer

FGFR2:

Fibroblast growth factor receptor 2

OR:

Odds ratio

CI:

Confidence interval

SNP:

Single nucleotide polymorphism

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Acknowledgments

We thank Dr Timothy R. Rebbeck for the collaboration and for making the data available for the present meta-analysis.

Author information

Authors and Affiliations

  1. Department of Biochemistry, Shanghai Medical College, Fudan University, Shanghai, 200032, People’s Republic of China

    Chenyou Jia

  2. School of Life Sciences, Shandong University of Technology, Zibo, 255049, People’s Republic of China

    Chenyou Jia

  3. Department of Gastroenterology, Zhongshan Hospital, Fudan University, 180 Feng Lin Road, Shanghai, 200032, People’s Republic of China

    Yu Cai, Yushui Ma & Da Fu

Authors
  1. Chenyou Jia
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  2. Yu Cai
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  3. Yushui Ma
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  4. Da Fu
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Corresponding author

Correspondence to Da Fu.

Additional information

Chenyou Jia and Yu Cai contributed equally to this work.

An erratum to this article can be found at http://dx.doi.org/10.1007/s10549-010-0934-8

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Jia, C., Cai, Y., Ma, Y. et al. Quantitative assessment of the effect of FGFR2 gene polymorphism on the risk of breast cancer. Breast Cancer Res Treat 124, 521–528 (2010). https://doi.org/10.1007/s10549-010-0872-5

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  • DOI: https://doi.org/10.1007/s10549-010-0872-5

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