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Genetic determinants of bone mass do not relate with breast cancer risk in US white and African-American women

  • Epidemiology
  • Published:
Breast Cancer Research and Treatment Aims and scope Submit manuscript

Abstract

Introduction

The association between high bone mass and increased breast cancer risk has been established. Identification of polymorphisms and the resultant variant receptors suggests the possibility of differential effects on hormone responsive genes when complexed with the hormones. Both estrogen receptor-α (ER) and vitamin D receptor (VDR) polymorphisms have been associated with bone density. Thus, we examined these polymorphisms for association with increased breast cancer risk among US African-American and white women.

Methods

A case–control study was conducted to measure ER and VDR polymorphisms and radial bone mineral density (BMD) in African-American and white women, and to examine the association between polymorphisms, bone density and breast cancer risk. Genotypes and bone density were obtained from 412 women (220 cases and 192 controls, with equal distribution between the two ethnic groups).

Results

We found no evidence for an association between either the ER or VDR genotypes and breast cancer risk. Also, there was no difference in the risk of breast cancer by genotypes after adjusting for ethnicity. The addition of age, sex and ethnicity-specific BMD (Z-scores) did not significantly change the odds ratio for breast cancer.

Conclusions

Our data suggest that the polymorphisms investigated had no effect on risk of breast cancer in this population. Thus, we found no evidence to support our hypothesis that breast cancer cases and controls would have a different distribution of ER and VDR genotypes. Furthermore, the polymorphisms were not associated with differences in bone mass and its relationship with breast cancer risk.

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Acknowledgements

We would like to thank Dr Samuel Brooks, Professor Emeritus, for his expert guidance throughout this study. This research was supported by DAMD 17-98-1-8354 from the United States Department of Defense. We also acknowledge the Barbara Ann Karmanos Cancer Institute for additional support of this project.

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Authors and Affiliations

  1. Department of Biomedical Engineering, Wayne State University, 2202 Bioengineering Center, 818 W. Hancock, Detroit, MI,, 48201, USA

    Pamela J. VandeVord & Paul H. Wooley

  2. Department of Orthopaedic Surgery, Wayne State University, Detroit, MI,, 48202, USA

    Paul H. Wooley & Bin Wu

  3. Department of Internal Medicine, Wayne State University, Detroit, MI,, 48202, USA

    Linda L. Darga & Dorothy A. Nelson

  4. Karmanos Cancer Institute, Wayne State University, Detroit, MI,, 48202, USA

    Linda L. Darga, Richard K. Severson & Dorothy A. Nelson

  5. Department of Family Medicine, Wayne State University, Detroit, MI, , 48202, USA

    Richard K. Severson

Authors
  1. Pamela J. VandeVord
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  2. Paul H. Wooley
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  3. Linda L. Darga
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  4. Richard K. Severson
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  5. Bin Wu
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  6. Dorothy A. Nelson
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Corresponding author

Correspondence to Pamela J. VandeVord.

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VandeVord, P.J., Wooley, P.H., Darga, L.L. et al. Genetic determinants of bone mass do not relate with breast cancer risk in US white and African-American women. Breast Cancer Res Treat 100, 103–107 (2006). https://doi.org/10.1007/s10549-006-9228-6

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  • DOI: https://doi.org/10.1007/s10549-006-9228-6

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