References
Wasserstrom WR, Glass JP, Posner JB (1982) Diagnosis and treatment of leptomeningeal metastases from solid tumors: experience with 90 patients. Cancer 49(4):759–772
Fisher R, DeAngelis LM (2010) Leptomeningeal metastasis. In: Harris JR, Lippman ME, Morrow M, Osborne CK (eds) Disease of the breast, 4th edn. Lippincott Williams & Wilkins, Philadelphia, pp 1000–1007
Fuchs IB, Loebbecke M, Buhler H et al (2002) HER2 in brain metastases: issues of concordance, survival, and treatment. J Clin Oncol 20(19):4130–4133
Johnson ML, Nehhozina T, Conlin AK et al (2008) Clinical and pathologic correlates in breast cancer (BC) brain metastasis (BM): tissue microarray (TMA) studies. J Clin Oncol 26(May 20 suppl):abstract 1039
Gancberg D, Di Leo A, Cardoso F et al (2002) Comparison of HER-2 status between primary breast cancer and corresponding distant metastatic sites. Ann Oncol 13(7):1036–1043
MacFarlane R, Speers C, Masoudi H, Chia S (2008) Molecular changes in the primary breast cancer versus the relapsed/metastatic lesion from a large population-based database and tissue microarray series. J Clin Oncol 26(May 20 suppl):Abstract 1000
Liedtke C, Broglio K, Moulder S et al (2009) Prognostic impact of discordance between triple-receptor measurements in primary and recurrent breast cancer. Ann Oncol 20(12):1953–1958
Wu JM, Fackler MJ, Halushka MK et al (2008) Heterogeneity of breast cancer metastases: comparison of therapeutic target expression and promoter methylation between primary tumors and their multifocal metastases. Clin Cancer Res 14(7):1938–1946
Nam BH, Kim SY, Han HS et al (2008) Breast cancer subtypes and survival in patients with brain metastases. Breast Cancer Res 10(1):R20
Bendell JC, Domchek SM, Burstein HJ et al (2003) Central nervous system metastases in women who receive trastuzumab-based therapy for metastatic breast carcinoma. Cancer 97(12):2972–2977
Brufsky AM, Mayer M, Rugo HS et al (2008) RegistHER: patient characteristics and time course of central nervous system metastases in patients with HER2-positive metastatic breast cancer. In: ASCO Breast cancer symposium, 2008, p Abstract 89, Washington, D.C., 2008
Altundag K, Bondy ML, Mirza NQ et al (2007) Clinicopathologic characteristics and prognostic factors in 420 metastatic breast cancer patients with central nervous system metastasis. Cancer 110(12):2640–2647
Lamovec J, Bracko M (1991) Metastatic pattern of infiltrating lobular carcinoma of the breast: an autopsy study. J Surg Oncol 48(1):28–33
Bidard FC, Guilhaume MN, Gauthier H, Cottu PH, Dieras V, Pierga JY (2009) Meningeal carcinomatosis in HER2-overexpressing breast cancers. J Neurooncol 93(2):287–288
Gauthier H, Guilhaume M-N, Bidard FC et al (2009) Meningeal carcinomatosis in patients with breast cancer: clinical features and prognostic factors in 91 patients from a single institution. Cancer Res 69(Suppl):abstract 1090
Lin NU, Claus E, Sohl J, Razzak AR, Arnaout A, Winer EP (2008) Sites of distant recurrence and clinical outcomes in patients with metastatic triple-negative breast cancer: high incidence of central nervous system metastases. Cancer 113(10):2638–2645
Stemmler HJ, Schmitt M, Harbeck N et al (2006) Application of intrathecal trastuzumab (Herceptintrade mark) for treatment of meningeal carcinomatosis in HER2-overexpressing metastatic breast cancer. Oncol Rep 15(5):1373–1377
Stemmler HJ, Mengele K, Schmitt M et al (2008) Intrathecal trastuzumab (Herceptin) and methotrexate for meningeal carcinomatosis in HER2-overexpressing metastatic breast cancer: a case report. Anti-cancer drugs 19(8):832–836
Platini C, Long J, Walter S (2006) Meningeal carcinomatosis from breast cancer treated with intrathecal trastuzumab. Lancet Oncol 7(9):778–780
Siderov J (2006) Care with intrathecal trastuzumab. Lancet Oncol 7(11):888
Tham YL, Hinckley L, Teh BS, Elledge R (2006) Long-term clinical response in leptomeningeal metastases from breast cancer treated with capecitabine monotherapy: a case report. Clin Breast Cancer 7(2):164–166
Shigekawa T, Takeuchi H, Misumi M et al (2009) Successful treatment of leptomeningeal metastases from breast cancer using the combination of trastuzumab and capecitabine: a case report. Breast Cancer 16(1):88–92
Lin NU, Dieras V, Paul D et al (2009) Multicenter phase II study of lapatinib in patients with brain metastases from HER2-positive breast cancer. Clin Cancer Res 15(4):1452–1459
Boccardo F, Kaufman B, Baselga J et al (2008) Evaluation of lapatinib (Lap) plus capecitabine (Cap) in patients with brain metastses (BM) from HER2 + breast cancer (BC) enrolled in the Lapatinib Expanded Access Program (LEAP) and French Authorisation Temporaire d’Utilisation (ATU). J Clin Oncol 26:abstract 1094
Engelman JA, Zejnullahu K, Mitsudomi T et al (2007) MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 316(5827):1039–1043
Ghoussoub RA, Dillon DA, D’Aquila T, Rimm EB, Fearon ER, Rimm DL (1998) Expression of c-met is a strong independent prognostic factor in breast carcinoma. Cancer 82(8):1513–1520
Shattuck DL, Miller JK, Carraway KL III, Sweeney C (2008) Met receptor contributes to trastuzumab resistance of Her2-overexpressing breast cancer cells. Cancer Res 68(5):1471–1477
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The author discloses the following conflicts:
Genentech: research funding for clinical trials (no direct salary support; Consultant <$10 K).
GlaxoSmithKline: research funding for clinical trials (no direct salary support; Consultant <$10 K).
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This is an invited commentary to article doi:10.1007/s10549-009-0627-3.
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Lin, N.U. Concordance of HER2 in primary tumor and leptomeningeal metastases: now what?. Breast Cancer Res Treat 123, 129–131 (2010). https://doi.org/10.1007/s10549-009-0720-7
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DOI: https://doi.org/10.1007/s10549-009-0720-7