Summary
We identified 4316 unselected incident cases of early-onset breast cancers (<51 ears of age at diagnosis) in 18 Polish hospitals between 1996 and 2003. We were able to obtain a blood sample for DNA analysis from 3472 of these (80.4%). All cases were tested for the presence of three founder mutations in BRCA1. The proportion of cases with a BRCA1 mutation was 5.7%. The hereditary proportions were higher than this for women with breast cancer diagnosed before age 40 (9%), for women with cancer of medullary or atypical medullary histology (28%), for those with bilateral cancer (29%) or with a family history of breast or ovarian cancer (13%). It is reasonable to offer genetic testing to women with early-onset breast cancer in Poland.
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Acknowledgements
We thank Czajka R, Czeszyńska B, Dębniak B, Bręborowicz G, Kalużewski B, Witek A, Skręt A, Lenczewski A and Woytoń J for the submission of blood samples from newborn controls. The authors thank also Gibaszek R for excellent technical support. This study was founded by the Polish Ministry of Science 04/p05/11.
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Lubiński, J., Górski, B., Huzarski, T. et al. BRCA1-positive breast cancers in young women from Poland. Breast Cancer Res Treat 99, 71–76 (2006). https://doi.org/10.1007/s10549-006-9182-3
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DOI: https://doi.org/10.1007/s10549-006-9182-3