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TGFB1 T29C polymorphism and breast cancer risk: a meta-analysis based on 10,417 cases and 11,455 controls

  • Epidemiology
  • Published:
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Abstract

Breast cancer is the most prevalent cancer worldwide. Many published articles have evaluated the association between the transforming growth factor beta 1 (TGFB1) T29C polymorphism and breast cancer risk. However, the results remain inconclusive. In order to derive a more precise estimation of the association, a meta-analysis was performed in this study. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the association. A total of 12 studies including 10,417 breast cancer cases and 11,455 controls were identified. Overall, no significant associations between the TGFB1 T29C polymorphism and breast cancer risk were found for CC versus TT (OR = 1.00, 95% CI = 0.92–1.09), TC versus TT (OR = 0.98, 95% CI = 0.93–1.05), CC/TC versus TT (OR = 0.99, 95% CI = 0.93–1.05), and CC versus TC/TT (OR = 1.00, 95% CI = 0.93–1.08). In the subgroup analysis by ethnicity, source of controls, and menopausal status, there was still no significant association detected in all genetic models. In conclusion, the present meta-analysis suggests that the TGFB1 T29C polymorphism is not a low-penetrant risk factor for developing breast cancer.

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Acknowledgments

We thank Meilin Wang (Department of Molecular & Genetic Toxicology, Nanjing Medical University) for critical comments and scientific editing. The authors were fully responsible for all content and editorial decisions, and received no financial support or other form of compensation related to the development of the paper.

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Authors and Affiliations

  1. Department of Oncology, The Affiliated Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing, 210006, People’s Republic of China

    Dongying Gu, Luhong Zhuang, Huaying Huang, Ping Cao, Danling Wang & Jinfei Chen

  2. Department of General Surgery, Jiangsu Cancer Hospital, Nanjing Medical University, Nanjing, 210029, People’s Republic of China

    Jinhai Tang

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  1. Dongying Gu
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  2. Luhong Zhuang
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  3. Huaying Huang
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  4. Ping Cao
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  5. Danling Wang
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  6. Jinhai Tang
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  7. Jinfei Chen
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Correspondence to Jinhai Tang or Jinfei Chen.

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Gu, D., Zhuang, L., Huang, H. et al. TGFB1 T29C polymorphism and breast cancer risk: a meta-analysis based on 10,417 cases and 11,455 controls. Breast Cancer Res Treat 123, 857–861 (2010). https://doi.org/10.1007/s10549-010-0766-6

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  • DOI: https://doi.org/10.1007/s10549-010-0766-6

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