Abstract
Nitric oxide (NO) plays a central role in the physiololgy and pathology of diverse tissues. Different studies provide data suggesting that the endothelial cell nitric oxide synthase (NOS3) expression in peritumoral microvessels might be a prognostic indicator in breast cancer patients. However, the putative contribution of common NOS3 germline variants to breast cancer risk remained unknown. A recent work comprising 269 breast cancer patients and 244 controls suggested that NOS3 Glu298Asp polymorphism is associated to breast cancer risk (OR=1.9). We performed an independent analysis of these results in 440 unrelated patients and 321 controls from Spanish population. Although our study was 90% powered to detect ORs ≥1.55, did not find any significant difference in the Glu298Asp allele distribution between cases and controls (P > 0.42). These putative reasons for this result are discussed.
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Acknowledgements
This study was supported by the Ministerio de Educación y Ciencia (the Spanish Ministry of Education and Sciences) PROFIT 010000-2003-89, 2004-69, and by FIS 04/1731. JLR holds a Torres Quevedo grant programme (PTQ04-1-0006). We are grateful to patients and controls, who voluntarily enrolled this project. We also thank Ana Salinas and Mª Carmen Rivero their technical assistance.
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Royo, J.L., Moreno-Nogueira, J.A., Galán, J.J. et al. Lack of Association Between NOS3 Glu298Asp and Breast Cancer Risk: a Case–ontrol Study. Breast Cancer Res Treat 100, 331–333 (2006). https://doi.org/10.1007/s10549-006-9258-0
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DOI: https://doi.org/10.1007/s10549-006-9258-0