Skip to main content

Advertisement

Log in

Test of Hardy–Weinberg equilibrium in breast cancer case-control studies: an issue may influence the conclusions

  • Letter to the Editor
  • Published:
Breast Cancer Research and Treatment Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Justenhoven C, Hamann U, Schubert F, Zapatka M, Pierl CB, Rabstein S, Selinski S, Mueller T, Ickstadt K, Gilbert M, Ko YD, Baisch C, Pesch B, Harth V, Bolt HM, Vollmert C, Illig T, Eils R, Dippon J, Brauch H (2008) Breast cancer: a candidate gene approach across the estrogen metabolic pathway. Breast Cancer Res Treat 108:137–149. doi:10.1007/s10549-007-9586-8

    Article  PubMed  CAS  Google Scholar 

  2. Le Marchand L, Donlon T, Kolonel LN, Henderson BE, Wilkens LR (2005) Estrogen metabolism-related genes and breast cancer risk: the multiethnic cohort study. Cancer Epidemiol Biomark Prev 14:1998–2003. doi:10.1158/1055-9965.EPI-05-0076

    Article  CAS  Google Scholar 

  3. Zaletayev D, Artamonov V, Mikhaylenko D, Lyubchenko L, Nemtsova M (2005) DNA polymorphisms of several genes and predisposition to breast cancer. Breast Cancer Res 7:S21–S22. doi:10.1186/bcr1100

    Article  Google Scholar 

  4. Smith TR, Levine EA, Perrier ND, Miller MS, Freimanis RI, Lohman K, Case LD, Xu JF, Mohrenweiser HW, Hu JJ (2003) DNA-repair genetic polymorphisms and breast cancer risk. Cancer Epidemiol Biomark Prev 12:1200–1204

    CAS  Google Scholar 

  5. Wittke-Thompson JK, Pluzhnikov A, Cox NJ (2005) Rational inferences about departures from Hardy–Weinberg equilibrium. Am J Hum Genet 76:967–986. doi:10.1086/430507

    Article  PubMed  CAS  Google Scholar 

  6. Frank B, Rigas SH, Bermejo JL, Wiestler M, Wagner K, Hemminki K, Reed MW, Sutter C, Wappenschmidt B, Balasubramanian SP, Meindl A, Kiechle M, Bugert P, Schmutzler RK, Bartram CR, Justenhoven C, Ko YD, Bruning T, Brauch H, Hamann U, Pharoah PP, Dunning AM, Pooley KA, Easton DF, Cox A, Burwinkel B (2008) The CASP8-652 6N del promoter polymorphism and breast cancer risk: a multicenter study. Breast Cancer Res Treat 111:139–144. doi:10.1007/s10549-007-9752-z

    Article  PubMed  CAS  Google Scholar 

  7. Cheng CW, Yu JC, Huang CS, Shieh JC, Fu YP, Wang HW, Wu PE, Shen CY (2008) Polymorphism of cytosolic serine hydroxymethyltransferase, estrogen and breast cancer risk among Chinese women in Taiwan. Breast Cancer Res Treat 111:145–155. doi:10.1007/s10549-007-9754-x

    Article  PubMed  CAS  Google Scholar 

  8. Justenhoven C, Pierl CB, Haas S, Fischer HP, Baisch C, Hamann U, Harth V, Pesch B, Bruning T, Vollmert C, Illig T, Dippon J, Ko YD, Brauch H (2008) The CYP1B1_1358_GG genotype is associated with estrogen receptor-negative breast cancer. Breast Cancer Res Treat 111:171–177. doi:10.1007/s10549-007-9762-x

    Article  PubMed  CAS  Google Scholar 

  9. Gyorffy B, Kocsis I, Vasarhelyi B (2004) Missed calculations and new conclusions: re-calculation of genotype distribution data published in Journal of Investigative Dermatology, 1998–2003. J Invest Dermatol 122:644–646. doi:10.1111/j.0022-202X.2004.22334.x

    Article  PubMed  Google Scholar 

  10. Deng HW, Chen WM, Recker RR (2001) Population admixture: detection by Hardy–Weinberg test and its quantitative effects on linkage-disequilibrium methods for localizing genes underlying complex traits. Genetics 157:885–897

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Zhi-Ming Shao.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yu, KD., Di, GH., Fan, L. et al. Test of Hardy–Weinberg equilibrium in breast cancer case-control studies: an issue may influence the conclusions. Breast Cancer Res Treat 117, 675–677 (2009). https://doi.org/10.1007/s10549-009-0353-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10549-009-0353-x

Keywords

Navigation